Fundamental signaling pathways for glioblastoma drug resistance and developing robust organoid models for drug discovery [PDF]
, 2022 This article presents a review of the current literature on the molecular mechanisms of treatment resistance in glioblastoma. As mounting research continues to explore novel methods of treating glioblastoma, from using organoid models for drug screening ...
Byoung-San Moon +3 more
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Progress, prospects, and limitations of organoid technology [PDF]
, 2022 Organoids are mini-organs generated through in vitro 3-dimensional culture that mimic some of the structural and physiological functions of real organs.
Jung Kyu Choi +2 more
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Optimization of cerebral organoids: a more qualified model for Alzheimer’s disease research
Translational Neurodegeneration, 2021 Alzheimer’s disease (AD) is a neurodegenerative disease that currently cannot be cured by any drug or intervention, due to its complicated pathogenesis. Current animal and cellular models of AD are unable to meet research needs for AD.
Feng-Chen Bi +8 more
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Analysis of Synapses in Cerebral Organoids [PDF]
Cell Transplantation, 2019 Cerebral organoids are an emerging cutting-edge technology to model human brain development and neurodevelopmental disorders, for which mouse models exhibit significant limitations. In the human brain, synaptic connections define neural circuits, and synaptic deficits account for various neurodevelopmental disorders.
Abraam M. Yakoub, Mark Sadek
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Trends in the global organoid technology and industry: from organogenesis in a dish to the commercialization of organoids [PDF]
, 2021 Animal models have been standard methods for non-clinical research in drug development for decades. However, many drugs that have shown satisfactory results in non-clinical studies have failed in the clinical stage, presumably because animal data are not
Dong-Hun Woo +3 more
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Three-dimensional cardiac organoid formation accelerates the functional maturation of human induced pluripotent stem cell-derived cardiomyocytes [PDF]
, 2022 Background Human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes (CMs) offer a promising source for heart disease modeling and drug screening.
Dong-Hun Woo +7 more
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An AI-based segmentation and analysis pipeline for high-field MR monitoring of cerebral organoids
Scientific Reports, 2023 Cerebral organoids recapitulate the structure and function of the developing human brain in vitro, offering a large potential for personalized therapeutic strategies.
Luca Deininger +13 more
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A review of protocols for brain organoids and applications for disease modeling
STAR Protocols, 2023 Summary: Recent breakthroughs in human stem cell technologies have enabled the generation of 3D brain organoid platforms for modeling human neurodevelopment and disease.
Christopher N. Mayhew, Richa Singhania
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Understanding the cellular pathogenesis of COVID-19 symptoms using organoid technology [PDF]
, 2022 Patients with coronavirus disease 2019 (COVID-19), which has recently caused a pandemic, have reported symptoms of coronavirus infection that are not well understood by the medical community in general. After severe acute respiratory syndrome coronavirus
Young Hyun Che, Yong Jun Kim
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Cerebral Organoids—Challenges to Establish a Brain Prototype [PDF]
Cells, 2021 The new cellular models based on neural cells differentiated from induced pluripotent stem cells have greatly enhanced our understanding of human nervous system development. Highly efficient protocols for the differentiation of iPSCs into different types of neural cells have allowed the creation of 2D models of many neurodegenerative diseases and ...
Artem V. Eremeev +4 more
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