Results 21 to 30 of about 472,990 (216)
Modeling human brain development with cerebral organoids [PDF]
Stem Cell Research & Therapy, 2013 The recent discovery of a new three-dimensional culture system for the derivation of cerebral organoids from human induced pluripotent stem cells provides developmental neurobiologists with the first example of a three-dimensional framework for the study of human brain development.
Muzio L, CONSALEZ , GIAN GIACOMO
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Applications of multiphoton microscopy in imaging cerebral and retinal organoids [PDF]
Frontiers in NeuroscienceCerebral organoids, self-organizing structures with increased cellular diversity and longevity, have addressed shortcomings in mimicking human brain complexity and architecture.
Macit Emre Lacin, Murat Yildirim
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Multiscale 3D phenotyping of human cerebral organoids [PDF]
Scientific Reports, 2020 Abstract Brain organoids grown from human pluripotent stem cells self-organize into cytoarchitectures resembling the developing human brain. These three-dimensional models offer an unprecedented opportunity to study human brain development and dysfunction.
Albanese, Alexandre +9 more
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Cerebral Organoids in a Dish: Progress and Prospects [PDF]
Cell, 2013 A three-dimensional culture of cortical tissues derived from pluripotent stem cells offers an opportunity to model human brain development and disorders. In a recent issue of Nature, Lancaster et al. describe a new method for generating cerebral organoids in a dish and use it to model microcephaly.
Bershteyn, Marina, Kriegstein, Arnold R
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Multiscale Analysis of Cellular Composition and Morphology in Intact Cerebral Organoids
Biology, 2022 Cerebral organoids recapitulate in vivo phenotypes and physiological functions of the brain and have great potential in studying brain development, modeling diseases, and conducting neural network research.
Haihua Ma +7 more
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Protocol for the establishment and morphological characterization of long-term cultivated murine cerebral organoids [PDF]
STAR ProtocolsSummary: Murine cerebral organoids provide a rapid and reproducible in vitro system that recapitulates key aspects of neurogenesis. While human cerebral organoid protocols are well established, methods for non-human models remain limited.
Issam El-Debs +4 more
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Cerebral organoids as tools to identify the developmental roots of autism [PDF]
Molecular Autism, 2020 Some autism spectrum disorders (ASD) likely arise as a result of abnormalities during early embryonic development of the brain. Studying human embryonic brain development directly is challenging, mainly due to ethical and practical constraints.
Wai Kit Chan +3 more
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Microglia innately develop within cerebral organoids [PDF]
Nature Communications, 2018 Abstract Cerebral organoids are 3D stem cell-derived models that can be utilized to study the human brain. The current consensus is that cerebral organoids consist of cells derived from the neuroectodermal lineage. This limits their value and applicability, as mesodermal-derived microglia are important players in neural development ...
Paul R. Ormel +17 more
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Regulating Possibly Sentient Human Cerebral Organoids [PDF]
AJOB Neuroscience, 2023 Due to their contested ethical and legal status, human cerebral organoids (HCOs) have become the subject of one of the most rapidly expanding debates in the recent bioethics literature.
Heather Browning, Walter Veit
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Sporadic Creutzfeldt-Jakob disease prion infection of human cerebral organoids [PDF]
Acta Neuropathologica Communications, 2019 For the transmissible, neurogenerative family of prion diseases, few human models of infection exist and none represent structured neuronal tissue. Human cerebral organoids are self-organizing, three-dimensional brain tissues that can be grown from ...
Bradley R. Groveman +6 more
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