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Hedgehog Signaling in Cortical Development [PDF]

Cells, 2023
The Hedgehog (Hh) pathway plays a crucial role in embryonic development, acting both as a morphogenic signal that organizes tissue formation and a potent mitogenic signal driving cell proliferation.
Eva Cai, Maximiliano Gonzalez Barba, Xuecai Ge   +2 more
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Mapping Genetic Associations With Functional Brain Area Alterations in Schizophrenia and Implications for Cortical Development [PDF]

Brain and Behavior
Background While prior studies have identified regional reduction in gray matter (GM) volume in schizophrenia, it remains unclear whether these alterations are concentrated in specific brain functional areas and how they relate to genetic factors.
Jun‐Ding Zhu, Chih‐Yun Chung, Shu‐Fei Lin, Shih‐Jen Tsai, Albert C. Yang, Pei‐Shan Hou   +5 more
doaj   +2 more sources

Cell-type-specific dysregulation of gene expression due to Chd8 haploinsufficiency during mouse cortical development [PDF]

Cell Genomics
Summary: Disruptive variants in the chromodomain helicase CHD8 are associated with risk for autism spectrum disorder (ASD). CHD8 haploinsufficiency is hypothesized to contribute to ASD by perturbing neurodevelopmental gene expression.
Kristina M. Yim, Marybeth Baumgartner, Martina Krenzer, María F. Rosales Larios, Guillermina Hill-Terán, Timothy Nottoli, Rebecca A. Muhle, James P. Noonan   +7 more
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Structural and Functional Aspects of the Neurodevelopmental Gene NR2F1: From Animal Models to Human Pathology

Frontiers in Molecular Neuroscience, 2021
The assembly and maturation of the mammalian brain result from an intricate cascade of highly coordinated developmental events, such as cell proliferation, migration, and differentiation.
Chiara Tocco, Michele Bertacchi, Michèle Studer   +2 more
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Cell type-specific changes in Wnt signaling and neuronal differentiation in the developing mouse cortex after prenatal alcohol exposure during neurogenesis

Frontiers in Cell and Developmental Biology, 2022
Fetal Alcohol Spectrum Disorder (FASD) encompasses an array of effects of prenatal alcohol exposure (PAE), including physical abnormalities and cognitive and behavioral deficits.
Danielle Sambo, Chiraag Gohel, Qiaoping Yuan, Gauthaman Sukumar, Camille Alba, Clifton L. Dalgard, David Goldman   +6 more
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Delayed cortical development in mice with a neural specific deletion of β1 integrin

Frontiers in Neuroscience, 2023
The adhesion systems employed by migrating cortical neurons are not well understood. Genetic deletion studies of focal adhesion kinase (FAK) and paxillin in mice suggested that these classical focal adhesion molecules control the morphology and speed of ...
Mamunur Rashid, Mamunur Rashid, Eric C. Olson   +2 more
doaj   +1 more source

BAF (mSWI/SNF) complex regulates mediolateral cortical patterning in the developing forebrain

Frontiers in Cell and Developmental Biology, 2022
Early forebrain patterning entails the correct regional designation of the neuroepithelium, and appropriate specification, generation, and distribution of neural cells during brain development.
Huong Nguyen, Huong Nguyen, Godwin Sokpor, Godwin Sokpor, Godwin Sokpor, Arpan Parichha, Linh Pham, Linh Pham, Nidhi Saikhedkar, Yuanbin Xie, Pauline Antonie Ulmke, Pauline Antonie Ulmke, Joachim Rosenbusch, Mehdi Pirouz, Mehdi Pirouz, Rüdiger Behr, Anastassia Stoykova, Beate Brand-Saberi, Huu Phuc Nguyen, Jochen F. Staiger, Shubha Tole, Tran Tuoc, Tran Tuoc   +22 more
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Visualizing Cortical Development and Evolution: A Toolkit Update

Frontiers in Neuroscience, 2022
Visualizing the process of neural circuit formation during neurogenesis, using genetically modified animals or somatic transgenesis of exogenous plasmids, has become a key to decipher cortical development and evolution.
Takuma Kumamoto, Chiaki Ohtaka-Maruyama
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Modeling Somatic Mutations Associated With Neurodevelopmental Disorders in Human Brain Organoids

Frontiers in Molecular Neuroscience, 2022
Neurodevelopmental disorders (NDDs) are a collection of diseases with early life onset that often present with developmental delay, cognitive deficits, and behavioral conditions.
Bipan K. Deb, Helen S. Bateup, Helen S. Bateup, Helen S. Bateup   +3 more
doaj   +1 more source

The L1 cell adhesion molecule constrains dendritic spine density in pyramidal neurons of the mouse cerebral cortex

Frontiers in Neuroanatomy, 2023
A novel function for the L1 cell adhesion molecule, which binds the actin adaptor protein Ankyrin was identified in constraining dendritic spine density on pyramidal neurons in the mouse neocortex.
Kelsey E. Murphy, Kelsey E. Murphy, Sarah D. Wade, Sarah D. Wade, Justin E. Sperringer, Justin E. Sperringer, Vishwa Mohan, Vishwa Mohan, Bryce W. Duncan, Bryce W. Duncan, Erin Y. Zhang, Erin Y. Zhang, Yubin Pak, Yubin Pak, David Lutz, Melitta Schachner, Patricia F. Maness, Patricia F. Maness   +17 more
doaj   +1 more source