Results 101 to 110 of about 107,677 (297)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

Green Cosmetics - Changing Young Consumer Preference and Reforming Cosmetic Industry

, 2019
Rachita Kapoor, Anurupa B. Singh, Richa Misra, U Aagerup, J Nilsson, P Andard, R Anderson, J Engledow, H Becker, S Anjana, D Bennett, B Ritz, D Cassady, K Lee, I Hertz-Picciotto, B, P, A Boztepe, M Cervellon, M Rinaldi, A Wernerfelt, Y Chen, H Christopher Gan, A Desore, S, V Dimitrova, G Teodoro, M Kaneva, D' Souza, C Taghian, M Lamb, P Peretiatko, R, E Fraj, E Martinez, Z Jin, K Hunter, A Junaid, R Nasreen, F Ahmed, U Kanchan, N Kumar, A Gupta, H Kaufmann, M Panni, Y Orphanidou, A Khan, M, S Kim, Y Seock, M Kothari P Pritam, P Kumar, M Laroche, J Bergeron, G Barbaro-Forleo, K Lee, A Lehriv, M Mati, B Puh, K Mathur, A Sharma, R Misra, D Singh, R Misra, S Singh, D Singh, G Nagra, R Gopal, P Oyewole, P Sangkumchaliang, W Huang, C Santos F Bruno, M Schuhwerk, R Lefkoff-Hagius, R Sharma, K Mehta, S Sharma, A Timothy, R Yazdanifard, M Vincent, R Yazdanifard, I Mercy, Yeon Kim, H Chung, J, Zeinab Seyed Saleki, S   +86 more
openalex   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Whole-Genome Sequencing and Genomic Features of Vagococcus sp. JNUCC 83 Isolated from Camellia japonica Flowers

Microbiology Research
Vagococcus species have been isolated from diverse environments, including aquatic, terrestrial, food-associated, and clinical sources; however, plant- and flower-associated representatives remain poorly characterized at the genomic level. In this study,
Kyung-A Hyun, Ji-Hyun Kim, Min Nyeong Ko, Chang-Gu Hyun   +3 more
doaj   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Structure Identification of Ganoderma lucidum Spore Polysaccharides and Their Antitumor Activity In Vivo

Molecules
Ganoderma lucidum spore powder, valued for its nutritional and medicinal properties, contains polysaccharides crucial for its efficacy. However, the complex structural nature of these polysaccharides necessitates further investigation to fully realize ...
Hui-Min Liu, Jun Cheng, Xiao-Yi Wang, Yan Jiang, Jia Ni, Yun Zhang, Wei Wang   +6 more
doaj   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Study of the Development of Color Cosmetics Package Design Reflecting Art Marketing [PDF]

, 2014
Jinyoung Kim
openalex   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source