Results 1 to 10 of about 5,539,416 (160)

Ethanol exposure disrupted the formation of radial glial processes and impaired the generation and migration of outer radial glial cells in forebrain organoids derived from human embryonic stem cells. [PDF]

Exp Neurol, 2023
Radial glial cells (RGCs) play a pivotal role in cerebral cortical development by functioning as a source of new neurons and by supporting the migration of newborn neurons. These functions are primarily dependent on the apical-basolateral structures of radial glial processes.
Lü L, Yuan F, Fan H, Li Y, Liu J, Feng W, Zhang HG, Chen SY.   +7 more
europepmc   +5 more sources

Brain organoid models of SZT2-related disease reveal an overproduction of outer radial glial cells through mTORC1 activation [PDF]

Scientific Reports
Biallelic loss-of-function variants of Seizure Threshold 2 (SZT2) cause neurodevelopmental diseases with developmental delay, epilepsy, and macrocephaly.
Emi Sato, Yuji Nakamura, Masanori Fujimoto, Issei S. Shimada, Toshihiko Iwaki, Daisuke Ieda, Yutaka Negishi, Ayako Hattori, Yoichi Kato, Shinji Saitoh   +9 more
doaj   +7 more sources

Mitotic spindle orientation predicts outer radial glial cell generation in human neocortex [PDF]

Nature Communications, 2013
The human neocortex is increased in size and complexity as compared with most other species. Neocortical expansion has recently been attributed to protracted neurogenesis by outer radial glial cells in the outer subventricular zone, a region present in humans but not in rodents.
LaMonica, Bridget, Lui, Jan, Hansen, David, Kriegstein, Arnold   +3 more
exaly   +9 more sources

Lzts1 controls both neuronal delamination and outer radial glial-like cell generation during mammalian cerebral development [PDF]

Nature Communications, 2019
Outer radial glial cells (oRGs) are undifferentiated cells that divide in the subventricular zone during neurodevelopment, but the underlying mechanisms are not fully understood.
T. Kawaue, A. Shitamukai, A. Nagasaka, Y. Tsunekawa, T. Shinoda, K. Saito, R. Terada, M. Bilgic, T. Miyata, F. Matsuzaki, A. Kawaguchi   +10 more
doaj   +5 more sources

Enhanced cortical neural stem cell identity through short SMAD and WNT inhibition in human cerebral organoids facilitates emergence of outer radial glial cells. [PDF]

Nat Cell Biol, 2022
Abstract Cerebral organoids exhibit broad regional heterogeneity accompanied by limited cortical cellular diversity despite the tremendous upsurge in derivation methods, suggesting inadequate patterning of early neural stem cells (NSCs).
Rosebrock D, Arora S, Mutukula N, Volkman R, Gralinska E, Balaskas A, Aragonés Hernández A, Buschow R, Brändl B, Müller FJ, Arndt PF, Vingron M, Elkabetz Y.   +12 more
europepmc   +4 more sources

Control of Outer Radial Glial Stem Cell Mitosis in the Human Brain [PDF]

Cell Reports, 2014
Evolutionary expansion of the human neocortex is partially attributed to a relative abundance of neural stem cells in the fetal brain called outer radial glia (oRG). oRG cells display a characteristic division mode, mitotic somal translocation (MST), in which the soma rapidly translocates toward the cortical plate immediately prior to cytokinesis.
Ostrem, Bridget EL, Lui, Jan H, Gertz, Caitlyn C, Kriegstein, Arnold R   +3 more
openaire   +6 more sources

Molecular signatures and lineage diversification of neurogenic and gliogenic radial glia in the gyrencephalic ferret cortex [PDF]

Communications Biology
Human exceptional cognition stems from evolutionarily derived cortical adaptations that drive expansive neurogenesis. In this study, we employ the gyrencephalic ferret model to systematically characterize the molecular profiles and lineage dynamics of ...
Jialin Li, Feihong Yang, Weiwei Li, Tongye Fu, Zhenmeiyu Li, Zizhuo Sha, Wenhui Zheng, Chuannan Yang, Jingzhe Yu, Danyu Han, Xin Jiang, Yan You, Xiaosu Li, Tong Ma, Miao He, Zhejun Xu, Xiaolei Song, Bin Chen, Jing Ding, Xin Wang, Zhuangzhi Zhang, Zhengang Yang   +21 more
doaj   +2 more sources

The expression of aristaless-related homeobox in neural progenitors of gyrencephalic carnivore ferrets

Biochemistry and Biophysics Reports, 2021
Aristaless-related homeobox (ARX) has important functions in the development of various organs including the brain. Mutations of the human ARX gene have been associated with malformations of the cerebral cortex such as microcephaly and lissencephaly ...
Hiroki Maeyama, Yohei Shinmyo, Hiroshi Kawasaki   +2 more
doaj   +1 more source

Changes in the Localization of Polyamine Spermidine in the Rat Retina with Age

Biomedicines, 2023
Polyamines (PAs) in the nervous system has a key role in regeneration and aging. Therefore, we investigated age-related changes in the expression of PA spermidine (SPD) in the rat retina.
David S. Ríos, Christian J. Malpica-Nieves, Amanda Díaz-García, Misty J. Eaton, Serguei N. Skatchkov   +4 more
doaj   +1 more source

Exploring the role of the outer subventricular zone during cortical folding through a physics-based model

eLife, 2023
The human brain has a highly complex structure both on the microscopic and on the macroscopic scales. Increasing evidence has suggested the role of mechanical forces for cortical folding – a classical hallmark of the human brain.
Mohammad Saeed Zarzor, Ingmar Blumcke, Silvia Budday   +2 more
doaj   +1 more source