Results 61 to 70 of about 40,043 (170)

Stability effects on results of diffusion tensor imaging analysis by reduction of the number of gradient directions due to motion artifacts: an application to presymptomatic Huntington's disease. [PDF]

, 2011
In diffusion tensor imaging (DTI), an improvement in the signal-to-noise ratio (SNR) of the fractional anisotropy (FA) maps can be obtained when the number of recorded gradient directions (GD) is increased.
Kassubek, J, Kloppel, S, Landwehrmeyer, GB, Ludolph, A, Müller, HP, Süssmuth, SD, Tabrizi, SJ   +6 more
core   +2 more sources

The microbiota–gut–brain axis in Huntington's disease: pathogenic mechanisms and therapeutic targets

The FEBS Journal, Volume 292, Issue 6, Page 1282-1315, March 2025.
Disturbances of the microbiota–gut–brain axis are evident in people with Huntington's disease (HD) and in HD animal models. Here, we provide an overview of how the trillions of microorganisms residing in the gut, their secretory products, and the microbiota–gut–brain axis may contribute to HD pathogenesis.
Millicent N. Ekwudo, Carolina Gubert, Anthony J. Hannan   +2 more
wiley   +1 more source

Time course of oxidative damage in different brain regions following transient cerebral ischemia in gerbils [PDF]

, 2001
The time course of oxidative damage in different brain regions was investigated in the gerbil model of transient cerebral ischemia. Animals were subjected to both common carotid arteries occlusion for 5 min.
Al-Dalain, Saied M., Candelario-Jalil, Eduardo, Leon, Olga S., Martinez, Gregorio, Mhadu, Noel H.   +4 more
core  

Amyloid imaging in aging and dementia: testing the amyloid hypothesis in vivo. [PDF]

, 2009
Amyloid imaging represents a major advance in neuroscience, enabling the detection and quantification of pathologic protein aggregations in the brain. In this review we survey current amyloid imaging techniques, focusing on positron emission tomography ...
Jagust, WJ, Rabinovici, GD
core   +2 more sources

Cognitive and Adaptive Functioning of CTNNB1 Syndrome Patients: A Comparison With Autism Spectrum Disorder and Cerebral Palsy

Journal of Intellectual Disability Research, EarlyView.
ABSTRACT Background The CTNNB1 syndrome is a neurodevelopmental disorder considered an ultra‐rare disease, first discovered in 2012. Given its comorbidity of symptoms with more prevalent diseases, such as ASD or CP, many CTNNB1 syndrome patients had previously received those diagnosis. Therefore, the aim of this study is to establish differences on the
Mercè Pallarès‐Sastre, Imanol Amayra, Rafael Pulido, Caroline E. Nunes‐Xavier, Sonia Bañuelos, Fabio Cavaliere, Maitane García   +6 more
wiley   +1 more source

What I think she thinks about my paralysed body: Social inferences about disability‐related content in anosognosia for hemiplegia

Journal of Neuropsychology, Volume 19, Issue S1, Page 75-96, March 2025.
Abstract The neuropsychological disorder of anosognosia for hemiplegia (AHP) can offer unique insights into the neurocognitive processes of body consciousness and representation. Previous studies have found associations between selective social cognition deficits and anosognosia.
Sahba Besharati, Paul M. Jenkinson, Michael Kopelman, Mark Solms, Cristina Bulgarelli, Valentina Pacella, Valentina Moro, Aikaterini Fotopoulou   +7 more
wiley   +1 more source

Integrated genomics and proteomics define huntingtin CAG length-dependent networks in mice. [PDF]

, 2016
To gain insight into how mutant huntingtin (mHtt) CAG repeat length modifies Huntington's disease (HD) pathogenesis, we profiled mRNA in over 600 brain and peripheral tissue samples from HD knock-in mice with increasing CAG repeat lengths.
A Dobin, A Hodges, A Kuhn, A Pal, A Reiner, A Valencia, Andreas Tebbe, B Zhang, B Zhang, BM Bolstad, C Zuccato, CA Ross, Christoph Schaab, Daniel J Lavery, David Howland, DI Shirasaki, Doxa Chatzopoulou, DV Zaykin, EH Aylward, Eliana Marisa Ramos, ES Deneris, ES Lein, Fuying Gao, G Fishell, GA Smith, Giovanni Coppola, HT Orr, I Al-Ramahi, IS Seong, Ismael Al-Ramahi, J Cox, J Cox, J Labbadia, JA Miller, JC Jacobsen, JE Phillips, Jeffrey P Cantle, Jeffrey S Aaronson, JF Gusella, JF Gusella, Jim Rosinski, JM Dowen, JM Van Raamsdonk, JP Vonsattel, Juan Botas, K Becanovic, K Monahan, K Sharma, Karla El-Zein, LB Menalled, LB Menalled, LB Menalled, LS Kaltenbach, M Biagioli, M Heiman, M MACDONALD, M Mann, M Mielcarek, MA Pouladi, MC Oldham, MI Love, MK Lobo, MT Lin, N Wang, Nan Wang, P Giles, P Grange, P Langfelder, P Langfelder, P Langfelder, P Langfelder, P Langfelder, Peter Langfelder, PF Durrenberger, RC Gentleman, S Anders, S Horvath, S Toyoda, Sandeep Deverasetty, Seung Kwak, Steve Horvath, T Geiger, T Lu, WE Johnson, WV Chen, X Gu, X Gu, X William Yang, XH Lu, Xiao-Hong Lu, Y Benjamini, Y Guo, Y Shen, Y Wang, Yining Zhao   +94 more
core   +1 more source

Local sleep in songbirds: different simultaneous sleep states across the avian pallium

Journal of Sleep Research, Volume 34, Issue 3, June 2025.
Summary Wakefulness and sleep have often been treated as distinct and global brain states. However, an emerging body of evidence on the local regulation of sleep stages challenges this conventional view. Apart from unihemispheric sleep, the current data that support local variations of neural oscillations during sleep are focused on the homeostatic ...
Hamed Yeganegi, Janie M. Ondracek
wiley   +1 more source

Neural pathways underlying the production of pitch and rhythm in aphasia

Annals of the New York Academy of Sciences, EarlyView.
Singing is a universal trait, and prior studies suggest singing ability may be preserved in poststroke aphasia. This study examined neural networks underpinning singing in patients with aphasia using white matter connectometry and singing accuracy assessments. Results showed patients with aphasia had poorer singing accuracy than controls, linked to the
Anni Pitkäniemi, Teppo Särkämö, Sini‐Tuuli Siponkoski, Noelia Martinez‐Molina, Alicia Lucendo‐Noriega, Nella Moisseinen, Sari Laitinen, Essi‐Reetta Särkämö, Martin Hartmann, Petri Toiviainen, Aleksi J. Sihvonen   +10 more
wiley   +1 more source

Finding the Words: How Does the Aging Brain Process Language? A Focused Review of Brain Connectivity and Compensatory Pathways

Topics in Cognitive Science, EarlyView.
Abstract As people age, there is a natural decline in cognitive functioning and brain structure. However, the relationship between brain function and cognition in older adults is neither straightforward nor uniform. Instead, it is complex, influenced by multiple factors, and can vary considerably from one person to another.
Monica Baciu, Elise Roger
wiley   +1 more source