Results 131 to 140 of about 720,485 (294)

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Characterization of Compressible Fluctuations in Solar Wind Streams Dominated by Balanced and Imbalanced Turbulence: Parker Solar Probe, Solar Orbiter, and Wind Observations

The Astrophysical Journal
Characterizing compressible fluctuations in the solar wind is essential for understanding their role in solar wind acceleration and heating, yet their origin and evolution across different turbulence regimes remain poorly understood.
C.A. González, C. Gonzalez, A. Tenerani
doaj   +1 more source

Persistent global power fluctuations near a dynamic transition in electroconvection

, 2003
This is a study of the global fluctuations in power dissipation and light transmission through a liquid crystal just above the onset of electroconvection. The source of the fluctuations is found to be the creation and annihilation of defects.
D.J. Evans, E. Bodenschatz, E. Bodenschatz, E. Villermaux, G. Gallavotti, G. Gallavotti, G. Goren, G.M. Wang, J. Shi, J.T. Gleeson, J.T. Gleeson, James T. Gleeson, John R. Cressman, M. Kaiser, P. Coullet, R. Labbé, S. Ashkenazi, S. Ashkenazi, S. Aumaitre, S. Kai, S. Kai, S. Kai, S. Kai, S. Kai, S. Nasuno, S. Nasuno, S. Rasenat, S. Rasenat, S.T. Bramwell, S.T. Bramwell, S.T. Bramwell, Tibor Tóth-Katona, W.I. Goldburg, Walter I. Goldburg, X.-L. Qiu, X.-L. Qiu, X.-L. Qiu, X.-L. Qiu   +37 more
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Correlations and fluctuations - Introduction

, 2001
A rewiew of the development of formalism to describe correlations and fluctuations in multiparticle production is presented. The milestones of history of this development and some obvious sources of correlations in experimental data are recalled. Some recent subjects concerning the correlations are shortly discussed.
openaire   +2 more sources

Diurnal oscillations of amino acids dynamically associate with microbiota and resistome in the colon of pigs

Animal Microbiome
Background Nutrients are one of the key determinants of gut microbiota variation. However, the intricate associations between the amino acid (AA) profile and the dynamic fluctuations in the gut microbiota and resistome remain incompletely elucidated ...
Hongyu Wang, Yue Li, Jinwei You, Ni Feng, Dongfang Wang, Yong Su, Xiaobo Feng   +6 more
doaj   +1 more source

Mapping dynamical heterogeneity in structural glasses to correlated fluctuations of the time variables

, 2011
Dynamical heterogeneities -- strong fluctuations near the glass transition -- are believed to be crucial to explain much of the glass transition phenomenology.
Azita Parsaeian, Horacio E. Castillo, Karina E. Avila, M. Kardar   +3 more
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Running modulates primate and rodent visual cortex differently

eLife
When mice run, activity in their primary visual cortex (V1) is strongly modulated. This observation has altered conceptions of a brain region assumed to be a passive image processor.
John P Liska, Declan P Rowley, Trevor Thai Kim Nguyen, Jens-Oliver Muthmann, Daniel A Butts, Jacob Yates, Alexander C Huk   +6 more
doaj   +1 more source