Results 11 to 20 of about 459,917 (239)
Glioblastoma Model Using Human Cerebral Organoids [PDF]
Cell Reports, 2018 Summary: We have developed a cancer model of gliomas in human cerebral organoids that allows direct observation of tumor initiation as well as continuous microscopic observations.
Junko Ogawa +3 more
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Microglia innately develop within cerebral organoids [PDF]
Nature Communications, 2018 Brain organoid models reported to date lack cells of mesodermal origin, such as microglia. Here, the authors demonstrate that mature microglia-like cells are generated within their cerebral organoid model, providing new avenues for studying human ...
Paul R. Ormel +17 more
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Modeling Patient-Derived Glioblastoma with Cerebral Organoids [PDF]
Cell Reports, 2019 Summary: The prognosis of patients with glioblastoma (GBM) remains dismal, with a median survival of approximately 15 months. Current preclinical GBM models are limited by the lack of a “normal” human microenvironment and the inability of many tumor cell
Amanda Linkous +19 more
doaj +4 more sources
PLoS ONE, 2021 Cerebral organoids generated from human pluripotent stem cells (hiPSCs) are unique in their ability to recapitulate human-specific neurodevelopmental events.
Chloe Delepine +3 more
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Three-Dimensional Organoid System Transplantation Technologies in Future Treatment of Central Nervous System Diseases [PDF]
Stem Cells International, 2017 In recent years, scientists have made great achievements in understanding the development of human brain and elucidating critical elements of stepwise spatiotemporal control strategies in neural stem cell specification lineage, which facilitates ...
NaiLi Wei +3 more
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An Ethical Analysis of Human Cerebral Organoids
Yixue yu zhexueHuman cerebral organoids are three-dimensional neural tissues with similar structure and biological function to human brain. Human cerebral organoids can be used to study human brain development, disease mechanisms, and drug screening.
Bin HUANG
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Single Cerebral Organoid Mass Spectrometry of Cell-Specific Protein and Glycosphingolipid Traits. [PDF]
Anal Chem, 2023 Cerebral organoids are a prolific research topic and an emerging model system for neurological diseases in human neurobiology. However, the batch-to-batch reproducibility of current cultivation protocols is challenging and thus requires a high-throughput
Nezvedová M +8 more
europepmc +2 more sources
Glioblastoma organoid technology: an emerging preclinical models for drug discovery [PDF]
, 2022 Glioblastoma multiforme (GBM) is the most prevalent type of primary brain tumor among adults, and it has a median overall survival of 12 to 15 months upon diagnosis.
Shuchang Zhou +3 more
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Lineage recording in human cerebral organoids [PDF]
Nature Methods, 2021 Abstract Induced pluripotent stem cell (iPSC)-derived organoids provide models to study human organ development. Single-cell transcriptomics enable highly resolved descriptions of cell states within these systems; however, approaches are needed to directly measure lineage relationships.
Zhisong He +14 more
openaire +5 more sources
Recent advances and challenges in organoid-on-a-chip technology [PDF]
, 2022 Conventional 2-dimensional cell culture poorly mimics human-relevant models, which is considered a major challenge in biological research. Organoids are a recent breakthrough in 3-dimensional (3D) in vitro tissue engineering that better reflect the ...
Tae-Hyung Kim, Intan Rosalina Suhito
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