Results 31 to 40 of about 472,990 (216)

Cerebral Organoids and Antisense Oligonucleotide Therapeutics: Challenges and Opportunities [PDF]

Frontiers in Molecular Neuroscience, 2022
The advent of stem cell-derived cerebral organoids has already advanced our understanding of disease mechanisms in neurological diseases. Despite this, many remain without effective treatments, resulting in significant personal and societal health burden.
Jenny Lange, Haiyan Zhou, Haiyan Zhou, Amy McTague, Amy McTague   +4 more
doaj   +3 more sources

Polygenic risk score of Alzheimer's disease is associated with cognitive trajectories and phenotypes of cerebral organoids [PDF]

Alzheimers Dement
INTRODUCTION: Polygenic risk score (PRS) identifies individuals at high genetic risk for Alzheimer's disease (AD), but its utility in predicting cognitive trajectories and AD pathologies remains unclear. We optimized PRS (optPRS) for AD, investigated its
Choi, Y, Won, HH, Hong, CH, Jung, SH, Kim, B, Na, DL, Son, SJ, Cho, M, Lee, SY, Kim, HJ, Jang, H, Choi, SH, Jeong, JH, Roh, HW, Kim, HR, Son, HJ, Seo, SW, Seo, J, Chun, MY, Choe, J   +19 more
core   +2 more sources

An Ethical Analysis of Human Cerebral Organoids

Yixue yu zhexue
Human cerebral organoids are three-dimensional neural tissues with similar structure and biological function to human brain. Human cerebral organoids can be used to study human brain development, disease mechanisms, and drug screening.
Bin HUANG
doaj   +2 more sources

Requirements for Human Cerebral Organoids [PDF]

Cell Proliferation
Ya‐Jie Xu, Chun‐Hui Duan, Tie‐Shan Tang, Yu‐Kai Wang, Weihong Song, Bo‐Qiang Fu, Ai‐Jin Ma, Bao‐Yang Hu, Zhen‐Ge Luo, Xiao‐Qing Zhang, Yan Liu, Zhao‐Qian Teng, Jie Hao, Qiang Wei, Zhi‐Hong Wu, Yong Zhang, Bing Zhao, Shan Bian, Jing‐Zhong Zhang, Bo Peng, Tian‐Qing Li, Yue‐Jun Chen, Jing Liu, Lei Wang, Yang Zhao, Wei‐Qi Zhang, Yao‐Jin Peng, Bo‐Ya Zhang, Xin‐Jie Bao, Yan‐Lin Wang, Yi Tang, Shi‐Jun Hu, Qian Li, Gao‐Xiang Zhu, Alex Zhang, Lijun Zhu, Qi‐Yuan Li, Tao Na, Lin Zhao, Yi‐Fang Ping, Hong‐Ling Zhao, Shuai‐Shuai Niu, Qi Zhou, Tong‐Biao Zhao, Chang‐Mei Liu   +44 more
openaire   +3 more sources

Non-Invasive and Long-Term Electrophysiological Monitoring Sensors for Cerebral Organoids Differentiation [PDF]

Biosensors
Cerebral organoids derived from human induced pluripotent stem cells (iPSCs) have emerged as powerful in vitro models for studying human brain development and neurological disorders. Understanding the electrophysiological properties of these organoids is
Yan Jin, Yixun Guo, Qiushi Li, Lei Wu, Yuqing Ge, Jianlong Zhao   +5 more
doaj   +2 more sources

Human cytomegalovirus (CMV) dysregulates neurodevelopmental pathways in cerebral organoids [PDF]

Communications Biology
Human cytomegalovirus (CMV) infection is the leading non-genetic aetiology of congenital malformation in developed countries, causing significant fetal neurological injury.
Ece Egilmezer, Stuart T. Hamilton, Charles S. P. Foster, Manfred Marschall, William D. Rawlinson   +4 more
doaj   +2 more sources

Characterization of extracellular vesicles and miRNA released by cerebral organoids [PDF]

Current Research in Toxicology
Environmental toxicants can contribute to the development of several neurodegenerative diseases. However, the mechanisms behind this pathology are still incompletely understood. Prompt diagnosis of impending neurodegeneration is crucial for early interventions to prevent cognitive decline.
Brian B. Silver, Rick Fannin, Kevin Gerrish, Erik J. Tokar   +3 more
openaire   +4 more sources

Lineage recording in human cerebral organoids [PDF]

Nature Methods, 2021
Abstract Induced pluripotent stem cell (iPSC)-derived organoids provide models to study human organ development. Single-cell transcriptomics enable highly resolved descriptions of cell states within these systems; however, approaches are needed to directly measure lineage relationships.
Zhisong He, Ashley Maynard, Akanksha Jain, Tobias Gerber, Rebecca Petri, Hsiu-Chuan Lin, Malgorzata Santel, Kevin Ly, Jean-Samuel Dupré, Leila Sidow, Fatima Sanchis Calleja, Sophie M. J. Jansen, Stephan Riesenberg, J. Gray Camp, Barbara Treutlein   +14 more
openaire   +5 more sources

Microglia-like cells promote neuronal functions in cerebral organoids

, 2022
Human cerebral organoids, derived from induced pluripotent stem cells, offer a unique in vitro research window to the development of the cerebral cortex.
I Fagerlund (13377558), Š Lehtonen (11216805), P Korhonen (13377588), A Shakirzyanova (13377564), T Malm (13377591), M Koskuvi (11216772), Damian Hernandez (13066917), S Ohtonen (13377576), MF Fazaludeen (15839723), A Pebay (13377582), A Dougalis (13377561), H Konttinen (13377573), M Gómez-Budia (13377567), A Pelkonen (13377570), J Koistinaho (11216808), J Kuusisto (7684553), T Rauramaa (13377585)   +16 more
core   +2 more sources

Generation of human induced pluripotent stem cell-derived cerebral organoids for cellular and molecular characterization [PDF]

, 2022
Human induced pluripotent stem cell (hiPSC)-derived cerebral organoids (COs) can serve as ...
Wilson, Anna F, Gutmann, David H, Wegscheid, Michelle L, David H. Gutmann, Anna F. Wilson, Alexander S. Chen, Michelle L. Wegscheid, Corina Anastasaki, Chen, Alexander S, Anastasaki, Corina   +9 more
core   +1 more source