Results 1 to 10 of about 459,917 (239)

Matrigel Tunes H9 Stem Cell-Derived Human Cerebral Organoid Development [PDF]

Organoids, 2023
Human cerebral organoids are readily generated from human embryonic stem cells and human induced pluripotent stem cells and are useful in studying human neurodevelopment.
Ronald Estridge, Albert J Keung
exaly   +5 more sources

A Cerebral Organoid Connectivity Apparatus to Model Neuronal Tract Circuitry [PDF]

Micromachines, 2021
Mental disorders have high prevalence, but the efficacy of existing therapeutics is limited, in part, because the pathogenic mechanisms remain enigmatic.
Jeffrey D Zahn, Andrew J Boreland, Zhiping P. Pang   +2 more
exaly   +5 more sources

The Ethics of Cerebral Organoid Research: Being Conscious of Consciousness [PDF]

Stem Cell Reports, 2019
Recently, the use of three-dimensional neural tissues cultured in vitro and called ''cerebral organoids'' has advanced recapitulation of neural development and disease modeling studies. Along with such advances, cerebral organoid research, and associated
Misao Fujita, Hideya Sakaguchi, Tsutomu Sawai   +2 more
exaly   +4 more sources

Cerebral Organoid Research Ethics and Pinning the Tail on the Donkey [PDF]

Cambridge Quarterly of Healthcare Ethics, 2023
The risk of creating cerebral organoids/assembloids conscious enough to suffer is a recurrent concern in organoid research ethics. On one hand, we should, apparently, avoid discovering how to distinguish between organoids that it would be permissible ...
Alex McKeown
exaly   +6 more sources

Human PSCs determine the competency of cerebral organoid differentiation via FGF signaling and epigenetic mechanisms [PDF]

iScience, 2022
Summary: Various culture methods have been developed for maintaining human pluripotent stem cells (PSCs). These PSC maintenance methods exhibit biased differentiation; for example, feeder-dependent PSCs efficiently yield cerebral organoids, but it is ...
Hirosato Ideno, Kent Imaizumi, Hiroko Shimada, Tsukasa Sanosaka, Akisa Nemoto, Jun Kohyama, Hideyuki Okano   +6 more
doaj   +2 more sources

Single molecule nanopore counting assay targeting small extracellular vesicle cargo for non-invasive monitoring of cerebral organoid development and health [PDF]

Scientific Reports
Organoids are three-dimensional tissue cultures intended to replicate in vivo organs such that their function can be analyzed for applications in drug discovery, diagnostics, and research. This requires the ability to assess organoid health, development,
S. M. Saiduzzaman, Ruiting Xu, Mohammad Julker Neyen Sampad, Ryan N. Hoffman, Spencer T. Seiler, Quinton Brail, Viktor Yurevych, Zachary J. Walker, Tanner N. Wells, Ephraim M. Ong, Thomas D. Yuzvinsky, Aaron R. Hawkins, Sofie R. Salama, Mircea Teodorescu, David Haussler, Holger Schmidt   +15 more
doaj   +2 more sources

Human-Induced Pluripotent Stem Cell-Derived Cerebral Organoid of Leukoencephalopathy With Vanishing White Matter [PDF]

CNS Neuroscience and Therapeutics, 2023
Ye Wu, Yuwu Jiang, Jiong Deng
exaly   +2 more sources

A Microglia-Containing Cerebral Organoid Model to Study Early Life Immune Challenges [PDF]

Brain, Behavior, and Immunity
Alice Buonfiglioli, Rebecca Chiu, Ada J Lin   +2 more
exaly   +2 more sources

Neural Responses to Hypoxic Injury in a Vascularized Cerebral Organoid Model [PDF]

Neuroscience Bulletin
Zhen G Luo
exaly   +2 more sources

Mitigating Effect of Estrogen in Alzheimer’s Disease-Mimicking Cerebral Organoid [PDF]

Frontiers in Neuroscience, 2022
Yeri Alice Rim, Juryun Kim, Ji Hyeon Ju
exaly   +2 more sources