Results 51 to 60 of about 459,917 (239)

Alveolar organoids: development of an assay to facilitate pulmonary toxicity assessments [PDF]

, 2022
Background Animal experiments have been performed to predict toxicity in humans in many fields, in-cluding toxicology, medicine, and pharmacology, and have contributed to increasing life ex-pectancy. However, animal testing has been a controversial issue
Seok-Ho Hong, Seung-Jun Wang, Ji Young Lee, Se-Ran Yang, Jooyeon Lee, Hyosin Baek, Jong-Hee Lee, Myung Ha Song   +7 more
core   +1 more source

Clinical applications and optimization of patient-derived organoids in intestinal diseases [PDF]

, 2022
Since the first successful establishment of organoids from adult intestinal stem cells, organoid technology has rapidly developed. With advances in normal organoid technology, intestinal disorders, such as colorectal tumors and inflammatory bowel disease,
Tae Il Kim
core   +1 more source

Forebrain Organoids to Model the Cell Biology of Basal Radial Glia in Neurodevelopmental Disorders and Brain Evolution

Frontiers in Cell and Developmental Biology, 2022
The acquisition of higher intellectual abilities that distinguish humans from their closest relatives correlates greatly with the expansion of the cerebral cortex.
Flaminia Kaluthantrige Don, Nereo Kalebic   +1 more
doaj   +1 more source

Modeling human brain development with cerebral organoids [PDF]

Stem Cell Research & Therapy, 2013
The recent discovery of a new three-dimensional culture system for the derivation of cerebral organoids from human induced pluripotent stem cells provides developmental neurobiologists with the first example of a three-dimensional framework for the study of human brain development.
Muzio L, CONSALEZ , GIAN GIACOMO
openaire   +3 more sources

Brain organoid formation on decellularized porcine brain ECM hydrogels.

PLoS ONE, 2021
Human brain tissue models such as cerebral organoids are essential tools for developmental and biomedical research. Current methods to generate cerebral organoids often utilize Matrigel as an external scaffold to provide structure and biologically ...
Robin Simsa, Theresa Rothenbücher, Hakan Gürbüz, Nidal Ghosheh, Jenny Emneus, Lachmi Jenndahl, David L Kaplan, Niklas Bergh, Alberto Martinez Serrano, Per Fogelstrand   +9 more
doaj   +1 more source

Public perceptions and expectations: Disentangling the hope and hype of organoid research [PDF]

, 2023
Organoid technologies are rapidly advancing and hold great potential and hope for disease modeling and clinical translational research. Still, they raise a number of complex, ethical questions regarding their current and future use.
Pegoraro, Renzo, Sørensen, Mads P, Picozzi, Mario, Kavouras, Panagiotis, Capulli, Emma, Saugstrup, Louise I., Ravn, Tine, Spyrakou, Eleni, Sørensen, Mads P., Saugstrup, Louise I, Stavridi, Vana, Mario Picozzi, Emma Capulli, Renzo Pegoraro, Eleni Spyrakou, Mads P. Sørensen, Tine Ravn, Panagiotis Kavouras, Vana Stavridi, Louise I. Saugstrup   +19 more
core   +1 more source

The promise of cerebral organoids for neonatology

Current Opinion in Pediatrics
Purpose of review Applying discoveries from basic research to patients in the neonatal intensive care unit (NICU) is challenging given the difficulty of modeling this population in animal models, lack of translational relevance from animal models to humans, and scarcity of primary human tissue.
Howard, Clare E, Cheenath, Manju, Crouch, Elizabeth E   +2 more
openaire   +3 more sources

Microengineered organoids: reconstituting organ-level functions in vitro [PDF]

, 2023
In vitro miniaturized organoids are innovative tools with varying applications in biomedical engineering, such as drug testing, disease modeling, organ development studies, and regenerative medicine. However, conventional organoid development has several
Harshita Sharma, Sunho Park, Woochan Kim, Yonghyun Gwon, Hyoseong Kim, Jangho Kim, Yun-Hoon Choung   +6 more
core   +1 more source

Induction of Expansion and Folding in Human Cerebral Organoids [PDF]

Cell Stem Cell, 2017
An expansion of the cerebral neocortex is thought to be the foundation for the unique intellectual abilities of humans. It has been suggested that an increase in the proliferative potential of neural progenitors (NPs) underlies the expansion of the cortex and its convoluted appearance. Here we show that increasing NP proliferation induces expansion and
Li Y, Muffat J, Omer A, Bosch I, Lancaster MA, Sur M, Gehrke L, Knoblich JA, Jaenisch R.   +8 more
openaire   +2 more sources

Human cerebral organoids as a new legal and ethical challenge† [PDF]

Journal of Law and the Biosciences, 2020
ABSTRACT Human cerebral organoids (HCOs) are miniature brains cultivated in a dish using pluripotent human cells that, thanks to advanced technologies, tend to reproduce the development path of the brain of an embryo in the mother’s uterus.
Lavazza, Andrea, Pizzetti, Federico Gustavo   +1 more
openaire   +3 more sources