Results 61 to 70 of about 472,990 (216)

Estados alterados de la conciencia tras un daño cerebral [PDF]

, 2021
Las personas somos conscientes de nosotras mismas y de nuestro entorno a través de la conciencia. No obstante, los estados alterados de la conciencia son situaciones como el coma u otros estados clínicos en los que personas con un daño cerebral severo no
Federación Española de Daño Cerebral
core  

3D organotypic cell structures for drug development and Microorganism-Host interaction research [PDF]

Research Results in Pharmacology, 2021
Introduction: The article describes a new method of tissue engineering, which is based on the use of three-dimensional multicellular constructs consisting of stem cells that mimic the native tissue in vivo – organoids.
Ekaterina V. Zubareva, Sergey V. Nadezhdin, Natalia A. Nadezhdina, Veronika S. Belyaeva, Yuriy E. Burda, Tatyana V. Avtina, Oleg S. Gudyrev, Inga M. Kolesnik, Svetlana Yu. Kulikova, Mikhail O. Mishenin   +9 more
doaj   +3 more sources

Recent Trends and Perspectives in Cerebral Organoids Imaging and Analysis

Frontiers in Neuroscience, 2021
Purpose: Since their first generation in 2013, the use of cerebral organoids has spread exponentially. Today, the amount of generated data is becoming challenging to analyze manually. This review aims to overview the current image acquisition methods and
Clara Brémond Martin, Clara Brémond Martin, Camille Simon Chane, Cédric Clouchoux, Aymeric Histace   +4 more
doaj   +1 more source

Treating Hyperexcitability in Human Cerebral Organoids Resulting from Oxygen-Glucose Deprivation

Cells, 2023
Human cerebral organoids resemble the 3D complexity of the human brain and have the potential to augment current drug development pipelines for neurological disease. Epilepsy is a complex neurological condition characterized by recurrent seizures.
Alexandra C. Santos, George Nader, Dana El Soufi El Sabbagh, Karolina Urban, Liliana Attisano, Peter L. Carlen   +5 more
doaj   +1 more source

Human cerebral organoids as a new legal and ethical challenge† [PDF]

Journal of Law and the Biosciences, 2020
ABSTRACT Human cerebral organoids (HCOs) are miniature brains cultivated in a dish using pluripotent human cells that, thanks to advanced technologies, tend to reproduce the development path of the brain of an embryo in the mother’s uterus.
Lavazza, Andrea, Pizzetti, Federico Gustavo   +1 more
openaire   +3 more sources

Generation of mouse hippocampal brain organoids from primary embryonic neural stem cells

STAR Protocols, 2023
Summary: Here we present a protocol to generate standardized cerebral organoids with hippocampal regional specification using morphogen WNT3a. We describe steps for isolating mouse embryonic (E14.5) neural stem cells from the brain subgranular zone ...
Francesca Ciarpella, Raluca Georgiana Zamfir, Alessandra Campanelli, Giulia Pedrotti, Marzia Di Chio, Emanuela Bottani, Ilaria Decimo   +6 more
doaj   +1 more source

Human cerebral organoids: the ethical stance of scientists

Stem Cell Research & Therapy, 2023
Abstract Background Human cerebral organoids (HCOs) offer unprecedented opportunities to study the human brain in vitro , but they also raise important ethical concerns. Here we report the first systematic analysis of scientists’
Andrea Lavazza, Alice Andrea Chinaia
openaire   +3 more sources

Modelling Toxoplasma gondii infection in human cerebral organoids

Emerging Microbes and Infections, 2020
Pluripotent stem cell-derived cerebral organoids have the potential to recapitulate the pathophysiology of in vivo human brain tissue, constituting a valuable resource for modelling brain disorders, including infectious diseases.
Hyang-Hee Seo, Hyo-Won Han, Sang-Eun Lee, Sung-Hee Hong, Shin-Hyeong Cho, Sang Cheol Kim, Soo Kyung Koo, Jung-Hyun Kim   +7 more
doaj   +1 more source

Knowledge graphs of ethical concerns of cerebral organoids

Cell Proliferation, 2022
AbstractObjectivesThe rapid development of cerebral organoid technology and the gradual maturity of cerebral organoids highlight the necessity of foresighted research on relevant ethical concerns. We employed knowledge graphs and conducted statistical analysis with CiteSpace for a comprehensive analysis of the status quo of the research on the ethical ...
Lulu Ding, Zhenyu Xiao, Xia Gong, Yaojin Peng   +3 more
openaire   +2 more sources

Cerebral organoids: ethical issues and consciousness assessment [PDF]

Journal of Medical Ethics, 2018
Organoids are three-dimensional biological structures grown in vitro from different kinds of stem cells that self-organise mimicking real organs with organ-specific cell types. Recently, researchers have managed to produce human organoids which have structural and functional properties very similar to those of different organs, such as the retina, the ...
Lavazza, Andrea, Massimini, Marcello
openaire   +3 more sources