Results 51 to 60 of about 472,990 (216)

TP53-PTEN-NF1 depletion in human brain organoids produces a glioma phenotype in vitro

Frontiers in Oncology, 2023
Glioblastoma (GBM) is fatal and the study of therapeutic resistance, disease progression, and drug discovery in GBM or glioma stem cells is often hindered by limited resources.
Sanjay K. Singh, Yan Wang, Ahmed Habib, Mamindla Priyadarshini, Chowdari V. Kodavali, Apeng Chen, Wencai Ma, Jing Wang, N. U. Farrukh Hameed, Baoli Hu, Gregory N. Fuller, Scott M. Kulich, Nduka Amankulor, Rivka R. Colen, Lincoln A. Edwards, Pascal O. Zinn   +15 more
doaj   +1 more source

Transcriptome analysis and functional characterization of cerebral organoids in bipolar disorder

Genome Medicine, 2020
Background Reprogramming human induced pluripotent stem cells (iPSCs) from somatic cells and generating three-dimensional brain organoids from these iPSCs provide access to live human neuronal tissue with disease-specific genetic backgrounds.
Annie Kathuria, Kara Lopez-Lengowski, Magdalena Vater, Donna McPhie, Bruce M. Cohen, Rakesh Karmacharya   +5 more
doaj   +1 more source

APOE deficiency impacts neural differentiation and cholesterol biosynthesis in human iPSC-derived cerebral organoids

Stem Cell Research & Therapy, 2023
Background The apolipoprotein E (APOE) gene is the strongest genetic risk factor for Alzheimer’s disease (AD); however, how it modulates brain homeostasis is not clear.
Jing Zhao, Tadafumi C. Ikezu, Wenyan Lu, Jesse R. Macyczko, Yonghe Li, Laura J. Lewis-Tuffin, Yuka A. Martens, Yingxue Ren, Yiyang Zhu, Yan W. Asmann, Nilüfer Ertekin-Taner, Takahisa Kanekiyo, Guojun Bu   +12 more
doaj   +1 more source

Harnessing cerebral organoids for Alzheimer's disease research

Current Opinion in Neurobiology, 2022
Alzheimer's disease (AD) is a devastating neurodegenerative disorder affecting the aging population. Despite many studies, there remains an urgent need to identify the root causes of AD, together with potential treatments. Cerebral organoid technology has made it possible to model human neurophysiology and disease with increasing accuracy in patient ...
Bubnys, Adele, Tsai, Li-Huei
openaire   +3 more sources

Cerebral organoids exhibit mature neurons and astrocytes and recapitulate electrophysiological activity of the human brain

Neural Regeneration Research, 2019
Multiple protocols have been devised to generate cerebral organoids that recapitulate features of the developing human brain, including the presence of a large, multi-layered, cortical-like neuronal zone.
Abraam M Yakoub
doaj   +1 more source

Optimized protocol for analysis of neural stem proliferation in human-pluripotent-stem-cell-derived cerebral organoids

STAR Protocols, 2023
Summary: Cerebral organoids represent an optimal experimental system for studying human cortical development, evolution, physiology, function, and disease mechanisms.
Xiao-Yan Tang, Da Wang, Xin-Yue Zhang, Min Xu, Yan Liu   +4 more
doaj   +1 more source

APOE4 exacerbates synapse loss and neurodegeneration in Alzheimer’s disease patient iPSC-derived cerebral organoids

, 2020
APOE4 is the strongest genetic risk factor associated with late-onset Alzheimer’s disease (AD). To address the underlying mechanism, we develop cerebral organoid models using induced pluripotent stem cells (iPSCs) with APOE ε3/ε3 or ε4/ε4 genotype from ...
Fu, Yuan, Younkin, Steven G., Yamazaki, Yu, Lu, Wenyan, Ertekin-Taner, Nilüfer, Shue, Francis, Graff-Radford, Neill R., Davis, Mary D., Wang, Xue, Kanekiyo, Takahisa, Bu, Guojun, Wszolek, Zbigniew K., Zhao, Jing, Liu, Chia Chen, Chen, Kai, Job, Lucy, Brafman, David A., Martens, Yuka A., Asmann, Yan W., Jia, Lin, Ren, Yingxue, Cherukuri, Yesesri, Nguyen, Thanh Thanh   +22 more
core   +1 more source

Integrative single-cell RNA-seq analysis of vascularized cerebral organoids

BMC Biology, 2023
Background Cerebral organoids are three-dimensional in vitro cultured brains that mimic the function and structure of the human brain. One of the major challenges for cerebral organoids is the lack of functional vasculature.
Yuya Sato, Toru Asahi, Kosuke Kataoka
doaj   +1 more source

Cuaderno técnico. Defensa de derechos de las personas con daño cerebral y sus familias [PDF]

, 2022
Las personas con daño cerebral y sus familias en ocasiones ven vulnerados sus derechos ante la falta de información sociosanitaria y ante la existencia limitada de recursos especializados en el ámbito educativo, sanitario o laboral; entre otros.
Federación Española de Daño Cerebral
core  

Human PSCs determine the competency of cerebral organoid differentiation via FGF signaling and epigenetic mechanisms

iScience, 2022
Summary: Various culture methods have been developed for maintaining human pluripotent stem cells (PSCs). These PSC maintenance methods exhibit biased differentiation; for example, feeder-dependent PSCs efficiently yield cerebral organoids, but it is ...
Hirosato Ideno, Kent Imaizumi, Hiroko Shimada, Tsukasa Sanosaka, Akisa Nemoto, Jun Kohyama, Hideyuki Okano   +6 more
doaj   +1 more source