Results 91 to 100 of about 484,106 (362)
Optic perineuritis: a retrospective case series
International Medical Case Reports Journal, 2017 Olle Bergman,1 Tommy Andersson,1 Madeleine Zetterberg1,2 1Department of Ophthalmology, Sahlgrenska University Hospital, 2Department of Clinical Neuroscience/Ophthalmology, Institute of Neuroscience and Physiology, University of Gothenburg, Mö ...
Bergman O, Andersson T, Zetterberg M
doaj
Journal of Blood Medicine, 2021 Fei Song,1,2 Hanny Al-Samkari2,3 1Department of Medicine, Massachusetts General Hospital, Boston, MA, USA; 2Harvard Medical School, Boston, MA, USA; 3Division of Hematology, Massachusetts General Hospital, Boston, MA, USACorrespondence: Hanny Al ...
Song F, Al-Samkari H
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A clinical case of fatal familial insomnia with a transient positive response to corticosteroids
Анналы клинической и экспериментальной неврологии, 2020 Fatal familial insomnia (FFI) is a rare genetic human prion disease with an autosomal dominant pattern of inheritance caused by a D178N mutation in the PRNP gene. FFI is characterized by a variable clinical presentation and subacute manifestation.
Yulia A. Shpilyukova +2 more
doaj +1 more source
An audit of compliance of inhaled steroid medication in Maltese asthmatic children : a comparison between 2008 and 2014 [PDF]
, 2014 In the treatment of bronchial asthma, inhaled therapy with bronchodilators and corticosteroids represents the basis for acute and long-term management. Drug therapy in asthma is predominantly by pressurized metered dose inhalers.
Bezzina, Gianluca +2 more
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, 2008 INTRODUCTION: Gout affects about 5% of men and 1% of women, with up to 80% of people experiencing a recurrent attack within 3 years. METHODS AND OUTCOMES:We conducted a systematic review and aimed to answer the following clinical questions: What are the
Underwood, Martin
core +3 more sources
SUMOylation is a Translatable Target in Hypoxic MNPs Regulating Retinal Vasculopathy
Advanced Science, EarlyView.During ischemic retinopathy/retinal vasculopathy, UBC9‐mediated SUMOylation in retinal macrophages enhances their pro‐angiogenic capacity via hypoxia‐induced SUMOylation of FUS at K327/K502. This modification suppresses FUS binding to the Vegfa mRNA 3’UTR, stabilizing transcripts and facilitating VEGFA production. Targeting UBC9 inhibition can serve as
Zheng Zhong +9 more
wiley +1 more source
Advanced Science, EarlyView.Herpes Simplex Virus Type 1 (HSV‐1) infection triggers metabolic reprogramming in corneal cells, shifting from mitochondrial respiration to aerobic glycolysis with marked upregulation of Hexokinase‐2 (HK2). This study identifies HK2 as a therapeutic target: inhibiting HK2 with lonidamine significantly reduces viral replication and promotes corneal ...
Dan Jiang +9 more
wiley +1 more source
Clinical Efficacy of Corticosteroids in the Early Stages of Deterioration in COVID-19 Pneumonia
Infection and Drug Resistance, 2021 Zheng Liu,1,* Fang Shi,1 Jun-Xia Liu,1 Jia-Qi Liu,2 Jing Li,1 Qian Wang,1 Hui Wang,1 Chang-Lan Gao,3 Jian-Min Li,1 Dong-Fang Zhao1,* 1Department of Respiratory Medicine, The Petroleum Clinical Medical College of Hebei Medical University, Langfang,
Liu Z +9 more
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Symptomatic adrenal insufficiency during inhaled corticosteroid treatment [PDF]
, 2001 Symptomatic adrenal insufficiency, presenting as hypoglycaemia or poor weight gain, may occur on withdrawal of corticosteroid treatment but has not previously been reported during inhaled corticosteroid treatment.
Clayton, P.E. +5 more
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The Immune Microenvironment: New Therapeutic Implications in Organ Fibrosis
Advanced Science, EarlyView.This review summarizes recent advances in understanding the immune microenvironment's role in fibrosis, focusing on phenotypic/functional alterations of immune cells and their dynamic interactions with other cellular constituents within tissues. The authors further explore therapeutic opportunities and challenges in targeting immune microenvironment ...
Xiangqi Chen +6 more
wiley +1 more source