mTOR Signaling Regulates the Morphology and Migration of Outer Radial Glia in Developing Human Cortex. [PDF]
ELife, 2020 Outer radial glial (oRG) cells are a population of neural stem cells prevalent in the developing human cortex that contribute to its cellular diversity and evolutionary expansion.
Arnold Kriegstein +2 more
exaly +10 more sources
Outer Radial Glia Promotes White Matter Regeneration After Neonatal Brain Injury [PDF]
Cell Reports MedicineSummary: The developing gyrencephalic brain contains a large population of neural stem cells in the ventricular zone and outer subventricular zone (OSVZ), the latter populated by outer radial glia (oRG).
Vittorio Gallo +2 more
exaly +7 more sources
Molecular Identity of Human Outer Radial Glia During Cortical Development [PDF]
Cell, 2015 Radial glia, the neural stem cells of the neocortex, are located in two niches: the ventricular zone and outer subventricular zone. Although outer subventricular zone radial glia may generate the majority of human cortical neurons, their molecular features remain elusive.
Arnold Kriegstein +2 more
exaly +8 more sources
Valproic Acid Exposure Decreases Neurogenic Potential of Outer Radial Glia in Human Brain Organoids [PDF]
Frontiers in Molecular Neuroscience, 2022 Valproic acid (VPA) exposure during pregnancy leads to a higher risk of autism spectrum disorder (ASD) susceptibility in offspring. Human dorsal forebrain organoids were used to recapitulate course of cortical neurogenesis in the developing human brain ...
Zhenle Zang, Zhulin Du, Liuyongwei Wang
exaly +6 more sources
Outer Radial Glia-Like Cancer Stem Cells Contribute to Heterogeneity of Glioblastoma [PDF]
Cell Stem Cell, 2020 Glioblastoma is a devastating form of brain cancer. To identify aspects of tumor heterogeneity that may illuminate drivers of tumor invasion, we created a glioblastoma tumor cell atlas with single-cell transcriptomics of cancer cells mapped onto a reference framework of the developing and adult human brain.
Sören Müller +2 more
exaly +8 more sources
Human iPSC-Derived Cerebral Organoids Model Cellular Features of Lissencephaly and Reveal Prolonged Mitosis of Outer Radial Glia [PDF]
Cell Stem Cell, 2017 Classical lissencephaly is a genetic neurological disorder associated with mental retardation and intractable epilepsy, and Miller-Dieker syndrome (MDS) is the most severe form of the disease. In this study, to investigate the effects of MDS on human progenitor subtypes that control neuronal output and influence brain topology, we analyzed cerebral ...
Arnold Kriegstein +2 more
exaly +8 more sources
Neuronal Delamination and Outer Radial Glia Generation in Neocortical Development [PDF]
Frontiers in Cell and Developmental Biology, 2021 During neocortical development, many neuronally differentiating cells (neurons and intermediate progenitor cells) are generated at the apical/ventricular surface by the division of neural progenitor cells (apical radial glial cells, aRGs).
Ayano Kawaguchi
doaj +4 more sources
Sonic Hedgehog Signaling: A Conserved Mechanism for the Expansion of Outer Radial Glia and Intermediate Progenitor Cells and for the Growth and Folding of the Neocortex [PDF]
Neurogenesis (Austin, Tex ), 2016 The expansion of outer radial glia (oRGs, also called basal RGs) and intermediate progenitor cells (IPCs) has played a key role in the evolutionary expansion and folding of the neocortex, resulting in superior sensorimotor and cognitive abilities.
Young-Goo Han
exaly +4 more sources
Outer Radial Glia–Like Cells May Promote Glioblastoma Invasiveness [PDF]
Cancer Discovery, 2020 Abstract Outer radial glia (oRG)–like glioma stem cells (GSC) were enriched in human glioblastomas.
exaly +3 more sources
The Primate-Specific Gene TMEM14B Marks Outer Radial Glia Cells and Promotes Cortical Expansion and Folding [PDF]
Cell Stem Cell, 2017 Human brain evolution is associated with expansion and folding of the neocortex. Increased diversity in neural progenitor (NP) populations (such as basally located radial glia [RG], which reside in an enlarged outer subventricular zone [OSVZ]) likely contributes to this evolutionary expansion, although their characteristics and relative contributions ...
Lu Yang, Le Sun, Qian Wu
exaly +3 more sources