Results 41 to 50 of about 516,590 (413)

Reverse-Bayes methods for evidence assessment and research synthesis [PDF]

, 2021
It is now widely accepted that the standard inferential toolkit used by the scientific research community -- null-hypothesis significance testing (NHST) -- is not fit for purpose. Yet despite the threat posed to the scientific enterprise, there is no agreement concerning alternative approaches for evidence assessment.
arxiv   +1 more source

Persistent discharge or edema after endoscopic sinus surgery in patients with chronic rhinosinusitis is associated with a type 1 or 3 endotype

International Forum of Allergy &Rhinology, Volume 13, Issue 1, Page 15-24, January 2023., 2023
Abstract Background Patients with chronic rhinosinusitis (CRS) may have persistence of polyps, discharge, or edema after endoscopic sinus surgery (ESS). Inflammation in CRS can be classified into three endotypes, with the presence of polyps associated with the type 2 endotype.
Eli Stein, Alexander L. Schneider, Regan Harmon, Samuel D. Racette, Abhita T. Reddy, Caroline P. E. Price, Julia H. Huang, Atsushi Kato, Stephanie Shintani‐Smith, David B. Conley, Kevin C. Welch, Robert C. Kern, Bruce K. Tan   +12 more
wiley   +1 more source

Comparison of standard dose with high dose of methylprednisolone in the management of COVID-19 patients admitted in ICU

Journal of Family Medicine and Primary Care, 2021
Context: The pathological progression in severe Coronavirus Disease 2019 (COVID-19) includes an excessive and unregulated pro-inflammatory cytokine storm.
Abhishek Singhai, Parneet Kaur Bhagtana, Neeraj Pawar, G Sai Pavan   +3 more
doaj   +1 more source

A transcriptome-driven analysis of epithelial brushings and bronchial biopsies to define asthma phenotypes in U-BIOPRED [PDF]

, 2016
RATIONALE AND OBJECTIVES: Asthma is a heterogeneous disease driven by diverse immunologic and inflammatory mechanisms. We used transcriptomic profiling of airway tissues to help define asthma phenotypes. METHODS: The transcriptome from bronchial biopsies
Adcock, IM, Auffray, C, Baribaud, F, Chanez, P, Chung, KF, Corfield, J, Dahlen, B, Dahlen, SE, De Meulder, B, Djukanovic, R, Fleming, L, Fowler, S, Guo, Y, Hoda, U, Howarth, P, Krug, N, Kuo, CS, Lefaudeux, D, Loza, M, Pandis, I, Pavlidis, S, Rossios, C, Rowe, A, Sandström, T, Shaw, D, Sousa, A, Sterk, PJ, U-BIOPRED Project Team, Wilson, SJ   +28 more
core   +4 more sources

Efficacy of the exhalation delivery system with fluticasone in patients with chronic rhinosinusitis with nasal polyps whose symptoms recur after sinus surgery

International Forum of Allergy &Rhinology, Volume 13, Issue 1, Page 31-41, January 2023., 2023
Abstract Background Sinus surgery removes inflamed tissue, restores airflow, and improves delivery of medication into surgically opened spaces. The exhalation delivery system with fluticasone (EDS‐FLU; XHANCE®) uses a novel delivery system to create closed‐palate, positive‐pressure, bidirectional mechanics that significantly alter the deposition of the
Randall A. Ow, Zachary M. Soler, Raj Sindwani, Donald A. Leopold, Jivianne T. Lee, Ramy A. Mahmoud, Joseph K. Han   +6 more
wiley   +1 more source

Relationship Between Blood Eosinophils and Systemic Corticosteroid Therapy in COPD Exacerbation

International Journal of General Medicine, 2022
Yaya Gong, Hongyan Sun Department of Respiratory Medicine, Anhui No.2 Provincial People’s Hospital, Hefei, People’s Republic of ChinaCorrespondence: Hongyan Sun, Tel +86 13856934496, Email sunhyanah@126.comPurpose: To assess the relationship between the ...
Gong Y, Sun H
doaj  

Choroidal changes in eyes treated with high-dose systemic corticosteroids for optic neuritis [PDF]

International Journal of Ophthalmology, 2020
AIM: To analyze the effect of systemic high-dose corticosteroid on the choroid in patients with unilateral optic neuritis. METHODS: A retrospective comparative cohort study.
Jun Hyuk Lee, Ji Young Lee, Ho Ra, Nam Yeo Kang, Jiwon Baek   +4 more
doaj   +1 more source

Corticosteroid Activation of Atlantic Sea Lamprey Corticoid Receptor: Allosteric Regulation by the N-terminal Domain [PDF]

arXiv, 2022
Lampreys are jawless fish that evolved about 550 million years ago at the base of the vertebrate line. Modern lampreys contain a corticoid receptor (CR), the common ancestor of the glucocorticoid receptor (GR) and mineralocorticoid receptor (MR), which first appear in cartilaginous fish, such as sharks.
arxiv  

Smoking in asthma is associated with elevated levels of corticosteroid resistant sputum cytokines—an exploratory study [PDF]

, 2013
<p>Background: Current cigarette smoking is associated with reduced acute responses to corticosteroids and worse clinical outcomes in stable chronic asthma. The mechanism by which current smoking promotes this altered behavior is currently unclear.
A McKay, A Sykes, B Pedersen, Carl de Wet, Charles McSharry, Christopher J. Weir, E Goleva, E Goleva, E Irusen, E Juniper, E Livingston, GJ Zijlstra, GW Chalmers, GW Chalmers, H Kerstjens, J Kam, J St-Laurent, JEM Tomlinson, M Althuis, M Broekema, M Spears, Marco Idzko, Mark Spears, MR Edwards, MR Miller, MR Stämpfli, NC Thomson, Neil C. Thomson, R Chaudhuri, R Chaudhuri, R Crapo, R Meijer, R Sher, Rekha Chaudhuri, S Holgate, SC Lazarus, SE Pedersen, SE Wenzel, WE Naugler, Z Qiu, Z Xing   +40 more
core   +4 more sources

Systemic corticosteroids for acute otitis media in children [PDF]

, 2018
Background: Acute otitis media (AOM) is a common acute infection in children. Pain is its most prominent and distressing symptom. Antibiotics are commonly prescribed for AOM, although they have only a modest effect in reducing pain at two to three days.
Beller, Elaine M, Del Mar, Chris B, Pitoyo, Yupitri, Ranakusuma, Respati W, Safitri, Eka D, Sastroasmoro, Sudigdo, Thorning, Sarah   +6 more
core   +1 more source