Results 121 to 130 of about 68,479 (299)

Diabetes and the Metabolic Syndrome as Drivers of Neurodegeneration: Convergent Mechanisms Linking Peripheral Neuropathy and Dementia

Annals of Neurology, EarlyView.
The metabolic syndrome, a state of progressive metabolic dysfunction, injures the peripheral and central nervous systems, promoting peripheral neuropathy (PN) and cognitive impairment (CI), respectively. We posit PN and CI are connected in the metabolic syndrome framework, built on the premise that neurons, whether in the peripheral or central nervous ...
Masha G. Savelieff, David L. Bennett, Troels S. Jensen, Eva L. Feldman   +3 more
wiley   +1 more source

Double‐Limbed Medial Patellofemoral Ligament Reconstruction Using Knotless Femoral Fixation Technique

Arthroscopy Techniques, EarlyView.
Abstract This technical note describes using knotless femoral fixation for medial patellofemoral ligament reconstruction for skeletally immature patients. Using a knotless anchor for epiphyseal femoral fixation in the skeletally immature decreases the risk of irritable interference screw fixation and optimizes graft contact with host bone.
Henry B. Ellis, John E. Arvesen, Cody R. Todesco, Antonia L. Dinulescu, Benjamin L. Johnson, Charles W. Wyatt, Philip L. Wilson   +6 more
wiley   +1 more source

Interictal cortical excitability to magnetic stimulation in familial hemiplegic migraine

, 1997
We studied interictal cortical excitability with magnetic stimulation in controls, in patients with migraine with aura, and in patients with familial hemiplegic migraine (FHM), in which ictal hemiparesis occurs.
Ferrari, Michel D., Maassen van den Brink, Antoinette, van der Kamp, Wim, van Dijk, J. Gert   +3 more
core   +1 more source

Lower Striatal and Cortical Calretinin Interneuron Density Associated With Altered Social Behavior in Cntnap2 Knockout Mice

Autism Research, EarlyView.
ABSTRACT Variants in the CNTNAP2 gene, encoding the cell adhesion molecule CASPR2, have been identified as genetic risk factors for autism spectrum disorder (ASD). However, the mechanisms through which CNTNAP2 dysfunction alters circuit function remain unknown.
Krisztina Sáfár, Vivien Szendi, Paulina Hoppa, Yutong Wang, Fanni Á. Seres, Szilvia Bartók, Tyler Teadora, Lei Shi, Árpád Dobolyi, Gina Puska, István Adorján   +10 more
wiley   +1 more source

Beyond the Outburst: Charting a New Frontier for Understanding and Treating Irritability in Autistic Adults

Autism Research, EarlyView.
ABSTRACT Irritability is a prevalent and impairing feature associated with autism, yet remains poorly understood, particularly in adults. Drawing heavily on insights translated from pediatric and transdiagnostic literatures, we propose that irritability in autistic individuals often reflects a psychophysiological stress or threat response, rooted in a ...
Hsiang‐Yuan Lin, Arthur N. Westover, Amy S. F. Lutz, Manish K. Jha   +3 more
wiley   +1 more source

Impaired attentional modulation of sensorimotor control and cortical excitability in schizophrenia

, 2019
International audienceAbstract Impairments in attentional, working memory and sensorimotor processing have been consistently reported in schizophrenia.
Maier, Marc, Krebs, Marie-Odile, Guedj, Laura, Cuenca, Macarena, Carment, Loïc, Lindberg, Påvel, Térémetz, Maxime, Amado, Isabelle, Dupin, Lucile   +8 more
core   +1 more source

Sustained pharmacodynamic effects of S‐ketamine on cortical excitability and resting‐state brain activity: A randomized, placebo‐controlled trial

British Journal of Clinical Pharmacology, EarlyView.
Aims This study aimed to investigate a set of pharmacodynamic biomarkers reflecting acute, delayed and sustained central nervous system effects of S‐ketamine, used as a tool compound for rapid‐acting antidepressant activity, with the goal of informing biomarker strategies for delayed antidepressant effects.
Catherine M. K. E. de Cuba, Annika A. de Goede, Joost. C. van Mechelen, Laura G. J. M. Borghans, Liam van der Aa, Erik Olofsen, Maria J. Juachon, Robert J. Doll, Amy Gillespie, Catherine J. Harmer, Gabriël E. Jacobs, Jules A. A. C. Heuberger   +11 more
wiley   +1 more source

Cortical excitability in smoking and not smoking individuals with and without nicotine

, 2013
Activation of nicotinic acetylcholine receptors has a major neuromodulatory impact on central nervous system function. Beyond acute activation, chronic nicotine intake has long-lasting effects on cortical excitability in animal experiments, caused by ...
Freznosa, S., Paulus, Walter J., Nitsche, M. A., Grundey, Jessica, Lang, N., Klinker, Florian   +5 more
core   +1 more source

Neurovascular coupling in bone regeneration: Mechanisms, advanced biomaterials and challenges

BMEMat, EarlyView.
This figure illustrates various material strategies for neurovascularized bone regeneration, including electroactive scaffolds, ion‐loaded materials, drug delivery systems, surface modifications, cells/cell products, growth factors, and peptides. These approaches aim to synergistically promote the regeneration of neural, vascular, and bone tissues ...
Yixin Ma, Nan Jiang, Liyuan Chen, He Zhang, Xinjia Cai, Karan Gulati, Danqing He, Zhigang Cai, Yan Liu   +8 more
wiley   +1 more source

Video1_Bring the pain: wounding reveals a transition from cortical excitability to epithelial excitability in Xenopus embryos.AVI

The cell cortex plays many critical roles, including interpreting and responding to internal and external signals. One behavior which supports a cell’s ability to respond to both internal and externally-derived signaling is cortical excitability, wherein
Leslie A. Sepaniac (18008230), William M. Bement (12987448), Nicholas R. Davenport (18008233)   +2 more
core   +1 more source