Results 61 to 70 of about 459,917 (239)

Disease modeling and drug screening using human airway organoids: a systematic review [PDF]

, 2021
Increasing levels of fine environmental dust particles due to industrialization and emerging respiratory illnesses, such as coronavirus disease 2019, pose serious threats to human life.
Sung Won Kim, Do Hyun Kim
core   +1 more source

Human cerebral organoids: the ethical stance of scientists

Stem Cell Research & Therapy, 2023
Abstract Background Human cerebral organoids (HCOs) offer unprecedented opportunities to study the human brain in vitro , but they also raise important ethical concerns. Here we report the first systematic analysis of scientists’
Andrea Lavazza, Alice Andrea Chinaia
openaire   +3 more sources

Knowledge graphs of ethical concerns of cerebral organoids

Cell Proliferation, 2022
AbstractObjectivesThe rapid development of cerebral organoid technology and the gradual maturity of cerebral organoids highlight the necessity of foresighted research on relevant ethical concerns. We employed knowledge graphs and conducted statistical analysis with CiteSpace for a comprehensive analysis of the status quo of the research on the ethical ...
Lulu Ding, Zhenyu Xiao, Xia Gong, Yaojin Peng   +3 more
openaire   +2 more sources

Gene Expression Profiles of Human Cerebral Organoids Identify PPAR Pathway and PKM2 as Key Markers for Oxygen-Glucose Deprivation and Reoxygenation

Frontiers in Cellular Neuroscience, 2021
Ischemic stroke is one of the most common neurological diseases. However, the impact of ischemic stroke on human cerebral tissue remains largely unknown due to a lack of ischemic human brain samples.
Naoki Iwasa, Takeshi K. Matsui, Takeshi K. Matsui, Naohiko Iguchi, Kaoru Kinugawa, Naritaka Morikawa, Yoshihiko M. Sakaguchi, Tomo Shiota, Shinko Kobashigawa, Mari Nakanishi, Masaya Matsubayashi, Riko Nagata, Sotaro Kikuchi, Tatsuhide Tanaka, Nobuyuki Eura, Takao Kiriyama, Tesseki Izumi, Kozue Saito, Hiroshi Kataoka, Yuichi Saito, Wataru Kimura, Akio Wanaka, Yuhei Nishimura, Eiichiro Mori, Eiichiro Mori, Kazuma Sugie   +25 more
doaj   +1 more source

Cerebral organoids: ethical issues and consciousness assessment [PDF]

Journal of Medical Ethics, 2018
Organoids are three-dimensional biological structures grown in vitro from different kinds of stem cells that self-organise mimicking real organs with organ-specific cell types. Recently, researchers have managed to produce human organoids which have structural and functional properties very similar to those of different organs, such as the retina, the ...
Lavazza, Andrea, Massimini, Marcello
openaire   +3 more sources

An Easy-to-Use Arrayed Brain–Heart Chip

Biosensors
Multi-organ chips are effective at emulating human tissue and organ functions and at replicating the interactions among tissues and organs. An arrayed brain–heart chip was introduced whose configuration comprises open culture chambers and closed ...
Xiyao Peng, Lei Wu, Qiushi Li, Yuqing Ge, Tiegang Xu, Jianlong Zhao   +5 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Generation of Human Blood Vessel and Vascularized Cerebral Organoids

Bio-Protocol, 2023
Brain organoids have been widely used to study diseases and the development of the nervous system. Many reports have investigated the application of brain organoids, but most of these models lack vascular structures, which play essential roles in brain ...
Xin Sun, Xiang Ju, Hong Zhao, Zhi You, Run Han, Zhen Luo   +5 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source