Results 11 to 20 of about 5,539,416 (160)
mTOR signaling regulates the morphology and migration of outer radial glia in developing human cortex [PDF]
eLife, 2020 Outer radial glial (oRG) cells are a population of neural stem cells prevalent in the developing human cortex that contribute to its cellular diversity and evolutionary expansion.
Madeline G Andrews +2 more
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A Müller Glia-Retinal Pigment Epithelium Apical Network Surrounding Cone Outer Segments in Fish and Mouse. [PDF]
GliaMüller glia and the retinal pigment epithelium interact around cone outer segment in the subretinal space of both zebrafish and mouse. The contacts are established early during development but subsequent to outer segment emergence. ABSTRACT Homeostasis of the vertebrate retina critically depends on two non‐neuronal cell populations, Müller glia and the
Sharkova M +6 more
europepmc +2 more sources
Modeling of Hypoxic Brain Injury through 3D Human Neural Organoids
Cells, 2021 Brain organoids have emerged as a novel model system for neural development, neurodegenerative diseases, and human-based drug screening. However, the heterogeneous nature and immature neuronal development of brain organoids generated from pluripotent ...
Min Soo Kim +5 more
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Neuronal Delamination and Outer Radial Glia Generation in Neocortical Development
Frontiers in Cell and Developmental Biology, 2021 During neocortical development, many neuronally differentiating cells (neurons and intermediate progenitor cells) are generated at the apical/ventricular surface by the division of neural progenitor cells (apical radial glial cells, aRGs).
Ayano Kawaguchi
doaj +1 more source
The CTNNBIP1-CLSTN1 fusion transcript regulates human neocortical development
Cell Reports, 2021 Summary: Fusion transcripts or RNAs have been found in both disordered and healthy human tissues and cells; however, their physiological functions in the brain development remain unknown. In the analysis of deposited RNA-sequence libraries covering early
Min-Yi Ou +6 more
doaj +1 more source
eLife, 2020 An increase in the diversity of neural progenitor subtypes and folding of the cerebral cortex are characteristic features which appeared during the evolution of the mammalian brain.
Naoyuki Matsumoto +4 more
doaj +1 more source
, 2022 Abstract Cerebral organoids display broad regional heterogeneity and limited capacity to generate cortical cell diversity due to incompetent patterning signals within early developing organoid neural stem cells (NSCs). Here we describe a method to overcome this limitation by applying a short and early dual SMAD/WNT inhibition course, which ...
Yechiel Elkabetz +4 more
openaire +1 more source
Mechanistic target of rapamycin signaling in human nervous system development and disease
Frontiers in Molecular Neuroscience, 2022 Mechanistic target of rapamycin (mTOR) is a highly conserved serine/threonine kinase that regulates fundamental cellular processes including growth control, autophagy and metabolism. mTOR has key functions in nervous system development and mis-regulation
Marie Girodengo +3 more
doaj +1 more source
Outer brain barriers in rat and human development
Frontiers in Neuroscience, 2015 Complex barriers at the brain’s surface, particularly in development, are poorly defined. In the adult, arachnoid blood-cerebrospinal fluid (CSF) barrier separates the fenestrated dural vessels from the CSF by means of a cell layer joined by tight ...
Christian Beltoft Brøchner +2 more
doaj +1 more source
Comparative analysis of the subventricular zone in rat, ferret and macaque: evidence for an outer subventricular zone in rodents. [PDF]
PLoS ONE, 2012 The mammalian cerebral cortex arises from precursor cells that reside in a proliferative region surrounding the lateral ventricles of the developing brain.
Verónica Martínez-Cerdeño +7 more
doaj +1 more source