Results 11 to 20 of about 472,990 (216)

The promise of cerebral organoids for neonatology [PDF]

Current Opinion in Pediatrics
Purpose of review Applying discoveries from basic research to patients in the neonatal intensive care unit (NICU) is challenging given the difficulty of modeling this population in animal models, lack of translational relevance from animal models to humans, and scarcity of primary human tissue.
Howard, Clare E, Cheenath, Manju, Crouch, Elizabeth E   +2 more
core   +5 more sources

Pax6 mutant cerebral organoids partially recapitulate phenotypes of Pax6 mutant mouse strains [PDF]

PLoS ONE, 2022
Cerebral organoids show great promise as tools to unravel the complex mechanisms by which the mammalian brain develops during embryogenesis. We generated mouse cerebral organoids harbouring constitutive or conditional mutations in Pax6, which encodes a ...
Nurfarhana Ferdaos, Sally Lowell, John O. Mason   +2 more
doaj   +4 more sources

Microglia-like Cells Promote Neuronal Functions in Cerebral Organoids [PDF]

Cells, 2021
Human cerebral organoids, derived from induced pluripotent stem cells, offer a unique in vitro research window to the development of the cerebral cortex.
Ilkka Fagerlund, Antonios Dougalis, Anastasia Shakirzyanova, Mireia Gómez-Budia, Anssi Pelkonen, Henna Konttinen, Sohvi Ohtonen, Mohammad Feroze Fazaludeen, Marja Koskuvi, Johanna Kuusisto, Damián Hernández, Alice Pebay, Jari Koistinaho, Tuomas Rauramaa, Šárka Lehtonen, Paula Korhonen, Tarja Malm   +16 more
doaj   +2 more sources

NeuroSuite for Long-Term Functional and Structural Studies of Air-Liquid Interface Cerebral Organoids. [PDF]

Adv Sci (Weinh)
NeuroSuite provides a modular hardware‐software platform integrating Neuroweb and NeuroMaps to enable long‐term, in situ electrophysiological interrogation of air–liquid interface organoid slices while preserving tissue architecture. Its components can be used together or independently to capture real‐time activity, spatial network dynamics, and ...
Haider B, Middya S, Lloyd-Davies-Sánchez DJ, Läubli NF, Vora S, Träuble J, Krajeski RN, Feng Y, Duncko D, Riley JS, Ruiz-Mateos Serrano R, Paulsen O, Lancaster MA, Malliaras GG, Kaminski Schierle GS.   +14 more
europepmc   +2 more sources

Building Immunocompetent Cerebral Organoids From a Developmental Perspective [PDF]

Glia
ABSTRACTCerebral organoids derived from human induced pluripotent stem cells (iPSCs) are increasingly becoming essential tools to study the human brain, from understanding pathological mechanisms in neurodevelopmental, neurodegenerative, and infectious diseases to identifying genetic risks and biomarkers.
Cuesta‐Puente, Xabier, Gonzalez‐Dominguez, Marco, Pereira‐Iglesias, Marta, Perez‐Arriazu, Nerea, Villegas‐Zafra, Patricia, Ramos‐Gonzalez, Paula, Cavaliere, Fabio, Bengoa‐Vergniory, Nora, Sierra, Amanda   +8 more
core   +5 more sources

Development and Characterization of Human Cerebral Organoids [PDF]

Cell Transplantation, 2018
Studies of human neurodevelopmental disorders and stem cell–based regenerative transplants have been hampered by the lack of a model of the developing human brain. Stem cell–derived neurons suffer major limitations, including the ability to recapitulate the 3-dimensional architecture of a brain tissue and the representation of multiple layers and cell ...
Yakoub, Abraam M., Sadek, Mark
openaire   +3 more sources

Small molecule compounds improve the targeted differentiation efficiency of cerebral organoids from pluripotent stem cells [PDF]

Jichu yixue yu linchuang
Objective To optimize the conditions and improve the efficiency for the differentiation of pluripotent stem cells (PSCs) into cerebral organoids. Methods Based on the induction differentiation system for inducing human embryonic stem cells (hESCs) H9 ...
ZHU Wanwan, ZHOU Jinjuan, XIU Jianbo
doaj   +2 more sources

Molecular Signatures of HIV-Induced Neuroinflammation and Neurodegeneration in Human Cerebral Organoids: Identification of Therapeutic Targets for NeuroHIV. [PDF]

Adv Sci (Weinh)
HIV preferentially infects microglia, activating IL‐17A‐driven IFN‐γ/STAT1, CEBPB, and NF‐κB signaling that converges with cGAS‐STING and Notch–NEURL1 pathways, promoting neuroinflammation, mitochondrial dysfunction, and synaptic impairment. cART suppresses viral replication, attenuates inflammatory signaling, and at least partially restores ...
Chennakesavan K, Samikkannu M, Gupta S, Tayo OI, Acharya A, Cai JJ, Byrareddy SN, Samikkannu T.   +7 more
europepmc   +2 more sources

Multiscale Comparative Analyses of OVB-Organoids and Cerebral Organoids [PDF]

Cells
Organoid technology is critical for studying human brain development, but existing single-organoid culture systems fail to simulate inter-organ interactions (e.g., optic vesicle–brain) in embryogenesis. This study aimed to establish a more comprehensive in vitro model for early neurodevelopment.
Jingyi Yang, Xue Zhang, Shuang Li, Zhixian Gao   +3 more
openaire   +3 more sources

Long-Term Survival and Maturation of Transplanted Cerebral Organoids Derived from Human Induced Pluripotent Stem Cells [PDF]

Cells
Human cerebral organoids have emerged as a promising new therapeutic strategy for cell transplantation after brain injury. Researchers have explored the short-term survival and maturation of human cerebral organoids derived from human embryonic stem ...
Xiaoli Ji, Zhongmeng Xiong, Wanxing Li
doaj   +2 more sources