Results 101 to 110 of about 10,599 (209)

Synapse elimination and learning rules co-regulated by MHC class I H2-Db. [PDF]

, 2014
The formation of precise connections between retina and lateral geniculate nucleus (LGN) involves the activity-dependent elimination of some synapses, with strengthening and retention of others. Here we show that the major histocompatibility complex (MHC)
Adelson, Jaimie, Brott, Barbara, Cheng, Sarah, Datwani, Akash, Feller, Marla, Kirkby, Lowry, Lee, Hanmi, Shatz, Carla   +7 more
core   +3 more sources

Neuromeric Organization of the Microbat Brain: Conserved and Distinct Regional Features

Journal of Comparative Neurology, Volume 534, Issue 2, February 2026.
The fundamental neuromeric modular plan is remarkably conserved across bats and rodents. However, there are significant regional differences in the size and organization of specific derivatives (A). In addition, both Tadarida brasiliensis and Myotis myotis share similar general patterns of TH‐positive processes and tracts in the basal plate of the ...
F. Lucero‐Arteaga, A. Abrego‐Alvarez, M. Clauzure, S. Labegorra, V. Heck, A. I. Portu, M. A. Boeris, M. A. Mondino, B. Ribeiro Do‐Couto, K. Y. Tseng, M. Á. García‐Cabezas, J. L. Ferran   +11 more
wiley   +1 more source

A cortical motor nucleus drives the basal ganglia-recipient thalamus in singing birds [PDF]

, 2011
The pallido-recipient thalamus transmits information from the basal ganglia to the cortex and is critical for motor initiation and learning. Thalamic activity is strongly inhibited by pallidal inputs from the basal ganglia, but the role of nonpallidal ...
A Leblois, A Pasupathy, A Yoshida, AB Butler, AJ Doupe, AL Person, AL Person, AM Graybiel, AP Georgopoulos, AS Andalman, C Scharff, D Aronov, D Aronov, D Jeanmonod, D Pare, DA Coulter, ED Jarvis, EF Foster, G Chevalier, GE Vates, H Markram, J Kunimatsu, Jesse H Goldberg, JH Goldberg, JH Goldberg, JM Deniau, JM Deniau, JM Wild, JW Mink, K Kultas-Ilinsky, L Veit, M Inase, M Luo, M Okun, ME Anderson, ME Anderson, ME Anderson, Michale S Fee, MR DeLong, MS Fee, NR McFarland, O Hikosaka, PL Strick, RL Albin, RR Llinas, S Kojima, SA Sheth, SW Bottjer, TL Warren, TP Vogels   +49 more
core   +1 more source

Cortical Type: The Basis for a Modern Neurodevelopmental Synthesis (Ontogeny, Phylogeny, Synaptic Connectivity) of the Human Cerebral Cortex

Journal of Comparative Neurology, Volume 534, Issue 2, February 2026.
The parcellation of cortical types along the gradient of laminar complexity of the human cerebral cortex provides the basis for a Modern Neurodevelopmental Synthesis. This synthesis integrates ontogeny, phylogeny, gene expression, receptor architecture, cellular features, and synaptic connectivity and aims to guide experimental design for human ...
Josefa Zaldivar‐Diez, Miguel Ángel García‐Cabezas   +1 more
wiley   +1 more source

Diffuse neural coupling mediates complex network dynamics through the formation of quasi-critical brain states

Nature Communications, 2020
A principle of neuroanatomy, namely diffuse connectivity, is modeled using a large-scale network of corticothalamic neural masses. We demonstrate that increases in diffuse coupling transition the system through a quasi-critical regime, which coincides ...
Eli J. Müller, Brandon R. Munn, James M. Shine   +2 more
doaj   +1 more source

Single‐Nucleus RNA Sequencing Reveals Mid‐Gestational Neurodevelopment Features in the Superior Temporal Plane from Fetuses with Nonsyndromic Cleft Lip and Palate

