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Glioblastoma Model Using Human Cerebral Organoids [PDF]
Cell Reports, 2018 Summary: We have developed a cancer model of gliomas in human cerebral organoids that allows direct observation of tumor initiation as well as continuous microscopic observations.
Gerald M Pao +1 more
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Analysis of Synapses in Cerebral Organoids [PDF]
Cell Transplantation, 2019 Cerebral organoids are an emerging cutting-edge technology to model human brain development and neurodevelopmental disorders, for which mouse models exhibit significant limitations.
Abraam M. Yakoub, Mark Sadek
doaj +4 more sources
Modeling Patient-Derived Glioblastoma With Cerebral Organoids [PDF]
Cell Reports, 2019 The prognosis of patients with glioblastoma (GBM) remains dismal, with a median survival of approximately 15 months. Current preclinical GBM models are limited by the lack of a "normal" human microenvironment and the inability of many tumor cell lines to accurately reproduce GBM biology.
Leona Cohen-Gould +2 more
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Human Blood Vessel Organoids Penetrate Human Cerebral Organoids and Form a Vessel-Like System
Cells, 2021 Vascularization of tissues, organoids and organ-on-chip models has been attempted using endothelial cells. However, the cultured endothelial cells lack the capacity to interact with other somatic cell types, which is distinct from developing vascular ...
Bong-Seok Song, Bo-Woong Sim, Hong J Lee
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The Moral Status of Cerebral Organoids
Regenerative Therapy, 2019 Organoids are 3D biological structures constructed from stem cells in vitro. They partially mimic the function of real organs. Although the number of articles detailing this technology has increased in recent years, papers debating their ethical issues ...
Drima Eduard, Paula Perlea, Ionuț Negoi
exaly +5 more sources
Cells, 2020 Background: The development of 3D cerebral organoid technology using human-induced pluripotent stem cells (iPSCs) provides a promising platform to study how brain diseases are appropriately modeled and treated.
Xiaojie Liu +2 more
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Induction of Expansion and Folding in Human Cerebral Organoids [PDF]
Cell Stem Cell, 2017 An expansion of the cerebral neocortex is thought to be the foundation for the unique intellectual abilities of humans. It has been suggested that an increase in the proliferative potential of neural progenitors (NPs) underlies the expansion of the cortex and its convoluted appearance. Here we show that increasing NP proliferation induces expansion and
Rudolf Jaenisch, Jürgen Knoblich
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Molecular Therapy - Methods and Clinical Development, 2020 The development of gene therapies for central nervous system disorders is challenging because it is difficult to translate preclinical data from current in vitro and in vivo models to the clinic.
Pavlina Konstantinova +2 more
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Cerebral Organoids as an Experimental Platform for Human Neurogenomics
Cells, 2022 The cerebral cortex forms early in development according to a series of heritable neurodevelopmental instructions. Despite deep evolutionary conservation of the cerebral cortex and its foundational six-layered architecture, significant variations in ...
Tomasz J. Nowakowski, Sofie R. Salama
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Advances and Challenges in Cerebral Organoids Research
Advanced NanoBiomed ResearchCerebral organoids are three‐dimensional (3D) aggregates with a more advanced composition, maturation, and architecture. It has emerged as a novel and sophisticated model system for studying neurodevelopment and neurological disorders, in comparison to ...
Zhen Gu, Dandan Luo
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