Results 11 to 20 of about 446,858 (263)

Development of Cortical Interneurons [PDF]

Neuropsychopharmacology, 2014
Inhibitory local circuit neurons (LCNs), often called interneurons, have vital roles in the development and function of cortical networks. Their inhibitory influences regulate both the excitability of cortical projection neurons on the level of individual cells, and the synchronous activity of projection neuron ensembles that appear to be a neural ...
Jianhua, Chu, Stewart A, Anderson
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Malformations of cortical development and epilepsy [PDF]

Dialogues in Clinical Neuroscience, 2008
Malformations of cortical development (MCDs) are an important cause of epilepsy and an extremely interesting group of disorders from the perspective of brain development and its perturbations. Many new MCDs have been described in recent years as a result of improvements in imaging, genetic testing, and understanding of the effects of mutations on the ...
Leventer RJ, GUERRINI, RENZO, Dobyns W.B.   +2 more
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Malformations of cortical development [PDF]

Annals of Neurology, 2016
Malformations of cortical development (MCDs) compose a diverse range of disorders that are common causes of neurodevelopmental delay and epilepsy. With improved imaging and genetic methodologies, the underlying molecular and pathobiological characteristics of several MCDs have been recently elucidated.
Rahul S, Desikan, A James, Barkovich
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Malformations of Cortical Development [PDF]

The Neurologist, 2008
Malformations of cortical development (MCD) are increasingly recognized as an important cause of epilepsy and developmental delay. MCD encompass a wide spectrum of disorders with various underlying genetic etiologies and clinical manifestations. High resolution imaging has dramatically improved our recognition of MCD.This review will provide a brief ...
Trudy, Pang, Ramin, Atefy, Volney, Sheen
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Malformations of cortical development: Embryology and epilepsy. [PDF]

Epilepsia
Abstract One in seven patients with focal epilepsy has a malformation of cortical development (MCD) as underlying cause. Understanding normal cortical development combined with knowledge of where, when, and what goes wrong in different types of MCD provides insight into the mechanisms of epileptogenesis.
Hoeberigs MC, Tousseyn S, ACE Study Group.   +2 more
europepmc   +3 more sources

SnapShot: Cortical Development

Cell, 2012
This SnapShot summarizes current knowledge of mammalian cortical development, with a particular focus on the molecular controls that orchestrate the stepwise decisions leading from multiple types of undifferentiated forebrain progenitors to fully mature projection neurons with correctly-targeted axons and carefully-elaborated dendritic trees, as well ...
Woodworth, Mollie B., Custo Greig, Luciano, Kriegstein, Arnold R., Macklis, Jeffrey   +3 more
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Aberrant cortical development is driven by impaired cell cycle and translational control in a DDX3X syndrome model

eLife, 2022
Mutations in the RNA helicase, DDX3X, are a leading cause of Intellectual Disability and present as DDX3X syndrome, a neurodevelopmental disorder associated with cortical malformations and autism. Yet, the cellular and molecular mechanisms by which DDX3X
Mariah L Hoye, Lorenzo Calviello, Abigail J Poff, Nna-Emeka Ejimogu, Carly R Newman, Maya D Montgomery, Jianhong Ou, Stephen N Floor, Debra L Silver   +8 more
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Malformations of Cortical Development

Brain Pathology, 2012
AbstractStructural abnormalities of the brain are increasingly recognized in patients that suffer from pharmacoresistant focal epilepsies by applying high‐resolution imaging techniques. In many of these patients, epilepsy surgery results in control of seizures.
Aronica, Eleonora, Becker, Albert J., Spreafico, Roberto   +2 more
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Homeostatic Regulation of Interneuron Apoptosis During Cortical Development

Journal of Experimental Neuroscience, 2018
The mammalian cortex consists of two main neuronal types: the principal excitatory pyramidal neurons (PNs) and the inhibitory interneurons (INs). The interplay between these two neuronal populations – which drive excitation and inhibition (E/I balance ...
Myrto Denaxa, Guilherme Neves, Juan Burrone, Vassilis Pachnis   +3 more
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The development of cortical connections

European Journal of Neuroscience, 2006
AbstractThe cortex receives its major sensory input from the thalamus via thalamocortical axons, and cortical neurons are interconnected in complex networks by corticocortical and callosal axons. Our understanding of the mechanisms generating the circuitry that confers functional properties on cortical neurons and networks, although poor, has been ...
Price, D, Kennedy, H, Dehay, C, Zhou, L, Mercier, M, Jossin, Y, Goffinet, A, Tissir, F, Blakey, D, Molnár, Z   +9 more
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