Results 81 to 90 of about 1,585,655 (272)

Altered network properties in C9ORF72 repeat expansion cortical neurons are due to synaptic dysfunction

Molecular Neurodegeneration, 2021
Background Physiological disturbances in cortical network excitability and plasticity are established and widespread in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) patients, including those harbouring the C9ORF72 repeat ...
Emma M. Perkins, Karen Burr, Poulomi Banerjee, Arpan R. Mehta, Owen Dando, Bhuvaneish T. Selvaraj, Daumante Suminaite, Jyoti Nanda, Christopher M. Henstridge, Thomas H. Gillingwater, Giles E. Hardingham, David J. A. Wyllie, Siddharthan Chandran, Matthew R. Livesey   +13 more
doaj   +1 more source

The role of the proto-oncogene Ski in cortical development [PDF]

, 2013
The proto-oncogene Ski is an evolutionary conserved protein associated with various cellular processes such as proliferation and differentiation as well as transformation and tumor progression.
Baranek, Constanze Katharina Charlotte
core   +1 more source

Cognitive and Neuroimaging Divergence Between Juvenile and Adult FUS Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by progressive motor neuron degeneration. Fused in sarcoma (FUS)‐associated juvenile ALS (jALS) represents a distinct and aggressive subgroup with rapid deterioration and poor prognosis.
Alexandra V. Jürs, Marcel Naumann, Annaliis Lehto, Hanna Schön, Jens Kurth, Johannes Prudlo, Andreas Hermann, Elisabeth Kasper   +7 more
wiley   +1 more source

Reconsideration of the Effects of Age on Proximal Femur Structure: Implications for Joint Replacement and Hip Fracture.

PLoS ONE, 2016
ObjectivesIn recent years quantitative computed tomography (QCT) has allowed precise non-invasive, three dimensional, in vivo measurement of hip structure in large numbers of individuals. The effects of ageing on proximal femur structure are reported and
B C C Khoo, J K Brown, R L Prince
doaj   +1 more source

Digital Cognitive Phenotyping for Differential Diagnosis and Monitoring in Neurological Conditions

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To assess the utility, accessibility, and equivalence to supervised scales of online cognitive assessment in older individuals with cognitive impairment. Methods Patients with Alzheimer's disease (AD, n = 31), idiopathic normal pressure hydrocephalus (iNPH, n = 26), and traumatic brain injury (TBI, n = 23) completed online cognitive ...
Martina Del Giovane, Valentina Giunchiglia, Michael C. B. David, Magdalena A. Kolanko, William R. Trender, Peter J. Hellyer, Harmeena Kaur, David J. Sharp, Christopher Carswell, Paresh A. Malhotra, Adam Hampshire   +10 more
wiley   +1 more source

Follow-up study of subventricular zone progenitors with multiple rounds of cell division during sulcogyrogenesis in the ferret cerebral cortex

IBRO Reports, 2019
The subventricular zone (SVZ) of the developing cerebral cortex appears transiently during cortical neurogenesis and is known as the second proliferative zone that contains intermediate progenitor cells and self-renewable neuronal stem cells—the so ...
Kazuhiko Sawada
doaj   +1 more source

Coordinated optimization of visual cortical maps : 1. Symmetry-based analysis [PDF]

, 2012
In the primary visual cortex of primates and carnivores, functional architecture can be characterized by maps of various stimulus features such as orientation preference (OP), ocular dominance (OD), and spatial frequency.
Heide, Dominik, Justin C. Crowley (120185), Wolf, Fred, Dominik Heide, Fred Wolf, Matthias Kaschube, Heide, D., Löwel, Siegrid, Crowley, Justin C., Kaschube, Matthias, Dominik Heide (120181), Reichl, L., Kaschube, M., Justin C Crowley, Reichl, Lars, Löwel, S., Lars Reichl, Lars Reichl (120178), Siegrid Löwel, Wolf, F., Siegrid Löwel (53603), Fred Wolf (120189), Crowley, J., Matthias Kaschube (120187)   +23 more
core   +1 more source

Thalamo‐Lesional Connectivity Signatures of Bilateral Tonic–Clonic Seizures in Focal Cortical Dysplasia‐Related Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Focal cortical dysplasia (FCD) is the most common etiology of drug‐resistant epilepsy in children. Focal to bilateral tonic–clonic seizures (FBTCS) mark a high risk of drug‐resistant epilepsy and involve thalamocortical circuitry in their generation and propagation.
Hua Xie, Xiaotong Li, Venkata Sita Priyanka Illapani, Leigh N. Sepeta, Jason Schroeder, Chima O. Oluigbo, Madison M. Berl, William D. Gaillard, Nathan T. Cohen   +8 more
wiley   +1 more source

Dissecting the molecular mechanism underlying the intimate relationship between cellulose microfibrils and cortical microtubules

Frontiers in Plant Science, 2014
A central question in plant cell development is how the cell wall determines directional cell expansion and therefore the final shape of the cell. As the major load-bearing component of the cell wall, cellulose microfibrils are laid down transversely to ...
Lei eLei, Shundai eLi, Logan eBashline, Ying eGu   +3 more
doaj   +1 more source

Supersize me—new insights into cortical expansion and gyration of the mammalian brain

The EMBO Journal, 2013
During evolution, the mammalian brain massively expanded its size. However, the exact roles of distinct neural precursors, identified in the developing cortex during embryogenesis, for size expansion and surface folding (i.e., gyration) remain largely unknown.
Ghosh Laboni, Jessberger Sebastian
openaire   +5 more sources