Results 41 to 50 of about 472,990 (216)
Scientific Reports, 2021 The gene KCNJ11 encodes Kir6.2 a major subunit of the ATP-sensitive potassium channel (KATP) expressed in both the pancreas and brain. Heterozygous gain of function mutations in KCNJ11 can cause neonatal diabetes mellitus (NDM).
Gokhan Dalgin +6 more
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Cerebral Organoids—Challenges to Establish a Brain Prototype [PDF]
Cells, 2021 The new cellular models based on neural cells differentiated from induced pluripotent stem cells have greatly enhanced our understanding of human nervous system development. Highly efficient protocols for the differentiation of iPSCs into different types of neural cells have allowed the creation of 2D models of many neurodegenerative diseases and ...
Artem V. Eremeev +4 more
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eLife, 2022 Human cerebral organoids are unique in their development of progenitor-rich zones akin to ventricular zones from which neuronal progenitors differentiate and migrate radially.
Murat Yildirim +10 more
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Inferring and perturbing cell fate regulomes in human cerebral organoids
, 2021 Supplementary data for the manuscript: Inferring and perturbing cell fate regulomes in human cerebral ...
Jonas Simon Fleck +8 more
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Cerebral Organoid Models for Neurotropic Viruses [PDF]
ACS Infectious Diseases, 2019 Across zoonotic pathogens, RNA viruses are responsible for disproportionate levels of human disease, suffering, and death. Neurotropic RNA viruses (e.g., rabies, Japanese and Eastern Equine Encephalitis, Ebola, West Nile, Powassan) infect the brain and spinal cord, causing meningitis, encephalitis, microcephaly, and Guillain-Barré syndrome. Mechanistic
Antonucci, Jenna, Gehrke, Lee
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Critical growth of cerebral tissue in organoids: theory and experiments [PDF]
, 2023 We develop a Fokker-Planck theory of tissue growth with three types of cells (symmetrically dividing, asymmetrically dividing and non-dividing) as main agents to study the growth dynamics of human cerebral organoids. Fitting the theory to lineage tracing
Kiselev, Egor I. +2 more
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Cerebral organoids as a model for glioblastoma multiforme
Current Opinion in Biomedical Engineering, 2020 Glioblastoma multiforme (GBM) is a highly lethal and elusive cancer. While many in vitro and in vivo models have been developed to recapitulate the factors that contribute to its invasive behavior, they suffer from drawbacks related to genetic variability, expense and scope. Technologies utilizing human pluripotent stem cells can now generate organoids
Nathaniel Silvia, Guohao Dai
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The Ethics of Cerebral Organoid Research: Being Conscious of Consciousness
Stem Cell Reports, 2019 Recently, the use of three-dimensional neural tissues cultured in vitro and called ''cerebral organoids'' has advanced recapitulation of neural development and disease modeling studies. Along with such advances, cerebral organoid research, and associated
Tsutomu Sawai +4 more
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Suspension-cultured taste bud organoids recapitulate in vivo taste buds [PDF]
, 2023 Background Taste buds are a complex organ and require a plethora of growth factors for their development, homeostasis, and regeneration. Taste bud organoids provide a platform for understanding their development, disease and regeneration. Methods In this
정한성, 이종민
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Cerebral organoid research for pediatric patients with neurological disorders [PDF]
Clinical and Experimental PediatricsCerebral organoids derived from human induced pluripotent stem cells offer a groundbreaking foundation for the analysis of pediatric neurological diseases. Unlike organoids from other somatic systems, cerebral organoids present unique challenges, such as
Jin Eun, Jung Eun Lee, Seung Ho Yang
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