Results 21 to 30 of about 5,539,416 (160)
A multipotent transit-amplifying neuroblast lineage in the central brain gives rise to optic lobe glial cells in Drosophila [PDF]
, 2013 The neurons and glial cells of the Drosophila brain are generated by neural stem cell-like progenitors during two developmental phases, one short embryonic phase and one more prolonged postembryonic phase.
Reichert, Heinrich +5 more
core +1 more source
Protein & Cell, 2017 The development of a cerebral organoid culture in vitro offers an opportunity to generate human brain-like organs to investigate mechanisms of human disease that are specific to the neurogenesis of radial glial (RG) and outer radial glial (oRG) cells in ...
Rui Li +5 more
doaj +1 more source
Molecular Control of Neural Stem Cell Quiescence in the Adult Zebrafish Telencephalon: Established Mechanisms and an Integrative Hypothesis [PDF]
GliaAdult zebrafish radial glia quiescence is controlled by at least four mechanisms: Notch3, BMP‐Id1, Nr2f1b and Midkine‐a. We propose these act as partially redundant inputs, biased along the antero‐posterior axis that set quiescence depth. ABSTRACT The zebrafish telencephalon is an excellent model for adult neurogenesis under physiological and ...
Hoareau M, Diotel N, Rastegar S.
europepmc +2 more sources
A restricted period for formation of outer subventricular zone defined by Cdh1 and Trnp1 levels
Nature Communications, 2016 The outer subventricular zone (OSVZ) contains basal radial glial cells (bRGC) involved in cortical expansion in gyrencephalic mammals. Here the authors identify a developmental time window with marked production of bRGCs required to found the OSVZ that ...
Maria Ángeles Martínez-Martínez +5 more
doaj +1 more source
Scientific Reports, 2023 Human cortical organoids (hCOs), derived from human induced pluripotent stem cells (iPSCs), provide a platform to interrogate mechanisms of human brain development and diseases in complex three- dimensional tissues.
Elmira Jalilian, Su Ryon Shin
doaj +1 more source
Kcnv2 E151X Mouse Captures Hallmarks of KCNV2-Associated Retinal Dystrophy. [PDF]
Clin Exp OphthalmolABSTRACT Background KCNV2‐associated retinopathy is a rare inherited retinal dystrophy caused by variants in the KCNV2 gene, leading to disrupted photoreceptor behaviour and progressive deterioration of vision. Patients have characteristic electroretinography abnormalities, including reduced cone response, delayed and reduced rod response to low light ...
Xhaferri N +3 more
europepmc +2 more sources
Non-muscle myosins control the integrity of cortical radial glial endfeet [PDF]
, 2023 Radial glial cells, the stem cells of the cerebral cortex, extend a long basal fiber that ends in basal endfeet. A new study in PLOS Biology found that non-muscle myosins control basal endfoot integrity to regulate interneuron ...
Wang, Li +5 more
core +1 more source
Molecular Fate Determinants in Embryonic and Adult Neural Stem Cells [PDF]
, 2005 The molecular signals specifying neuronal, glial or multipotent precursors in the developing and adult central nervous system (CNS) are largely unknown. Radial glial cells have recently been discovered as major precursor population generating neurons or ...
Hack, M.A., Hack, Michael Anton
core +1 more source
Müller glia activation in response to inherited retinal degeneration is highly varied and disease-specific [PDF]
, 2015 Despite different aetiologies, most inherited retinal disorders culminate in photoreceptor loss, which induces concomitant changes in the neural retina, one of the most striking being reactive gliosis by Müller cells.
Graca, AB +34 more
core +1 more source
Cancer Communications, 2022 Glioblastoma multiforme (GBM) is the most aggressive and common malignant primary brain tumor. Patients with GBM often have poor prognoses, with a median survival of ∼15 months.
Elena Verdugo +2 more
doaj +1 more source