Results 231 to 240 of about 462,073 (262)

Mitochondrial Protection and Neural Repair via ROS‐Responsive Biomimetic Nanoparticles in Intracerebral Hemorrhage

Advanced Science, EarlyView.
A ROS‐responsive biomimetic nanoparticle platform co‐delivers DIDS and Mdivi‐1 to protect mitochondria and promote neural repair after intracerebral hemorrhage. By targeting LPAR1/VDAC1‐related mitochondrial dysfunction, the nanotherapy reduces oxidative injury, neuronal apoptosis, and blood‐brain barrier disruption, improving neurological recovery and
Ling Gao, Li Peng, Xiaobin Zheng, Cong Tan, Chuang Wang, Qijiang Xiong, Weiming Chen, Zhao Yang   +7 more
wiley   +1 more source

PBRM1 Deficiency in Microglia Leads to Excessive Neurogenesis and Autism‐Like Behaviors via the CCL5‐CCR1/5‐β‐catenin Signaling Axis

Advanced Science, EarlyView.
Microglial PBRM1 deficiency drives excessive hippocampal neurogenesis by enhancing CCL5–CCR1/5 signaling, leading to autism‐like behaviors. A pro‐inflammatory IL1α+/TNFα+ microglial subset is identified as a key cellular contributor to this process. PBRM1 represses Ccl5 expression at the transcriptional level.
Yang‐Yang Duan, Lin‐Fei Jiao, Pei‐Pei Liu, Chun‐Hui Duan, Xiao Li, Zi‐Han Zhang, Yue‐Qi Zhang, Xin‐Li Ouyang, Hong‐Zhen Du, Sha Liu, Yi Tang, Zhao‐Qian Teng, Chang‐Mei Liu   +12 more
wiley   +1 more source

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Physical aspects of cortical folding

Soft Matter, 2021
Swelling polymers reveal that a wrinkling instability with subsequent transition into folding seems to be the driving physical mechanism of cortical folding in the human brain.
Alexander Greiner, Stefan Kaessmair, Silvia Budday   +2 more
openaire   +2 more sources

Biomechanisms for Modelling Cerebral Cortical Folding

Medical Image Analysis, 2009
Understanding the biomechanical mechanisms by which the cerebral cortex folds is a fundamental problem in neuroscience. Current mathematical models of cortical folding do not include three dimensional geometry or measurement of cortical growth in developing brains extracted from experimental data. We present two biomechanical models of cortical folding
Gary F. Egan, David W Walker, Leigh A. Johnston   +2 more
exaly   +4 more sources

Development of Cortical Folding During Evolution and Ontogeny

Trends in Neurosciences, 2013
Cortical folding is a hallmark of many, but not all, mammalian brains. The degree of folding increases with brain size across mammals, but at different scales between orders and families. In this review we summarize recent studies that have shed light on cortical folding and discuss new models that arise from these data.
Katrin Amunts, Karl Zilles, Nicola Palomero-Gallagher   +2 more
exaly   +3 more sources

Increased White Matter Radial Diffusivity Is Associated With Prefrontal Cortical Folding Deficits in Schizophrenia

Psychiatry Research - Neuroimaging, 2017
The neuronal underpinnings of cortical folding alterations in schizophrenia remain unclear. Theories on the physiological development of cortical folds stress the importance of white matter fibers for this process and disturbances of fiber tracts might ...
Jürgen R Reichenbach, Gerd Wagner, Kathrin Koch   +2 more
exaly   +2 more sources

Classification Based on Cortical Folding Patterns

IEEE Transactions on Medical Imaging, 2007
We describe here a classification system based on automatically identified cortical sulci. Multivariate recognition methods are required for the detection of complex brain patterns with a spatial distribution. However, such methods may face the well-known issue of the curse of dimensionality-the risk of overfitting the training dataset in high ...
Edouard Duchesnay, Arnaud Cachia, Alexis Roche, Denis Rivière, Yann Cointepas, Dimitri Papadopoulos-Orfanos, Monica Zilbovicius, Jean-Luc Martinot, Jean Régis, Jean-François Mangin   +9 more
openaire   +3 more sources

Individual Identification and Individual Variability Analysis Based on Cortical Folding Features in Developing Infant Singletons and Twins [PDF]

Human Brain Mapping, 2020
Studying the early dynamic development of cortical folding with remarkable individual variability is critical for understanding normal early brain development and related neurodevelopmental disorders.
Islem Rekik, Shunren Xia, Li Wang
exaly   +2 more sources

Gyral Net: A New Representation of Cortical Folding Organization [PDF]

Medical Image Analysis, 2017
One distinct feature of the cerebral cortex is its convex (gyri) and concave (sulci) folding patterns. Due to the remarkable complexity and variability of gyral/sulcal shapes, it has been challenging to quantitatively model their organization patterns ...
Dinggang Shen, Tianming Liu, Yujie Li
exaly   +2 more sources

Differential features of cortical folds

1997
Analysis of functional images of the brain increasingly relies on individual anatomy of subjects. The aim is the construction of accurate anatomy-indexed functional mappings which would be of crucial importance for neurosurgical planning. The major difficulty relies in the important inter-subject structural variability of the cortical anatomy.
Anne Manceaux-Demiau, Jean-François Mangin, Jean Régis, Olivier Pizzato, Vincent Frouin   +4 more
openaire   +2 more sources