Results 161 to 170 of about 80,986 (261)

Exercise‐induced miR‐126 expression improves vascular health in prediabetes: A randomized controlled trial

Experimental Physiology, EarlyView.
Abstract In this study, we investigated whether a structured aerobic exercise programme could enhance microRNA‐126 (miR‐126) expression and improve subclinical atherosclerosis markers [carotid intima–media thickness (CIMT) and ankle–brachial index (ABI)] in individuals with prediabetes.
Elif Yildirim Ayaz, Sadrettin Pençe, Sibel Kuraş, Emine Şeyma Denli Yalvaç, Banu Mesci, Özden Ezgi Üner, Fatoş Nimet Kaya, Berna Dincer, Ferruh Kemal Işman, Aytekin Oğuz   +9 more
wiley   +1 more source

Calciprotein particle‐induced calcium overload triggers mitochondrial dysfunction in endothelial cells

The Journal of Physiology, EarlyView.
Abstract figure legend Calciprotein particles (CPPs) are small calcium‐ and phosphate‐containing nanoaggregates associated with the development of vascular disease (CVD) in chronic kidney disease (CKD). Previously, we have shown that CPPs induce endothelial cell (EC) dysfunction, possibly contributing to CVD in CKD, but the underlying molecular ...
Lian Feenstra, Laurent Chatre, Benoit Bernay, Julien Pontin, Mirjam F. Mastik, Azuwerus van Buiten, Dalibor Nakládal, Bastiaan S. Star, Jan‐Luuk Hillebrands, Guido Krenning   +9 more
wiley   +1 more source

Senolytics and exercise: Dual modalities for rejuvenating muscle

The Journal of Physiology, EarlyView.
Abstract figure legend The role of senolytics on the heart and skeletal muscle. Senescent cell burden increases with ageing, disuse and disease. The senolytics dasatinib+quercetin (D+Q), navitoclax and fisetin, as well as exercise, eliminate senescent cells, reducing senescent cell burden and their senescence‐associated secretory phenotype (SASP ...
Zeynep Elif Yesilyurt‐Dirican, Ce Qi, Uchenna Okpechi, Maya Strand Ford, Georgina M. Ellison‐Hughes   +4 more
wiley   +1 more source

Energetic microdomains and the vascular control of neuronal and muscle excitability: Toward a unified model

The Journal of Physiology, EarlyView.
Abstract figure legend The capillary–mitochondria–ion channel (CMIC) axis scales structural resources to match functional workload. (Left) In settings of restricted energetic capacity (e.g. cortical neurons), sparse capillary networks and modest mitochondrial pools set a lower energetic ceiling, sufficient to support phasic, low‐workload excitability. (
L. Fernando Santana, Scott Earley
wiley   +1 more source

Electrocardiographic Predictors of Major Adverse Cardiovascular Events in Women With Suspected Ischemia and no Obstructive Coronary Artery Disease: Results of the Women's Ischemia Syndrome Evaluation

Annals of Noninvasive Electrocardiology, Volume 31, Issue 3, May 2026.
A cohort of 481 female participants of the Women's Ischemia Syndrome Evaluation (WISE) Original study clinically phenotyped as having suspect ischemia with no obstructive coronary arteries (INOCA) were evaluated for baseline ECG and clinical predictors of time to incident major adverse cardiac events (MACE).
Jennifer R. Dungan, Yasmeen K. Taha, Qinglin Pei, Michael T. Weaver, Michael J. Tavormina, Steven E. Reis, Eileen M. Handberg, C. Noel Bairey Merz, Carl J. Pepine   +8 more
wiley   +1 more source

Coronary microvascular dysfunction in pregnancy: time to pay closer attention? [PDF]

Front Cardiovasc Med
Beneki E, Pyrpyris N, Sakalidis A, Dri E, Iliakis P, Mprotsis T, Perone F, Papanikolaou A, Aznaouridis K, Dimitriadis K, Tsioufis K, Aggeli C.   +11 more
europepmc   +1 more source

DELP Treatment on Vision and Retinal Microcirculation in Patients With Acute Ischemic Stroke: Report of Five Cases and Literature Review

Therapeutic Apheresis and Dialysis, Volume 30, Issue 2, Page 168-175, April 2026.
ABSTRACT Background The delipid extracorporeal lipoprotein filter from plasma (DELP) treatment can effectively reduce blood lipid, increase blood flow, and improve neurological deficits in patients with acute ischemic stroke (AIS). However, its effect on vision and retinal microcirculation in stroke patients has never been reported.
Ning Li, Ronghua Hong, Hua You, Feiping Xu, Qingjun Zhang, Yiwen Lin, Yuting Su, Danmei Lan, Lingjing Jin, Junhui She   +9 more
wiley   +1 more source

Coronary Microvascular Dysfunction in Cardiomyopathies: Insights on Clinical and Prognostic Roles. [PDF]

Rev Cardiovasc Med
Giacobbe F, Meynet P, Balducci M, Capoccia S, Cimino RA, Morena A, Dalu A, D'Ascenzo F, De Filippo O, Novarese F, Bruno F, Raineri C, Conrotto F, Sakalidis A, Omedé P, Giannino G, Angelini F, Bocchino PP, Dusi V, Porto I, De Ferrari GM.   +20 more
europepmc   +1 more source

A Review of Vagus Nerve Stimulation for Disease: Comprehensive Theory and Evidence for Mechanisms of Action

Comprehensive Physiology, Volume 16, Issue 2, April 2026.
Vagus nerve stimulation (VNS) effects span central and peripheral organ systems through diverse mechanistic pathways. This comprehensive review provides a unified synthesis of these mechanisms across neurological, cardiovascular, immunological, metabolic, and gastrointestinal domains, filling a critical gap and serving as a foundational resource for ...
Yifeng Bu, Alex Liang, Benjamin U. Hoffman, Dawn M. Schiehser, Oliver Case, Alan Simmons, Ruth Klaming, Andres Gottfried‐Blackmore, Ravinder K. Mittal, Christopher Puleo, Hubert Lim, Imanuel Lerman   +11 more
wiley   +1 more source

Insulin resistance and coronary microvascular dysfunction: a complex interplay. [PDF]

Cardiovasc Diabetol
Magistri M, Portolan L, Trevisanello A, Tosi F, Locatelli A, Piana S, Rubinelli M, Molinaroli E, Mantovani A, Ribichini F, Kunadian V, Bonadonna R, Scarsini R.   +12 more
europepmc   +1 more source