Advanced Science, Volume 13, Issue 1, 5 January 2026.
Single‐nucleus RNA sequencing of mid‐gestation brains from fetuses with nonsyndromic cleft lip and palate reveals major disruptions in cell composition, cell‐to‐cell signaling, and gene regulation. The transcription factor MEF2C is identified as a central regulator of these changes and shows that lowering MEF2C impairs synapse formation, linking cleft ...
Liu‐Lin Xiong, Xin‐Wei Huang, Qiu‐Xia Xiao, Ying‐Gang Zheng, Hao‐Yue Qin, Chang‐Le Fang, Li Chen, Ruo‐Lan Du, Qiu‐Lin Wang, Li‐Ren Huangfu, Ye‐Qing Fei, Yang‐Yang Zhao, Chen‐Yang Zhai, Ze‐Mian Chen, Shi‐Kun Yuan, Yu‐Ji Zhou, Xing‐Man He, Ting‐Ting Zhi, Xiao‐He Tian, Ting‐Hua Wang   +19 more
wiley   +1 more source

Variation in Activity State, Axonal Projection, and Position Define the Transcriptional Identity of Individual Neocortical Projection Neurons

Cell Reports, 2018
Summary: Single-cell RNA sequencing has generated catalogs of transcriptionally defined neuronal subtypes of the brain. However, the cellular processes that contribute to neuronal subtype specification and transcriptional heterogeneity remain unclear. By
Maxime Chevée, Johanna De Jong Robertson, Gabrielle Heather Cannon, Solange Pezon Brown, Loyal Andrew Goff   +4 more
doaj   +1 more source

NAD⁺ Reduction in Glutamatergic Neurons Induces Lipid Catabolism and Neuroinflammation in the Brain via SARM1

Advanced Science, Volume 13, Issue 6, 30 January 2026.
NAD⁺ homeostasis maintains neuronal integrity through opposing actions of NMNAT2 and SARM1. Loss of NMNAT2 in glutamatergic neurons reprograms cortical metabolism from glucose to lipid catabolism, depletes lipid stores, and triggers inflammation and neurodegeneration.
Zhen‐Xian Niou, Sen Yang, Andrea Enriquez, Nino A. Espinas, Anoosha Sri, Caliel D. Hines, Jason M. Tennessen, Chia‐Shan Wu, Jui‐Yen Huang, Hui‐Chen Lu   +9 more
wiley   +1 more source

Ablation of CNTN2+ Pyramidal Neurons During Development Results in Defects in Neocortical Size and Axonal Tract Formation

Frontiers in Cellular Neuroscience, 2019
Corticothalamic axons express Contactin-2 (CNTN2/TAG-1), a neuronal recognition molecule of the immunoglobulin superfamily involved in neurogenesis, neurite outgrowth, and fasciculation. TAG-1, which is expressed transiently by cortical pyramidal neurons
Maria Eleni Kastriti, Maria Eleni Kastriti, Maria Eleni Kastriti, Maria Eleni Kastriti, Aikaterini Stratigi, Aikaterini Stratigi, Aikaterini Stratigi, Dimitris Mariatos, Dimitris Mariatos, Marina Theodosiou, Marina Theodosiou, Marina Theodosiou, Maria Savvaki, Maria Savvaki, Michaela Kavkova, Kostas Theodorakis, Kostas Theodorakis, Marina Vidaki, Marina Vidaki, Marina Vidaki, Marina Vidaki, Tomas Zikmund, Jozef Kaiser, Igor Adameyko, Igor Adameyko, Domna Karagogeos, Domna Karagogeos   +26 more
doaj   +1 more source

Presence of a Chaotic Region at the Sleep-Wake Transition in a Simplified Thalamocortical Circuit Model

Frontiers in Computational Neuroscience, 2016
Sleep and wakefulness are characterized by distinct states of thalamocortical network oscillations. The complex interplay of ionic conductances within the thalamo-reticular-cortical network give rise to these multiple modes of activity and a rapid ...
Kush Paul, Kush Paul, Daniel A Llano
doaj   +1 more source