Results 31 to 40 of about 446,858 (263)

Brain Organization and Human Diseases

Cells, 2022
The cortex is a highly organized structure that develops from the caudal regions of the segmented neural tube. Its spatial organization sets the stage for future functional arealization.
Tamar Sapir, Dalit Sela-Donenfeld, Maayan Karlinski, Orly Reiner   +3 more
doaj   +1 more source

Vision and Cortical Map Development [PDF]

Neuron, 2007
Functional maps arise in developing visual cortex as response selectivities become organized into columnar patterns of population activity. Recent studies of developing orientation and direction maps indicate that both are sensitive to visual experience, but not to the same degree or duration.
White, Leonard E., Fitzpatrick, David
openaire   +2 more sources

Nrg1 intracellular signaling regulates the development of interhemispheric callosal axons in mice

Life Science Alliance
This study shows that the schizophrenia risk gene NRG1 controls the development of callosal connections and implicates NRG1 signaling in the regulation of GAP43, a key protein for axonal growth. Schizophrenia is associated with altered cortical circuitry.
Ángela Rodríguez-Prieto, Isabel Mateos-White, Mar Aníbal-Martínez, Carmen Navarro-González, Cristina Gil-Sanz, Yaiza Domínguez-Canterla, Ana González-Manteiga, Verónica Del Buey Furió, Guillermina López-Bendito, Pietro Fazzari   +9 more
doaj   +1 more source

miR-128 regulates neuronal migration, outgrowth and intrinsic excitability via the intellectual disability gene Phf6

eLife, 2015
miR-128, a brain-enriched microRNA, has been implicated in the control of neurogenesis and synaptogenesis but its potential roles in intervening processes have not been addressed. We show that post-transcriptional mechanisms restrict miR-128 accumulation
Eleonora Franzoni, Sam A Booker, Srinivas Parthasarathy, Frederick Rehfeld, Sabine Grosser, Swathi Srivatsa, Heiko R Fuchs, Victor Tarabykin, Imre Vida, F Gregory Wulczyn   +9 more
doaj   +1 more source

Long Non-coding RNA T-uc.189 Modulates Neural Progenitor Cell Fate by Regulating Srsf3 During Mouse Cerebral Cortex Development

Frontiers in Neuroscience, 2021
Neurogenesis is a complex process that depends on the delicate regulation of spatial and temporal gene expression. In our previous study, we found that transcribed ultra-conserved regions (T-UCRs), a class of long non-coding RNAs that contain UCRs, are ...
Meng Zhang, Junjie Zhou, Li Jiao, Longjiang Xu, Lin Hou, Bin Yin, Boqin Qiang, Shuaiyao Lu, Pengcheng Shu, Xiaozhong Peng, Xiaozhong Peng   +10 more
doaj   +1 more source

A new framework for nicotinic receptor-targeted therapeutic strategies in psychiatric and neurodegenerative disorders

Frontiers in Cellular Neuroscience
The nicotinic acetylcholine receptors (nAChRs) are key modulators of synaptic transmission and cognitive processing within the central nervous system.
Khalid Oudaha, Frédéric Causeret, Frédéric Causeret, Fani Koukouli, Fani Koukouli   +4 more
doaj   +1 more source

Macroanatomical Landmarks Featuring Junctions of Major Sulci and Fissures and Scalp Landmarks Based on the International 10–10 System for Analyzing Lateral Cortical Development of Infants

Frontiers in Neuroscience, 2017
The topographic relationships between the macroanatomical structure of the lateral cortex, including sulci and fissures, and anatomical landmarks on the external surface of the head are known to be consistent.
Daisuke Tsuzuki, Daisuke Tsuzuki, Daisuke Tsuzuki, Fumitaka Homae, Fumitaka Homae, Gentaro Taga, Hama Watanabe, Mie Matsui, Mie Matsui, Ippeita Dan   +9 more
doaj   +1 more source

Cortical Development: New Concepts [PDF]

Neuron, 2005
Progress in understanding development of the cerebral cortex has made significant leaps in recent years in areas including neurogenesis, fate determination, migration, and differentiation—all finally culminating in the establishment of cortical architecture and circuitry.
Fishell, Gord, Kriegstein, Arnold
openaire   +2 more sources

The function of Mef2c toward the development of excitatory and inhibitory cortical neurons

Frontiers in Cellular Neuroscience
Neurodevelopmental disorders (NDDs) are caused by abnormal brain development, leading to altered brain function and affecting cognition, learning, self-control, memory, and emotion.
Claire Ward, Lucas Sjulson, Lucas Sjulson, Renata Batista-Brito, Renata Batista-Brito, Renata Batista-Brito   +5 more
doaj   +1 more source

The ubiquitylome of developing cortical neurons [PDF]

, 2020
Abstract TRIM9 and TRIM67 are neuronally-enriched E3 ubiquitin. Both genes are required for neuronal morphological responses to the axon guidance cue netrin-1. For example, our previously published work demonstrated that the actin polymerase VASP and the netrin receptor DCC exhibit TRIM9 dependent ubiquitylation that is lost upon netrin
Shalini Menon, Dennis Goldfarb, Emily M. Cousins, M. Ben Major, Stephanie L. Gupton   +4 more
openaire   +2 more sources