Results 141 to 150 of about 68,657 (264)

Sustained pharmacodynamic effects of S-ketamine on cortical excitability and resting-state brain activity: A randomized, placebo-controlled trial. [PDF]

Br J Clin Pharmacol
de Cuba CMKE, de Goede AA, van Mechelen JC, Borghans LGJM, van der Aa L, Olofsen E, Juachon MJ, Doll RJ, Gillespie A, Harmer CJ, Jacobs GE, Heuberger JAAC.   +11 more
europepmc   +1 more source

Absence seizures: Update on signaling mechanisms and networks

Epilepsia Open, EarlyView.
Abstract Absence seizures (AS) are a hallmark of genetic generalized epilepsies (GGE), characterized by brief episodes of impaired consciousness accompanied by electroencephalographic spike‐and‐wave discharges (SWDs). Traditionally attributed to cortico‐thalamo‐cortical (CTC) dysrhythmia, emerging evidence suggests a more intricate pathophysiological ...
Ozlem Akman, Filiz Onat
wiley   +1 more source

Transcranial Magnetic Stimulation Combined With Electroencephalography Analysis Suggest Time-Dependent and Region-Specific Modulation of Cortical Excitability During Acute Alcohol Intoxication. [PDF]

Alcohol Clin Exp Res (Hoboken)
Kekkonen V, Fonsén E, Kallioniemi E, Säisänen L, Tolmunen T, Könönen M, Kivimäki P, Määttä S.   +7 more
europepmc   +1 more source

Status epilepticus: Updates on mechanisms and treatments

Epilepsia Open, EarlyView.
Abstract Status epilepticus (SE) consists of prolonged, self‐sustaining seizures and is a common neurological emergency that causes respiratory compromise and neuronal injury. Without prompt treatment, the seizures can become resistant to benzodiazepines, leading to the progressive evolution of established, refractory, and super‐refractory SE.
Suchitra Joshi, Jaideep Kapur
wiley   +1 more source

Ketogenic diet for infantile epileptic spasms

Epilepsia Open, EarlyView.
Abstract Approximately half of all cases of Infantile Epileptic Spasms Syndrome (IESS) do not respond to vigabatrin and hormonal therapies. There is no clear consensus as to the second‐line therapy for IESS. Ketogenic diet (KD) has emerged as an effective treatment for certain drug‐resistant epilepsies and in many cases of IESS.
Morris H. Scantlebury, Anamika Choudhary, Andy Cheuk‐Him Ng, Cezar Gavrilovici   +3 more
wiley   +1 more source

Polarity-dependent modulation of sleep oscillations and cortical excitability in aging. [PDF]

Front Aging Neurosci
Dikici B, Malinowski R, Kordaß JB, Obermayer K, Ladenbauer J, Flöel A.   +5 more
europepmc   +1 more source

Neonatal seizures and GABAergic drugs: Scylla and Charybdis?

Epilepsia Open, EarlyView.
Abstract Neonates have a high incidence of seizures that are frequently difficult to control with conventional first‐line anti‐seizure medications, which are gamma‐aminobutyric acid (GABA) agonists. The reasons for this clinical problem are multifold but are likely related to the unique physiology of the immature nervous system. Specifically, the early
Kerry W. Thompson, Lucie Suchomelova, Claude G. Wasterlain   +2 more
wiley   +1 more source

Cortical excitability mapping stratifies neurobiological subtypes of schizophrenia with genetic and molecular signatures. [PDF]

BMC Med
Guo S, Zhao Y, Ji X, Liu X, Li L, Guo Y, Zhang X, Xie R, Zeng J, Sun H, Lui S, Gong Q.   +11 more
europepmc   +1 more source

Auditory gamma‐band synchronization and attentional performance in juvenile myoclonic epilepsy

Epilepsia Open, EarlyView.
Abstract Objective Cognitive difficulties in juvenile myoclonic epilepsy (JME) are part of the clinical phenotype alongside epileptic seizures; however, the underlying neurophysiological mechanisms remain unclear. Auditory steady‐state responses (ASSRs) to repetitive 40‐ and 80‐Hz stimuli are widely used measures of gamma‐band oscillations (GBOs ...
Ryo Mitoma, Shunsuke Tamura, Yoji Hirano, Takako Mitsudo, Yubin Sung, Takahiko Mukaino, Takahiro Yamaguchi, Kou Matsumoto, Toshiaki Onitsuka, Shogo Hirano, Tomohiro Nakao, Noriko Isobe, Hiroshi Shigeto   +12 more
wiley   +1 more source

EEG CONNECT: A proposed reporting checklist for EEG‐based connectivity studies in clinical epilepsy research

Epilepsia Open, EarlyView.
Abstract EEG‐based connectivity analysis has emerged as a promising approach for investigating brain network dynamics in clinical epilepsy research. However, the diversity of analytical approaches, preprocessing pipelines, and reporting practices poses challenges to reproducibility and clinical translation.
Naoto Kuroda, Ethan Firestone, Giulia Sofia Cereda, Jesús Servando Medel‐Matus, Pedro F. Viana, Aristea S. Galanopoulou, Eishi Asano   +6 more
wiley   +1 more source