Conditional activation of Bmi1 in embryonic and postnatal neural stem/progenitor cells in mouse models: analysis of its effect on their biological properties and tumourigenesis [PDF]
PhDThe Polycomb group protein Bmi1 is a key transcriptional regulator of self renewal of embryonic and adult neural stem and progenitor cells (NSPC) and its over-expression has been shown to occur in several types of brain tumour.
Yadırgı, Gökhan
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Early evolution of radial glial cells in Bilateria [PDF]
Bilaterians usually possess a central nervous system, composed of neurons and supportive cells called glial cells. Whereas neuronal cells are highly comparable in all these animals, glial cells apparently differ, and in deuterostomes, radial glial cells ...
Kuhrt, Heidrun +21 more
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Cellular and Molecular Mechanisms regulating Cell Proliferation during the Forebrain Development of the Mouse [PDF]
The predominant precursor cell type during cortical neurogenesis are radial glia cells, which receive extrinsic and intrinsic signals that might influence cell proliferation and neurogenesis.
Haubst, Nicole, Haubst, N.
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OBJECTIVES/SPECIFIC AIMS: Müller cells, radial glial cells of the retina, are the principal repository of xanthophyll pigment (lutein, zeaxanthin, meso-zeaxanthin), which are modifiable by diet and visible clinically by autofluorescence imaging.
Ramya Singireddy +4 more
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Niche-independent symmetrical self-renewal of a mammalian tissue stem cell. [PDF]
Pluripotent mouse embryonic stem (ES) cells multiply in simple monoculture by symmetrical divisions. In vivo, however, stem cells are generally thought to depend on specialised cellular microenvironments and to undergo predominantly asymmetric divisions.
Luciano Conti +68 more
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Neurogliogenesis and visual system development in "Drosophila" : genetic/genomic analysis of the "Glial cells missing" and "Egghead" genes [PDF]
Complex nervous systems are made up by two major cell types, neuronal and glial cell types. A general observation that has been made by lineage analysis of neurogliogenesis in vertebrates and invertebrates is that neurons and glia often share common ...
Fan, Yun
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Ion activities and potassium uptake mechanisms of glial cells in guinea-pig olfactory cortex slices. [PDF]
1. Double-barrelled ion-sensitive micro-electrodes were used to measure changes in the intracellular activities of K+, Na+ and Cl- (aiK, aiNa, aiCl) in glial cells of slices from guinea-pig olfactory cortex during repetitive stimulation of the lateral ...
Ballanyi, Klaus +2 more
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Tight junction protein occludin regulates progenitor Self-Renewal and survival in developing cortex
Occludin (OCLN) mutations cause human microcephaly and cortical malformation. A tight junction component thought absent in neuroepithelium after neural tube closure, OCLN isoform-specific expression extends into corticogenesis.
Raphael M Bendriem +4 more
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Mouse embryonic stem cells as a discovery tool in neurobiology [PDF]
Mouse ES cells can recapitulate, under suitable tissue culture conditions, early events in neurogenesis. As wildtype or genetically modified ES cells can be grown in unlimited quantities, their differentiation into neurons represents an attractive model
Nikoletopoulou, Vassiliki
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Radial glial cells defined and major intermediates between embryonic stem cells and CNS neurons
Radial glial cells have been identified as a major source of neurons during development. Here, we review the evidence for the distinct "glial" nature of radial glial cells and contrast these cells with their progenitors, the neuroepithelial cells. Recent
Barde, Yves-Alain +4 more
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