Results 21 to 30 of about 515,964 (279)

Epigenetic Changes in the CRH Gene are Related to Severity of Suicide Attempt and a General Psychiatric Risk Score in Adolescents

EBioMedicine, 2018
The aim of this study, comprising 88 suicide attempters, was to identify hypothalamic-pituitary-adrenal (HPA) -axis coupled CpG-sites showing methylation shifts linked to severity of the suicide attempt.
Jussi Jokinen, Adrian E. Boström, Ali Dadfar, Diana M. Ciuculete, Andreas Chatzittofis, Marie Åsberg, Helgi B. Schiöth   +6 more
doaj   +1 more source

Corticotropin-releasing factor receptor signaling and modulation: implications for stress response and resilience

Trends in Psychiatry and Psychotherapy, 2020
Introduction In addition to their role in regulation of the hypothalamic-pituitary-adrenal-axis, corticotropin-releasing factor (CRF) and its related peptides, the urocortins, are important mediators of physiological and pathophysiological processes of ...
Mailton Vasconcelos, Dirson J. Stein, Matheus Gallas-Lopes, Luane Landau, Rosa Maria M. de Almeida   +4 more
doaj   +1 more source

“Reproductive” Corticotropin‐Releasing Hormone

Annals of the New York Academy of Sciences, 2006
Abstract:  Corticotropin‐releasing hormone (CRH), a 41 amino acid peptide, is an important regulatory molecule synthesized by neurons of the parvocellular and magnocellular hypothalamic paraventricular nuclei. It acts as the major physiologic corticotropin (ACTH) secretagogue. The CRH gene is located in humans on chromosome 8.
Vitoratos, N., Papatheodorou, D.C., Kalantaridou, S.N., Mastorakos, G.   +3 more
openaire   +4 more sources

Differential Expression of CRH, UCN, CRHR1 and CRHR2 in Eutopic and Ectopic Endometrium of Women with Endometriosis. [PDF]

, 2013
Endometriosis is considered as a benign aseptic inflammatory disease, characterised by the presence of ectopic endometrium-like tissue. Its symptoms (mostly pain and infertility) are reported as constant stressors.
Sabatini, Luca, Aikaterini Vergetaki, Antonis Makrigiannakis, Vergetaki, Aikaterini, Jeschke, Udo, Taliouri, Eirini, Evangelia A Papakonstanti, Papakonstanti, Evangelia A., Udo Jeschke, Thomas Vrekoussis, Vrekoussis, Thomas, Eirini Taliouri, Luca Sabatini, Makrigiannakis, Antonis, Sabatini Luca, Papakonstanti Evangelia A., Makrigiannakis Antonis, Jeschke Udo, Taliouri Eirini, Vergetaki Aikaterini, Vrekoussis Thomas   +20 more
core   +2 more sources

Corticotropin releasing hormone as an identifier of bronchiolitis obliterans syndrome

Scientific Reports, 2022
Lung transplantion (LTx) recipients have low long-term survival and a high incidence of bronchiolitis obliterans syndrome (BOS), an inflammation of the small airways in chronic rejection of a lung allograft.
Anna Niroomand, Haider Ghaidan, Oskar Hallgren, Lennart Hansson, Hillevi Larsson, Darcy Wagner, Martina Mackova, Kieran Halloran, Snejana Hyllén, Sandra Lindstedt   +9 more
doaj   +1 more source

Corticotropin-releasing factor receptors couple to multiple g-proteins to activate diverse intracellular signaling pathways in mouse hippocampus: role in neuronal excitability and associative learning [PDF]

, 2003
Corticotropin-releasing factor (CRF) exerts a key neuroregulatory control on stress responses in various regions of the mammalian brain, including the hippocampus.
Nijholt, I., Thomas Blank, Spiess, Joachim, Blank, Thomas, Spiess, J., Randeva, H., Hillhouse, E., Nijholt, Ingrid, Edward W. Hillhouse, Grammatopoulos, Dimitris K., Grammatopoulos, D., Joachim Spiess, Blank, T., Randeva, Harpal S., Grammatopoulos, Dimitris, Blank, T. (Thomas), Dimitris K. Grammatopoulos, Hillhouse, Edward W., Harpal S. Randeva, Ingrid Nijholt   +19 more
core   +1 more source

Involvement of the hypothalamic-pituitary-thyroid axis and its interaction with the hypothalamic-pituitary-adrenal axis in the ontogeny of avian thermoregulation: a review [PDF]

, 2008
The emergence of thermoregulation in avian species is a complex matter in which neural as well as hormonal processes are involved. In a previous paper, the neural aspects of primary avian thermoregulation were discussed.
Brand, H., van den, Kemp, B., Bruggeman, V., Debonne, M., Decuypere, E., Baarendse, P.J.J., E. DECUYPERE, V. BRUGGEMAN, M. DEBONNE, P.J.J. BAARENDSE, H. VAN DEN BRAND, B. KEMP   +11 more
core   +1 more source

Corticotropin‐releasing hormone–induced seizures in infant rats originate in the amygdala [PDF]

, 1992
The neuroanatomical substrate of seizures induced by picomolar amounts of corticotropin-releasing hormone in infant rats was investigated. Electrographic and behavioral phenomena were monitored in 42 rat pups aged 5 to 22 days.
O. Carter Snead, Tallie Z. Baram, Linda Schultz, Schultz, L, Snead, O Carter, Snead, OC, Baram, Tallie Z, Schultz, Linda, Hirsch, Edouard, Hirsch, E, Baram, TZ, Edouard Hirsch   +11 more
core   +1 more source

Mechanism of Anticonvulsant Action of ACTH

Pediatric Neurology Briefs, 2001
The hypothesis that systemic or intraventricular administration of corticotropin (ACTH) acts directly on limbic neurons to modulate corticotropin-releasing hormone (CRH) gene expression, independently of adrenal stimulation, was tested and confirmed in ...
J Gordon Millichap
doaj   +1 more source

Human fear acquisition deficits in relation to genetic variants of the corticotropin releasing hormone receptor 1 and the serotonin transporter. [PDF]

PLoS ONE, 2013
The ability to identify predictors of aversive events allows organisms to appropriately respond to these events, and failure to acquire these fear contingencies can lead to maladaptive contextual anxiety.
Ivo Heitland, Lucianne Groenink, Elisabeth Y Bijlsma, Ronald S Oosting, Johanna M P Baas   +4 more
doaj   +1 more source