A mathematical model for spreading cortical depression
Biophysical Journal, 1978 A mathematical model is derived from physiological considerations for slow potential waves (called spreading depression) in cortical neuronal structures. The variables taken into account are the intra- and extracellular concentrations of Na+, Cl-, K+, and Ca++, together with excitatory and inhibitor transmitter substances.
Henry C. Tuckwell, R. M. Miura
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Vagus nerve stimulation inhibits cortical spreading depression exclusively through central mechanisms. [PDF]
Pain, 2020 Experimental and clinical data strongly support vagus nerve stimulation (VNS) as a novel treatment in migraine. VNS acutely suppresses cortical spreading depression (CSD) susceptibility, an experimental model that has been used to screen for migraine ...
Morais A +13 more
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Inhibition of HSP90 Preserves Blood–Brain Barrier Integrity after Cortical Spreading Depression [PDF]
Pharmaceutics, 2022 Cortical spreading depression (CSD) is a pathophysiological mechanism underlying headache disorders, including migraine. Blood–brain barrier (BBB) permeability is increased during CSD.
Seph M. Palomino +5 more
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A non-convulsant delta-opioid receptor agonist, KNT-127, reduces cortical spreading depression and nitroglycerin-induced allodynia. [PDF]
Headache, 2021 The aim of this study was to determine if the non‐convulsant delta‐opioid receptor (DOR) agonist, KNT‐127, could inhibit migraine‐associated endpoints.
Bertels Z +5 more
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Sarcoma Family Kinase-Dependent Pannexin-1 Activation after Cortical Spreading Depression is Mediated by NR2A-Containing Receptors. [PDF]
Int J Mol Sci, 2020 Cortical spreading depression (CSD) is a propagating wave of depolarization followed by depression of cortical activity. CSD triggers neuroinflammation via the pannexin-1 (Panx1) channel opening, which may eventually cause migraine headaches.
Bu F, Nie L, Quinn JP, Wang M.
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Study on “Atypical” Migraine Auras in the Pediatric Age: The Role of Cortical Spreading Depression and the Physiopathogenetic Hypothesis Arising from Our Clinical Cases [PDF]
Life, 2022 Migraine is a complex neurologic disorder by which several systems of the central nervous system (autonomous system, affective, cognitive, sensory and motor system) may be affected on different levels.
Vincenzo Raieli +5 more
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Characteristics of cortical spreading depression and c-Fos expression in transgenic mice having a mutation associated with familial hemiplegic migraine 2 [PDF]
Cephalalgia, 2020 Background Cortical spreading depression is thought to be the underlying mechanism of migraine aura. In 2006, three relatives having the point mutation E700K in ATP1A2 exon 15 were diagnosed with familial hemiplegic migraine 2 characterized by ...
Chunhua Tang +9 more
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Cortical spreading depression-induced preconditioning in the brain
Neural Regeneration Research, 2016 Cortical spreading depression is a technique used to depolarize neurons. During focal or global ischemia, cortical spreading depression-induced preconditioning can enhance tolerance of further injury. However, the underlying mechanism for this phenomenon
Ping-ping Shen +8 more
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Cortical Spreading Depression Denotes Concussion Injury. [PDF]
J Neurotrauma, 2019 Cortical spreading depression (CSD) has been described after moderate-to-severe traumatic brain injury (TBI). It is uncertain, however, whether CSD occurs after mild, concussive TBI and whether it relates to brain pathology and functional outcome.
Bouley J +4 more
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Correction: Mechanisms of initiation of cortical spreading depression [PDF]
The Journal of Headache and Pain, 2023 Marina Vitale +4 more
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