Results 121 to 130 of about 68,657 (264)

Individual and Sex Differences in Behavior and Cortical Excitability in the Rat Valproate Model of Autism. [PDF]

Cells
Kelemen V, Szeredi-Faragó Z, Puskás J, Borbély S, Bencsik N, Szűcs A, Varró P.   +6 more
europepmc   +1 more source

Theta oscillations, epileptogenesis, and focal seizures in rodent models of mesial temporal lobe epilepsy

Epilepsia, EarlyView.
Abstract Theta oscillations (4–12 Hz) are a prominent network rhythm within hippocampal and parahippocampal structures. Driven by cholinergic and γ‐aminobutyric acidergic inputs originating from the medial septum, physiological theta gates network excitability to control spatial navigation, memory encoding, and sensorimotor integration during specific ...
Maxime Lévesque, Massimo Avoli
wiley   +1 more source

Kv3.1 activation suppresses provoked and spontaneous seizures in a mouse Dravet syndrome model

Epilepsia, EarlyView.
Abstract Objective γ‐Aminobutyric acidergic (GABAergic) parvalbumin‐positive (PV+) interneurons are critical for maintaining cortical inhibitory tone, with their dysfunction predictably leading to epilepsy. Rapid PV+ interneuron firing is essential for their normal function and is maintained in part by potassium voltage‐gated channels.
Sheryl Anne D. Vermudez, Mustafa Q. Hameed, Yongho Choe, Gabrielle E. McGinty, Amanda M. Liebhardt, Rui Lin, Benjamin Hui, Yini Liang, David J. Arce, Henry H. C. Lee, Mustafa Sahin, Alexander Rotenberg   +11 more
wiley   +1 more source

Focused ultrasound ventro-oral thalamotomy alters cortical excitability and motor control in focal hand dystonia. [PDF]

Brain Commun
Maamary J, Peters J, Osborne I, Kyle K, Olsen N, Ruge D, Jonker B, Barnett Y, Tisch S.   +8 more
europepmc   +1 more source

Limited sex‐specific structural alterations across common epilepsies: A worldwide ENIGMA study

Epilepsia, EarlyView.
Abstract Objective Epilepsy is characterized by widespread cortical and subcortical structural alterations beyond the epileptic zone. Importantly, the clinical manifestation of epilepsy, including seizure types, psychiatric comorbidities, and treatment responses, has been shown to differ between sexes. However, sex differences in structural alterations
Huantao Wen, Bin Wan, Taha Gholipour, Ke Xie, Judy Chen, Bianca Serio, Meike D. Hettwer, Marina K. M. Alvim, Donatello Arienzo, Rafael Batista João, Tobias Bauer, Andrea Bernasconi, Neda Bernasconi, Paolo Bonanni, Maria Eugenia Caligiuri, Fernando Cendes, Raphaël Christin, Luis Concha, Arielle Dascal, Edward Davoodi Boyd, Orrin Devinsky, Niels K. N. Focke, Francesco Fortunato, Marian Galovic, Antonio Gambardella, Renzo Guerrini, Sean N. Hatton, Mirana Iliza, Sara Inati, Victoria Ives‐Deliperi, Robert‐Paul Juster, Jonathan K. Kleen, Mohamad Z. Koubeissi, Angelo Labate, Sara Larivière, Meng Law, Matteo Lenge, Stefano Meletti, Patrick B. Moloney, Marlo Naish, Alexander Ngo, Terence J. O'Brien, Raluca Pana, Sofia Panzeri, Heath Pardoe, Erik H. U. Rauf, Antonella Riva, Raúl Rodríguez‐Cruces, Jessica Royer, Theodor Rüber, Ella Sahlas, Lucas Scárdua‐Silva, Kai Michael Schubert, Leigh N. Sepeta, Mariasavina Severino, Benjamin Sinclair, Hamid Soltanian‐Zadeh, Travis Stoub, Pasquale Striano, Sophia I. Thomopoulos, Nina V. Valientes, Anna Elisabetta Vaudano, Lucy Vivash, Clarissa L. Yasuda, Paul M. Thompson, Sanjay M. Sisodiya, Carrie R. McDonald, Boris C. Bernhardt, Sofie L. Valk   +68 more
wiley   +1 more source

Adeno‐associated virus‐mediated restoration of NaV1.1 in targeted brain regions ameliorates epilepsy in symptomatic Dravet syndrome mice

Epilepsia, EarlyView.
Abstract Objective Dravet syndrome (DS) is a developmental and epileptic encephalopathy primarily caused by haploinsufficiency of the SCN1A gene, which encodes the alpha subunit of NaV1.1 voltage‐gated sodium channel. The disease manifests with febrile and spontaneous seizures, developmental delay, cognitive impairment, and increased risk of sudden ...
Martina Mainardi, Simone Brusco, Serena Gea Giannelli, Vania Broccoli, Gaia Colasante   +4 more
wiley   +1 more source

From triggers to ictal events: A video case series of reflex seizures

Epileptic Disorders, EarlyView.
Laure Salmon, Nicolas Nguyen, Dang Khoa Nguyen, Olivier Aron   +3 more
wiley   +1 more source

Human induced pluripotent stem cell‐derived cortical neurons from monozygotic twins with the Gαo1K278del mutation reveal disease mechanisms relevant to GNAO1‐related encephalopathy

Epilepsia, EarlyView.
Abstract Objective Rare de novo variants in GNAO1 cause a severe neurodevelopmental disorder characterized by a heterogenous display of early onset epilepsy, movement abnormalities, and global developmental delay. More than 100 pathogenic variants in GNAO1 have been identified and categorized into four groups according to their protein features.
Maria Sáez González, Kes Kloosterhuis, Jeroen Vreijling, Hailiang Mei, Tom P. Hellings, Davide Pirolli, Anine H. Stam, Arn M. J. M. van den Maagdenberg, Vivi M. Heine, Jean‐Philippe Frimat, Laura A. van de Pol, Frank Baas, Harald M. M. Mikkers   +12 more
wiley   +1 more source

Effects of pharmacological modulation of cortical excitability on resting-state EEG PAC in humans. [PDF]

Sci Rep
Er A, Belardinelli P, Marchand-Pauvert V, Ziemann U, Marrelec G.   +4 more
europepmc   +1 more source

Increase of cortical excitability induced by pentazocine

Journal of Pharmacy and Pharmacology, 1980
R, Soto-Moyano, C, Paeile, A, Hernández
openaire   +2 more sources