Results 41 to 50 of about 459,917 (239)
The moral status of cerebral organoids
Regenerative Therapy, 2019 Organoids are 3D biological structures constructed from stem cells in vitro. They partially mimic the function of real organs. Although the number of articles detailing this technology has increased in recent years, papers debating their ethical issues are few.
Sorin Hostiuc +5 more
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Cerebral organoids as a model for glioblastoma multiforme
Current Opinion in Biomedical Engineering, 2020 Glioblastoma multiforme (GBM) is a highly lethal and elusive cancer. While many in vitro and in vivo models have been developed to recapitulate the factors that contribute to its invasive behavior, they suffer from drawbacks related to genetic variability, expense and scope. Technologies utilizing human pluripotent stem cells can now generate organoids
Nathaniel Silvia, Guohao Dai
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Cultures and cures: neurodiversity and brain organoids
BMC Medical Ethics, 2021 Background Research with cerebral organoids is beginning to make significant progress in understanding the etiology of autism spectrum disorder (ASD). Brain organoid models can be grown from the cells of donors with ASD.
Andrew J. Barnhart, Kris Dierickx
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Human brain organoids in Alzheimer’s disease [PDF]
, 2021 Alzheimer’s disease (AD) is a progressive neurological disorder that typically involves neuronal damage leading to the deterioration of cognitive and essential body functions in aging brains.
Hansang Cho, You Jung Kang
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Cuaderno técnico. Defensa de derechos de las personas con daño cerebral y sus familias [PDF]
, 2022 Las personas con daño cerebral y sus familias en ocasiones ven vulnerados sus derechos ante la falta de información sociosanitaria y ante la existencia limitada de recursos especializados en el ámbito educativo, sanitario o laboral; entre otros.
Federación Española de Daño Cerebral
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Estados alterados de la conciencia tras un daño cerebral [PDF]
, 2021 Las personas somos conscientes de nosotras mismas y de nuestro entorno a través de la conciencia. No obstante, los estados alterados de la conciencia son situaciones como el coma u otros estados clínicos en los que personas con un daño cerebral severo no
Federación Española de Daño Cerebral
core
Harnessing cerebral organoids for Alzheimer's disease research
Current Opinion in Neurobiology, 2022 Alzheimer's disease (AD) is a devastating neurodegenerative disorder affecting the aging population. Despite many studies, there remains an urgent need to identify the root causes of AD, together with potential treatments. Cerebral organoid technology has made it possible to model human neurophysiology and disease with increasing accuracy in patient ...
Bubnys, Adele, Tsai, Li-Huei
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Cell Reports, 2017 Summary: The human cerebral cortex possesses distinct structural and functional features that are not found in the lower species traditionally used to model brain development and disease.
Momoko Watanabe +22 more
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Development and Characterization of Human Cerebral Organoids [PDF]
Cell Transplantation, 2018 Studies of human neurodevelopmental disorders and stem cell–based regenerative transplants have been hampered by the lack of a model of the developing human brain. Stem cell–derived neurons suffer major limitations, including the ability to recapitulate the 3-dimensional architecture of a brain tissue and the representation of multiple layers and cell ...
Yakoub, Abraam M., Sadek, Mark
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Cerebral Organoids as an Experimental Platform for Human Neurogenomics
Cells, 2022 The cerebral cortex forms early in development according to a series of heritable neurodevelopmental instructions. Despite deep evolutionary conservation of the cerebral cortex and its foundational six-layered architecture, significant variations in cortical size and folding can be found across mammals, including a disproportionate expansion of the ...
Tomasz J. Nowakowski, Sofie R. Salama
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