Results 61 to 70 of about 1,585,655 (272)

Abnormal cortical development after premature birth shown by altered allometric scaling of brain growth. [PDF]

, 2006
BACKGROUND: We postulated that during ontogenesis cortical surface area and cerebral volume are related by a scaling law whose exponent gives a quantitative measure of cortical development.
Ajayi-Obe, M., Nadeem Saeed, Allsop, J. M., Boardman, J., Kennea, N, Morenike Ajayi-Obe, Dyet, L., Jaroslav Stark, Frances Cowan, Saeed Nadeem, Philip Duggan, Allsop Joanna M, Counsell, S. J.; id_orcid, Kennea, N., Ajayi-Obe Morenike, Stark, J., Edwards, AD, Cowan, F, Mary A Rutherford, Joanna M Allsop, Dyet Leigh, Counsell Serena J, Counsell, SJ, Stark, J, Kennea Nigel, Duggan Philip, Maalouf, E, Allsop, JM, Kapellou, O, Jo Hajnal, Leigh Dyet, Rutherford, M. A., Rutherford, MA, Duggan, P., Edwards, A. D.; id_orcid, Ajayi-Obe, M, Maalouf Elia, A David Edwards, Maalouf, E., Boardman James, Cowan, F., Hajnal, J.; id_orcid, Saeed, N, Dyet, L, James Boardman, Cowan Frances, Edwards A. David, Duggan, P, Rutherford Mary A, Hajnal Jo, Elia Maalouf, Olga Kapellou, Kapellou, O., Serena J Counsell, Saeed, N., Hajnal, J, Stark Jaroslav, Boardman, J, Nigel Kennea, Kapellou Olga, Rutherford, M. A.; id_orcid   +60 more
core   +1 more source

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

Cortical Dynamics of Contact Expansion [PDF]

Biophysical Journal, 2021
Feyza Nur Arslan, Martin Loose, Carl-Philipp Heisenberg   +2 more
openaire   +1 more source

A mechanical method of cerebral cortical folding development based on thermal expansion [PDF]

Scientific Reports, 2019
Abstract Cortical folding malformations are associated with several severe neurological disorders, including epilepsy, schizophrenia and autism. However, the mechanism behind cerebral cortical folding development is not yet clear. In this paper, we propose a mechanical method based on thermal expansion to simulate the development of ...
Linlin Wang, Jianyao Yao, Ning Hu
openaire   +2 more sources

Quantitative Ultrasound of Cortical Bone in the Femoral Neck Predicts Femur Strength: Results of a Pilot Study [PDF]

, 2013
Article first published online: 15 JAN 2013 Pour consulter la version éditeur DOI: 10.1002/jbmr.1742A significant risk of femoral neck (FN) fracture exists for men and women with an areal bone mineral density (aBMD) higher than the osteoporotic range ...
GRONDIN, Julien, ENGELKE, Klaus, Reinhard Barkmann, GRIMAL, Quentin, Quentin Grimal, Sandra Guérard, Glüer, Claus-C., Julien Grondin, GUÉRARD, Sandra, Klaus Engelke, GLÜER, Claus-C, BARKMANN, Reinhard, Claus‐C Glüer, Pascal Laugier, LAUGIER, Pascal   +14 more
core   +1 more source

Dactolisib outperforms Rapamycin in potentiating apoptosis induced by XPO1, Bcl‐2 and Mcl‐1 blockade in preclinical glioblastoma models

FEBS Open Bio, EarlyView.
The PAM pathway and its impact on cellular metabolism. Color‐coded key symbols represent Rapamycin (R, orange, targeting mTOR) and Dactolisib (D, green, targeting PI3K/mTOR), indicating their sites of action. Created with BioRenders.com. Glioblastoma resists therapy through interconnected survival programs.
Kai Zhao, Leonie Meyer, Madita Braun, Katharina Otte, Celine Bitter, Maite Pawlik, Hartmann Raifer, Frederik Helmprobst, Axel Pagenstecher, Hans Urban, Michael C. Burger, Michael W. Ronellenfitsch, Joachim P. Steinbach, Jarmila Jedelská, Shamim Bagheri, Behrooz H. Yousefi, Pietro Di Fazio, Markus Luster, Andreas H. Mahnken, Andreas Neubauer, Andreas Burchert, Christopher Nimsky, Jörg W. Bartsch, Tillmann Rusch   +23 more
wiley   +1 more source

Understanding Further the Phenotypic Spectrum of Central Nervous System Inflammatory Demyelinating Disorders Using Unsupervised Clustering

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Central nervous system (CNS) inflammatory demyelinating syndromes, including multiple sclerosis (MS), aquaporin‐4 antibody–positive neuromyelitis optica spectrum disorder (AQP4 + NMOSD), and myelin oligodendrocyte glycoprotein (MOG) antibody–associated disease (MOGAD), occasionally overlap.
Bade Gulec, Elif Everest, Melih Tutuncu, Ugur Bilge, Sabahattin Saip, Ugur Uygunoglu, Aksel Siva   +6 more
wiley   +1 more source

Generation of human cerebral organoids with a structured outer subventricular zone

Cell Reports
Summary: Outer radial glia (oRG) emerge as cortical progenitor cells that support the development of an enlarged outer subventricular zone (oSVZ) and the expansion of the neocortex.
Ryan M. Walsh, Raffaele Luongo, Elisa Giacomelli, Gabriele Ciceri, Chelsea Rittenhouse, Antonietta Verrillo, Maura Galimberti, Vittoria Dickinson Bocchi, Youjun Wu, Nan Xu, Simone Mosole, James Muller, Elena Vezzoli, Johannes Jungverdorben, Ting Zhou, Roger A. Barker, Elena Cattaneo, Lorenz Studer, Arianna Baggiolini   +18 more
doaj   +1 more source

Comparing the Effect of Semi‐Immersive Virtual Reality, Computerized Cognitive Training, and Traditional Rehabilitation on Cognitive Function in Multiple Sclerosis: A Randomized Clinical Trial

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Cognitive impairment is a common non‐motor symptom in Multiple Sclerosis (MS), negatively affecting autonomy and Quality of Life (QoL). Innovative rehabilitation strategies, such as semi‐immersive virtual reality (VR) and computerized cognitive training (CCT), may offer advantages over traditional cognitive rehabilitation (TCR ...
Maria Grazia Maggio, Desiree Latella, Lilla Bonanno, Paulo Cezar Rocha dos Santos, Marcos Maldonado‐Díaz, Meir Plotnik, Rosaria De Luca, Angelo Quartarone, Rocco Salvatore Calabrò   +8 more
wiley   +1 more source

Comprehensive Assessment of Arterial, Tissue, and Venous Collaterals for Evaluating the Infarct Growth Rate: The Multimodal Collateral Score

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Collaterals are crucial factors that influence the infarct growth rate (IGR). We aimed to determine whether a comprehensive multimodal collateral score (MCS), incorporating collateral assessment at the arterial, tissue, and venous levels, is associated with functional independence and provides incremental prognostic value over ...
Giorgio Busto, Umberto Pensato, Ilaria Casetta, Giorgio U. Marcello, Angelo Barra, Anna Poggesi, Edoardo Carlesi, Sara Mancini, Andrea Ginestroni, Vittorio Miele, Alessandro Padovani, Andrea Morotti, Enrico Fainardi   +12 more
wiley   +1 more source