Results 41 to 50 of about 515,964 (279)

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

EVALUATION OF CORTICOTROPIN RELEASING HORMONE (CRH) IN PREECLAMPSIA

Pakistan Armed Forces Medical Journal, 2010
Background: CRH level is increased during normal pregnancy as it is released from the placenta. This implies a definite role of CRH in pregnancy or labor.
Dr Asmat Kamal Ansari, Salma Farrukh Memon, Shahzeen Fatima   +2 more
doaj   +2 more sources

Gonadotropin‐Inhibitory Hormone (GnIH) and Its Receptor GPR147 Mediates Acute Stress‐Induced Activation of the Locus Coeruleus‐SAM Axis

Advanced Science, EarlyView.
ABSTRACT Gonadotropin‐inhibitory hormone (GnIH, also known as RFamide‐related peptide‐3, RFRP‐3) is a hypothalamic neuropeptide that regulates vertebrate reproduction via its receptor GPR147. Although GnIH is known to mediate stress‐induced reproductive suppression, its role in broader stress responses remains unclear.
Jiani Zhang, Hongyu Zhu, Wenqi Wang, Bingqian Shen, Yuanyuan Xin, Xingxing Song, Xuanyi Lu, Lixuan Li, Siting Chen, Xiaochen Zhang, Jialing Zeng, Haodong Zheng, Jianlong Lao, Ke Peng, Yixian Wei, Jiaming Zheng, Chuanhuo Hu, Xiaoye Wang, Xun Li   +18 more
wiley   +1 more source

Pathophysiology of Infantile Spasms

Pediatric Neurology Briefs, 1993
An age-specific endogenous-convulsant hypothesis implicating corticotropin-releasing hormone (CRH), an excitant neuropeptide suppressed by ACTH/steroids, is proposed for the pathophysiology of massive infantile spasms in a report from the University of ...
J Gordon Millichap
doaj   +1 more source

Effects of loperamide on the human hypothalamo-pituitary-adrenal axis in vivo and in vitro. [PDF]

, 1992
Loperamide, an opiate agonist of high specificity for p-receptors, was recently reported to suppress ACTH and cortisol levels in normal subjects, but not in patients with proven ACTH-dependent Cushing’s disease. However, there is little information on
Pfeiffer, M., Lange, M., Auernhammer, Christoph J., Stalla, G.K., Müller, O.A.   +4 more
core   +2 more sources

Multi‐Layer Transcriptomic Comparison Across Human, Pig, and Mouse Informs Tissue‐ and Trait‐Specific Animal Model Selection

Advanced Science, EarlyView.
We integrated RNA‐seq data from humans, pigs, and mice across 15 matched tissues based on 14 910 one‐to‐one orthologous genes. Cross‐species similarity was systematically evaluated across multiple regulatory layers, including global co‐expression conservation, co‐expression networks, tissue‐specific programs, and 3D genome architecture.
Jingwen Dou, Yong Liao, Xiong Shen, Xin Huang, Zhenshuang Tang, Yuwei Gou, Huajun Zhou, Jingya Xu, Hong Liu, Yue Wang, Keke Liang, Jia Liu, Xiao Zhang, Chenyao Li, Shangjian Wang, Liangliang Fu, Lilin Yin, Xinyun Li, Shuhong Zhao, Xiaolei Liu, Jingjin Li, Yuhua Fu   +21 more
wiley   +1 more source

Corticotropin releasing hormone promotes inflammatory bowel disease via inducing intestinal macrophage autophagy

Cell Death Discovery, 2021
Psychosocial stress is a vital factor contributing to the pathogenesis and progression of inflammatory bowel disease (IBD). The contribution of intestinal macrophage autophagy to the onset and development of IBD has been widely studied.
Sheng-Bing Zhao, Jia-Yi Wu, Zi-Xuan He, Yi-Hang Song, Xin Chang, Tian Xia, Xue Fang, Zhao-Shen Li, Can Xu, Shu-Ling Wang, Yu Bai   +10 more
doaj   +1 more source

Elevated Corticotropin-Releasing Hormone in Human Pregnancy Increases the Risk of Postpartum Depressive Symptoms [PDF]

, 2009
Postpartum depression (PPD) is common and has serious implications for the mother and her newborn. A possible link between placental corticotropin-releasing hormone (pCRH) and PPD incidence has been discussed, but there is a lack of empirical ...
Hobel, Calvin J., Hobel, Calvin J, Glynn, Laura M, Schetter, Christine Dunkel, Glynn, Laura M., Chicz-DeMet, Aleksandra, Yim, Ilona S, Yim, Ilona S., Sandman, Curt A., Sandman, Curt A   +9 more
core   +1 more source

A Hypothalamic Oxytocinergic–Sympathetic Axis Couples Anxiety Dysregulation With Impaired Tendon–Bone Repair

Advanced Science, EarlyView.
RCI is associated with functional suppression of oxytocinergic neurons in the PVN. Reduced PVNOXT neuronal activity contributes to altered sympathetic regulation involving the IML–sympathetic chain pathway, accompanied by changes in norepinephrine signaling at the BTI.
Liyang Wan, Tingmo Huang, Liyue Zeng, Ruixue Du, Hengshuo Zhang, Shen Liu, Tao Zhang, Jianzhong Hu, Hongbin Lu   +8 more
wiley   +1 more source

Corticotropin-releasing hormone increases prostaglandin F2 alpha activity on human myometrium in vitro

, 1994
OBJECTIVE: Our purpose was to study the capability of synthetic corticotropin-releasing hormone to directly stimulate human myometrium and to modulate the activity of prostaglandins F2 alpha and E2.
Chiarolini, L., Marozio, L, Florio, P, PETRAGLIA, Felice, Marozio, L., GENAZZANI, Andrea Riccardo, Chiarolini L, Florio P, Massobrio M., Petraglia F, Massobrio, M., Benedetto, C, GENAZZANI, ANDREA, Benedetto, C., Benedetto C, Petraglia, F., Chiarolini, L, Florio, P., Genazzani, A. R., Marozio L   +19 more
core   +1 more source