Results 11 to 20 of about 1,039,827 (235)

Thymosin Alpha-1 Provides Direct Neuroprotection by Engaging the Orexin Receptor HCRTR1 to Suppress Neuronal Necroptosis. [PDF]

Adv Sci (Weinh)
In this study, we unveil a thymus‐brain endocrine axis wherein Tα1 engages HCRTR1 to inhibit RIPK3‐mediated necroptosis. This study nominates the Tal‐HCRTR1‐RIPK3 axis as a potent and clinically translatable therapeutic target for stroke and neurodegeneration.
Kang X, Wang S, Zhang L, Hu M, Su X, Liu Y, Qin Q, Yi H, Yuan L, Cai W, Wei L, Lu Z.   +11 more
europepmc   +2 more sources

Neuropathology of a patient with Parkinson's disease and biallelic expansion in RFC1. [PDF]

Brain Pathol
This is the first report of neuropathology in biallelic RFC1 expansion‐associated Parkinson’s disease (PD). It shows a synucleinopathy of intraneuronal Lewy bodies consistent with the clinical PD diagnosis while neuropathological CANVAS (Cerebellar Ataxia with Neuropathy and bilateral Vestibular Areflexia) features were absent.
Sipilä J, Rauramaa T, Kytövuori L, Majamaa K.   +3 more
europepmc   +2 more sources

Contextual novelty changes reward representations in the striatum [PDF]

, 2010
Reward representation in ventral striatum is boosted by perceptual novelty, although the mechanism of this effect remains elusive. Animal studies indicate a functional loop (Lisman and Grace, 2005) that includes hippocampus, ventral striatum, and ...
Dolan, R J, Bunzeck, N, Stephan, K., Düzel, E, Dolan, R. ; https://orcid.org/, Düzel, E., Guitart-Masip, M. ; https://orcid.org/, Dolan, R. J., Guitart-Masip, M, Guitart-Masip, M., Stephan, K E, Bunzeck, N., Stephan, K. E.   +12 more
core   +1 more source

Semi-automatic parcellation of the corpus striatum [PDF]

SPIE Proceedings, 2007
The striatum is the input component of the basal ganglia from the cerebral cortex. It includes the caudate, putamen, and nucleus accumbens. Thus, the striatum is an important component in limbic frontal-subcortical circuitry and is believed to be relevant both for reward-guided behaviors and for the expression of psychosis.
Ramsey Al-Hakim, Delphine Nain, James J. Levitt, Martha Shenton, Allen R. Tannenbaum   +4 more
openaire   +2 more sources

Constitution d’un grand corpus d’écrits émergents et novices : principes et méthodes [PDF]

, 2017
Constitution d’un grand corpus d’écrits émergents et novices : principes et méthodes Cette contribution propose une réflexion sur la construction d’un vaste corpus d’écrits qui permet d’approfondir notre compréhension des processus en jeu dans l’accès à ...
Vogüé, Sarah De, Sitri, Frédérique, Perini, Marie, Espinoza, Natacha, Garcia, Brigitte, Watorek, Marzena   +5 more
core   +1 more source

Novel oligodendroglial alpha synuclein viral vector models of multiple system atrophy: studies in rodents and nonhuman primates

Acta Neuropathologica Communications, 2017
Multiple system atrophy (MSA) is a horrible and unrelenting neurodegenerative disorder with an uncertain etiology and pathophysiology. MSA is a unique proteinopathy in which alpha-synuclein (α-syn) accumulates preferentially in oligodendroglia rather ...
Ronald J. Mandel, David J. Marmion, Deniz Kirik, Yaping Chu, Clifford Heindel, Thomas McCown, Steven J. Gray, Jeffrey H. Kordower   +7 more
doaj   +1 more source

Partial Reversal of Striatal Damage by Palmitoylethanolamide Administration Following Perinatal Asphyxia

Frontiers in Neuroscience, 2020
Perinatal asphyxia (PA) is a clinical condition brought by a birth temporary oxygen deprivation associated with long-term damage in the corpus striatum, one of the most compromised brain areas.
Lucas D. Udovin, Tamara Kobiec, Tamara Kobiec, María I. Herrera, María I. Herrera, Nicolás Toro-Urrego, Carlos F. Kusnier, Rodolfo A. Kölliker-Frers, Ana B. Ramos-Hryb, Juan P. Luaces, Matilde Otero-Losada, Francisco Capani, Francisco Capani   +12 more
doaj   +1 more source

Diabetic Striatopathy

Acta Médica Portuguesa, 2021
N/a.
Phronpan Chutpiboonwat, Aurauma Chutinet, Borwonkhun Tontiwutikul, Thiti Snabboon   +3 more
doaj   +1 more source

The Influence of Striatal Astrocyte Dysfunction on Locomotor Activity in Dopamine-depleted Rats

Basic and Clinical Neuroscience, 2021
Introduction: Astrocyte dysfunction is the common pathology failing astrocyte-neuron interaction in neurological diseases, including Parkinson’s Disease (PD).
Dmitry Voronkov, Alla Stavrovskaya, Artyom Olshanskiy, Anastasia Guschina, Rudolf Khudoerkov, Sergey Illarioshkin   +5 more
doaj  

Region-specific astrogliosis: differential vessel formation contributes to different patterns of astrogliosis in the cortex and striatum

Molecular Brain, 2020
Brain injury causes astrocytes to become reactive (astrogliosis). In this study, we compared astrogliosis in acutely injured cortex and striatum of adult FVB/N mice induced by stereotaxic injection of ATP, a component of danger-associated molecular ...
Haijie Yang, Jiawei An, Insup Choi, Kihwang Lee, Sang-Myun Park, Ilo Jou, Eun-Hye Joe   +6 more
doaj   +1 more source