Results 21 to 30 of about 446,858 (263)
Mob2 Insufficiency Disrupts Neuronal Migration in the Developing Cortex
Frontiers in Cellular Neuroscience, 2018 Disorders of neuronal mispositioning during brain development are phenotypically heterogeneous and their genetic causes remain largely unknown. Here, we report biallelic variants in a Hippo signaling factor—MOB2—in a patient with one such disorder ...
Adam C. O’Neill +14 more
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Translational control in cortical development
Frontiers in Neuroanatomy, 2023 Differentiation of specific neuronal types in the nervous system is worked out through a complex series of gene regulation events. Within the mammalian neocortex, the appropriate expression of key transcription factors allocates neurons to different cortical layers according to an inside-out model and endows them with specific properties.
Federico Cremisi, Robert Vignali
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Cortical Development deNUDEd [PDF]
Neuron, 2004 The development of the cerebral cortex is a highly orchestrated process of cell division and migration. In this issue of Neuron, Feng and Walsh and Shu et al. examine the roles of two related proteins, Nde1 (mNudE) and Ndel1 (NUDEL), in cortical development.
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Sleep and Early Cortical Development [PDF]
Current Sleep Medicine Reports, 2015 Sleep is increasingly recognized as a key process in neurodevelopment. Animal data show that sleep is essential for the maturation of fundamental brain functions, and growing epidemiological findings indicate that children with early sleep disturbance suffer from later cognitive, attentional, and psychosocial problems.
Kurth S, Olini N, Huber R, LeBourgeois M
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Frontiers in Cell and Developmental Biology, 2021 Poly (ADP-ribose) polymerase 1 (PARP1) is a ubiquitously expressed enzyme that regulates DNA damage repair, cell death, inflammation, and transcription.
Megan M. Nelson +6 more
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Cells, 2020 Radial neuron migration in the developing cerebral cortex is a complex journey, starting in the germinal zones and ending in the cortical plate. In mice, migratory distances can reach several hundreds of microns, or millimeters in humans.
Brandon L. Meyerink +2 more
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eLife, 2015 NG2 cells, oligodendrocyte progenitors, receive a major synaptic input from interneurons in the developing neocortex. It is presumed that these precursors integrate cortical networks where they act as sensors of neuronal activity.
David Orduz +7 more
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Cell Reports, 2021 Summary: The cerebral cortex executes highly skilled movement, necessitating that it connects accurately with specific brainstem and spinal motor circuitry.
Vibhu Sahni +3 more
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Frontiers in Cellular Neuroscience, 2018 Several factors regulate cortical development, such as changes in local connectivity and the influences of dynamical synapses. In this study, we simulated various factors affecting the regulation of neural network activity during cortical development ...
Radwa Khalil +6 more
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Malformations of cortical development [PDF]
Arquivos de Neuro-Psiquiatria, 2009 Malformations of cortical development (MCD) have been increasingly identified. The purpose of this presentation is to review the current knowledge of the MCD. Before we address this issue, we will briefly present a review of cortical development. The second part of this presentation will address the most important MCD.
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