Results 61 to 70 of about 39,594 (255)

Characterization of Xi-class mycothiol S-transferase from Corynebacterium glutamicum and its protective effects in oxidative stress

Microbial Cell Factories, 2019
Background Oxidative stress caused by inevitable hostile conditions during fermentative process was the most serious threat to the survival of the well-known industrial microorganism Corynebacterium glutamicum. To survive, C. glutamicum developed several
Meiru Si, Chengchuan Che, Guanxi Li, Xiaona Li, Zhijin Gong, Jinfeng Liu, Ge Yang, Can Chen   +7 more
doaj   +1 more source

Two Novel S‐methyltransferases Confer Dimethylsulfide Production in Actinomycetota

Advanced Science, EarlyView.
This study identifies two novel S‐adenosine‐methionine‐dependent methyltransferases, MddM1 and MddM2, in actinomycetes from the Mariana Trench. These enzymes can convert toxic hydrogen sulfide (H2S) and methanethiol (MeSH) into dimethylsulfide (DMS), serving as a cellular detoxification and oxidative stress response.
Ruihong Guo, Zihua Guo, Yi Zhou, Yunhui Zhang, Haojin Cheng, Rebecca Devine, Chuang Sun, Ronghua Liu, Yanfen Zheng, Andrew J. Gates, Jonathan D. Todd, Xiao‐Hua Zhang   +11 more
wiley   +1 more source

Accelerating Enzyme Engineering With Artificial Intelligence in Biocatalysis: Challenges and Opportunities

Food Bioengineering, EarlyView.
ABSTRACT Artificial intelligence (AI) has emerged as a paradigm‐shifting force in enzyme engineering, enabling data‐driven prediction of catalytic activity, stability, and substrate specificity. By integrating large‐scale datasets from structured databases (e.g., PDB, BRENDA) and high‐throughput experimentation (e.g., deep mutational scanning ...
Xiafeng Lu, Min Cao, Muqing Ma, Yan Wu, Maohua Qu, Feng Du, Rongtao Ji, Mimi Duan, Leichi Dong, Kai Liu, Xueqi Zhang, Zhibo Luo   +11 more
wiley   +1 more source

The Actinobacterium Corynebacterium glutamicum, an Industrial Workhorse

Journal of Microbiology and Biotechnology, 2016
Starting as a glutamate producer, Corynebacterium glutamicum has played a variety of roles in the industrial production of amino acids, one of the most important areas of white biotechnology. From shortly after its genome information became available, C.
Joo-Young, Lee, Yoon-Ah, Na, Eungsoo, Kim, Heung-Shick, Lee, Pil, Kim   +4 more
openaire   +2 more sources

Metabolic engineering of Corynebacterium glutamicum for high-level ectoine production - design, combinatorial assembly and implementation of a transcriptionally balanced heterologous ectoine pathway.

Biotechnology Journal, 2019
Ectoine (1,4,5,6-tetrahydro-2-methyl-4-pyrimidine-carboxylic acid) is formed in various bacteria as a cell protectant against all kinds of stress. Its preservative and protective effects on proteins, cells, and tissues have enabled various applications ...
Gideon Gießelmann, Demian Dietrich, Lukas Jungmann, Michael Kohlstedt, Eun-Jung Jeon, S. Yim, Frederik Sommer, David Zimmer, Timo Mühlhaus, M. Schroda, K. Jeong, Judith Becker, C. Wittmann   +12 more
semanticscholar   +1 more source

Proteome Analysis of Corynebacterium diphtheriae–Macrophage Interaction

PROTEOMICS, EarlyView.
ABSTRACT Contact of Corynebacterium diphtheriae with macrophages induces adaptations on both bacterial and cellular sides. The study presented here was aiming to shed light on the simultaneous intracellular adaptation of the bacteria and changes in the proteome of the phagocytes in response to the internalization of C. diphtheriae.
Luca Musella, Jens Möller, Christopher Lischer, Julio Vera‐Gonzalez, Jörg Hofmann, Lisa Ott, Andreas Burkovski   +6 more
wiley   +1 more source

PEARL: Protein Eluting Alginate with Recombinant Lactobacilli

Small, EarlyView.
Probiotic lactobacilli meet engineered living materials: This study introduces PEARL (protein eluting alginate with recombinant lactobacilli), an innovative engineered living material combining Lactiplantibacillus plantarum and alginate beads for controlled protein release.
Varun Sai Tadimarri, Marc Blanch‐Asensio, Ketaki Deshpande, Jonas Baumann, Carole Baumann, Rolf Müller, Sara Trujillo, Shrikrishnan Sankaran   +7 more
wiley   +1 more source

Silencing of cryptic prophages inCorynebacterium glutamicum [PDF]

Nucleic Acids Research, 2016
DNA of viral origin represents a ubiquitous element of bacterial genomes. Its integration into host regulatory circuits is a pivotal driver of microbial evolution but requires the stringent regulation of phage gene activity. In this study, we describe the nucleoid-associated protein CgpS, which represents an essential protein functioning as a ...
Pfeifer, Eugen, Hünnefeld, Max, Popa, Ovidiu, Polen, Tino, Kohlheyer, Dietrich, Baumgart, Meike, Frunzke, Julia   +6 more
openaire   +3 more sources

PRODUKSI L-LISIN OLEH GALUR MUTAN Corynebacterium glutamicum DENGAN MEMANFAATKAN MOLASE L-LYSINE PRODUCTION BY MUTANT STRAINS OF Corynebacterium glutamicum USING MOLASSES

Jurnal Teknologi dan Industri Pangan, 2000
The objective of this study was to obtain fermentation process for producing l-lysine using two mutans of Corynebacterium glutamicum. The process used a low cost natural raw material molasses as a carbon source which underwent a special treatment ...
Budiatman Satiawihardja 1, Erliza Noor 2, Ahmad Haryo Oktamto 3   +2 more
doaj  

Heterologous plastoquinone production using a newly identified O2‐dependent cyanobacterial hydroxylase

The FEBS Journal, EarlyView.
In this study, we confirm that PlqH is the hydroxylase operating in plastoquinone biosynthesis in photosynthetic cyanobacteria (Cyanobacteriia). Our phylogenetic analyses demonstrate that cyanobacterial PlqH homologues originated from hydroxylases involved in ubiquinone biosynthesis in bacteria. Plastoquinone production in Escherichia coli was achieved
Morgane Roger‐Margueritat, Margot Beltran, Juliette Schnoebelen, Laura Flandrin, Wafa Rezali, Eline Michel, Sophie S. Abby, Fabien Pierrel   +7 more
wiley   +1 more source