Results 31 to 40 of about 459,917 (239)
Toward brain organoid-based precision medicine in neurodegenerative diseases [PDF]
, 2022 In recent years, the concept of precision medicine—an approach to developing personalized drugs for disease prevention or treatment—has emerged as an up-and-coming field in medical research.
Inhee Mook-Jung, Jong-Chan Park
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TP53-PTEN-NF1 depletion in human brain organoids produces a glioma phenotype in vitro
Frontiers in Oncology, 2023 Glioblastoma (GBM) is fatal and the study of therapeutic resistance, disease progression, and drug discovery in GBM or glioma stem cells is often hindered by limited resources.
Sanjay K. Singh +15 more
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Standard operating protocol of hepatic organoid differentiation from human induced pluripotent stem cells [PDF]
, 2022 Background Mature liver organoids are potential cellular sources for research to understand the pathology of several liver-related conditions, including end-stage chronic liver disease.
Jung-Hyun Kim +4 more
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Cerebral Organoids in a Dish: Progress and Prospects [PDF]
Cell, 2013 A three-dimensional culture of cortical tissues derived from pluripotent stem cells offers an opportunity to model human brain development and disorders. In a recent issue of Nature, Lancaster et al. describe a new method for generating cerebral organoids in a dish and use it to model microcephaly.
Bershteyn, Marina, Kriegstein, Arnold R
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Therapeutic applications of three-dimensional organoid models in lung cancer [PDF]
, 2021 Lung cancer, which remains a major cause of mortality worldwide, is a histologically diverse condition and demonstrates substantial phenotypic and genomic diversity among individual patients, manifesting as both intertumoral and intratumoral ...
Yongki Hwang +9 more
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Cerebral Organoid Models for Neurotropic Viruses [PDF]
ACS Infectious Diseases, 2019 Across zoonotic pathogens, RNA viruses are responsible for disproportionate levels of human disease, suffering, and death. Neurotropic RNA viruses (e.g., rabies, Japanese and Eastern Equine Encephalitis, Ebola, West Nile, Powassan) infect the brain and spinal cord, causing meningitis, encephalitis, microcephaly, and Guillain-Barré syndrome. Mechanistic
Antonucci, Jenna, Gehrke, Lee
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Multiscale 3D phenotyping of human cerebral organoids [PDF]
Scientific Reports, 2020 Abstract Brain organoids grown from human pluripotent stem cells self-organize into cytoarchitectures resembling the developing human brain. These three-dimensional models offer an unprecedented opportunity to study human brain development and dysfunction.
Albanese, Alexandre +9 more
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Cells, 2020 Background: The development of 3D cerebral organoid technology using human-induced pluripotent stem cells (iPSCs) provides a promising platform to study how brain diseases are appropriately modeled and treated.
Sarah Logan +7 more
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Silk scaffolding drives self-assembly of functional and mature human brain organoids
Frontiers in Cell and Developmental Biology, 2022 Human pluripotent stem cells (hPSCs) are intrinsically able to self-organize into cerebral organoids that mimic features of developing human brain tissue.
Edoardo Sozzi +10 more
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Comparative Multiomics Analysis of Cerebral Organoid-Derived Exosomes during Organoid Maturation. [PDF]
Nano LettCerebral organoids derived from human pluripotent stem cells recapitulate key features of early brain development and provide a physiologically relevant model for neurogenesis. Exosomes secreted by these organoids carry bioactive cargo and offer a noninvasive means to monitor maturation and intercellular communication.
Kim YE +15 more
europepmc +3 more sources