Results 21 to 30 of about 913,373 (166)
Red Fluorescent Labeling of Myelin by Membrane‐Targeted tdTomato in Transgenic Mouse Lines [PDF]
Glia, Volume 74, Issue 12, December 2026.Transgenic mouse lines expressing membrane‐targeted tdTomato in myelin enable imaging of myelin in the red spectral range. Distinct expression patterns range from wide‐spread labeling to sparse single‐cell resolution, supporting diverse imaging applications.
Anja Reinert +15 more
wiley +2 more sources
Human SERPINA3 induces neocortical folding and improves cognitive ability in mice
Cell Discovery, 2022 Neocortex expansion and folding are related to human intelligence and cognition, but the molecular and cellular mechanisms underlying cortical folding remain poorly understood.
Jinyue Zhao +4 more
doaj +1 more source
iScience, 2023 Summary: Mutations in the human fasciculation and elongation protein zeta 1 (FEZ1) gene are found in schizophrenia and Jacobsen syndrome patients. Here, using human cerebral organoids (hCOs), we show that FEZ1 expression is turned on early during brain ...
Yinghua Qu +5 more
doaj +1 more source
LIF signaling regulates outer radial glial to interneuron fate during human cortical development [PDF]
, 2023 Radial glial (RG) development is essential for cerebral cortex growth and organization. In humans, the outer radial glia (oRG) subtype is expanded and gives rise to diverse neurons and glia.
Clara Siebert +37 more
core +1 more source
Human Cortical Organoids Expose a Differential Function of GSK3 on Cortical Neurogenesis
Stem Cell Reports, 2019 Summary: The regulation of the proliferation and polarity of neural progenitors is crucial for the development of the brain cortex. Animal studies have implicated glycogen synthase kinase 3 (GSK3) as a pivotal regulator of both proliferation and polarity,
Alejandro López-Tobón +18 more
doaj +1 more source
Müller glia activation in response to inherited retinal degeneration is highly varied and disease-specific [PDF]
, 2015 Despite different aetiologies, most inherited retinal disorders culminate in photoreceptor loss, which induces concomitant changes in the neural retina, one of the most striking being reactive gliosis by Müller cells.
Graca, AB +34 more
core +1 more source
The CTNNBIP1-CLSTN1 fusion transcript regulates human neocortical development
Cell Reports, 2021 Summary: Fusion transcripts or RNAs have been found in both disordered and healthy human tissues and cells; however, their physiological functions in the brain development remain unknown. In the analysis of deposited RNA-sequence libraries covering early
Min-Yi Ou +6 more
doaj +1 more source
Effects of glutamate receptor activation on NG2-glia in the rat optic nerve [PDF]
, 2009 NG2-glia are a substantial population of cells in the central nervous system (CNS) that can be identified by their specific expression of the NG2 chondroitin sulphate (CSPG).
Hubbard, Paul S. +8 more
core +1 more source
eLife, 2016 Cortical expansion and folding are often linked to the evolution of higher intelligence, but molecular and cellular mechanisms underlying cortical folding remain poorly understood. The hominoid-specific gene TBC1D3 undergoes segmental duplications during
Xiang-Chun Ju +9 more
doaj +1 more source
Morphological and physiological interactions of NG2-glia with astrocytes and neurons [PDF]
, 2007 Models of central nervous system (CNS) function have historically been based on neurons and their synaptic contacts - the neuronal doctrine. This doctrine envisages glia as passive supportive cells.
Hamilton, N. +12 more
core +1 more source