Results 91 to 100 of about 194,869 (207)

Extranodal diffuse large B‐cell lymphoma: Clinical and molecular insights with survival outcomes from the multicenter EXPECT study

Cancer Communications, EarlyView.
Abstract Background Diffuse large B‐cell lymphoma (DLBCL) is the most common subtype of aggressive non‐Hodgkin's lymphoma with distinct clinical and molecular heterogeneity. DLBCL that arises in extranodal organs is particularly linked to poor prognosis. This study aimed to determine the clinical and molecular characteristics of extranodal involvement (
Si‐Yuan Chen, Peng‐Peng Xu, Ru Feng, Guo‐Hui Cui, Li Wang, Shu Cheng, Rong‐Ji Mu, Hui‐Lai Zhang, Xiao‐Lei Wei, Yong‐Ping Song, Kai‐Yang Ding, Li‐Hua Dong, Zun‐Min Zhu, Shen‐Miao Yang, Xin Wang, Ting‐Bo Liu, Jian‐Da Hu, Xiao‐Yun Zheng, Ou Bai, Jing‐Yan Xu, Liang Huang, Wei Sang, Ke‐Qian Shi, Fan Zhou, Fei Li, Ai‐Bin Liang, Hui Zhou, Si‐Guo Hao, Hong‐Hui Huang, Bin Xu, Wen‐Bin Qian, Cai‐Xia Li, Zhi‐Ming Li, Chong‐Yang Wu, Xiao‐Bo Wang, Wen‐Yu Shi, Shu‐Ye Wang, Yu‐Yang Tian, Xi Zhang, Ke‐Shu Zhou, Li‐Juan Cui, Hui Liu, Huo Tan, Qing Leng, Dong‐Lu Zhao, Ting Niu, Wei‐Li Zhao   +46 more
wiley   +1 more source

CTHRC1 is a Potential Prognostic Biomarker and Correlated with Macrophage Infiltration in Breast Cancer

International Journal of General Medicine, 2022
Background Tumor immune cell infiltration is closely associated with the occurrence and development of tumors. Collagen triple helix repeats containing 1 (CTHRC1), a regulator of collagen expression and cell migration, is involved in the metastasis and ...
Zejun Wang, Shichao Zhang, Chaochao Zheng, Kaide Xia, Liang-liang Sun, Xuejie Tang, Fulin Zhou, Y. Ouyang, Fuzhou Tang   +8 more
semanticscholar   +1 more source

Severity of effect considerations regarding the use of mutation as a toxicological endpoint for risk assessment: A report from the 8th International Workshop on Genotoxicity Testing (IWGT)

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Exposure levels without appreciable human health risk may be determined by dividing a point of departure on a dose–response curve (e.g., benchmark dose) by a composite adjustment factor (AF). An “effect severity” AF (ESAF) is employed in some regulatory contexts.
Barbara L. Parsons, Marc A. Beal, Kerry L. Dearfield, George R. Douglas, Min Gi, B. Bhaskar Gollapudi, Robert H. Heflich, Katsuyoshi Horibata, Michelle Kenyon, Alexandra S. Long, David P. Lovell, Anthony M. Lynch, Meagan B. Myers, Stefan Pfuhler, Alisa Vespa, Andreas Zeller, George E. Johnson, Paul A. White   +17 more
wiley   +1 more source

Mutational signatures in tumours induced by high and low energy radiation in Trp53 deficient mice. [PDF]

, 2020
Ionising radiation (IR) is a recognised carcinogen responsible for cancer development in patients previously treated using radiotherapy, and in individuals exposed as a result of accidents at nuclear energy plants.
Adams, Cassandra J, Adams, David, Alexandrov, Ludmil B, Balmain, Allan, Del Rosario, Reyno, Fredlund, Erik, Halliwill, Kyle D, Hirst, Gillian, Iyer, Vivek, Jen, Kuang-Yu, Mamunur, Rashid, Riva, Laura, Rose Li, Yun   +12 more
core   +1 more source

Germline pathogenic variants in HIC1 DNA binding domains are associated with familial serrated polyposis syndrome

International Journal of Cancer, EarlyView.
What's New? Serrated polyposis syndrome has been associated with an increased risk of colorectal cancer. HIC1 is a tumor suppressor gene commonly silenced in serrated polyps and several cancers. This study suggests HIC1 as a novel germline predisposition factor to serrated polyposis syndrome, with variants altering gene transcriptional regulation and ...
Xavier Domínguez‐Rovira, Coral Arnau‐Collell, Gemma Gonfaus‐Ortiz, Gemma Llargués‐Sistac, Jenifer Muñoz, Ainara Llopis, Yasmin Soares de Lima, Cristina Herrera‐Pariente, Leticia Moreira, Teresa Ocaña, Marcos Díaz‐Gay, Miriam Cuatrecasas, Sabela Carballal, Anael López‐Novo, Guerau Fernàndez, Antoni Castells, Luis Bujanda, Gabriel Capellà, Joaquín Cubiella, Daniel Rodríguez‐Alcalde, Laura Valle, Francesc Balaguer, Clara Ruiz‐Ponte, Laia Bonjoch, Sergi Castellví‐Bel   +24 more
wiley   +1 more source

Detecting protein variants by mass spectrometry: a comprehensive study in cancer cell-lines

Genome Medicine, 2017
Background Onco-proteogenomics aims to understand how changes in a cancer’s genome influences its proteome. One challenge in integrating these molecular data is the identification of aberrant protein products from mass-spectrometry (MS) datasets, as ...
Javier A. Alfaro, Alexandr Ignatchenko, Vladimir Ignatchenko, Ankit Sinha, Paul C. Boutros, Thomas Kislinger   +5 more
doaj   +1 more source

Effect of PTGES3 on the Prognosis and Immune Regulation in Lung Adenocarcinoma

Analytical Cellular Pathology, 2023
Background. PTGES3 is upregulated in multiple cancer types and promotes tumorigenesis and progression. However, the clinical outcome and immune regulation of PTGES3 in lung adenocarcinoma (LUAD) are not fully understood.
Wenyan Jiang, Qiong Wei, Haiqin Xie, Dandan Wu, Haiyan He, Xuedong Lv   +5 more
doaj   +1 more source

Effect of bet missense mutations on bromodomain function, inhibitor binding and stability [PDF]

, 2016
Lysine acetylation is an important epigenetic mark regulating gene transcription and chromatin structure. Acetylated lysine residues are specifically recognized by bromodomains, small protein interaction modules that read these modification in a ...
Alessandra, Pasquo, Chiaraluce, Roberta, Consalvi, Valerio, Cynthia, Tallant, Lori, Clorinda, Lori, Laura, Petrosino, Maria, Stefan, Knapp   +7 more
core   +2 more sources

Probing the Stability of Convolution Neural Networks and Support Vector Machines With Transmission Low Wavenumber Raman Spectroscopic Data

Journal of Raman Spectroscopy, EarlyView.
No spectral dataset is perfect, but how severely will imperfection cost you? This study finds that CNNs are more robust against spectral errors than SVMs, particularly with data that exhibits day‐to‐day calibration‐type errors. However, when no artefacts are present, the SVM produces the best model.
Mitchell Chalmers, Keith C. Gordon, Brendan McCane, Sara J. Fraser‐Miller   +3 more
wiley   +1 more source

QuaDMutEx: quadratic driver mutation explorer [PDF]

, 2017
Background Somatic mutations accumulate in human cells throughout life. Some may have no adverse consequences, but some of them may lead to cancer. A cancer genome is typically unstable, and thus more mutations can accumulate in the DNA of cancer cells ...
Arodz, Tomasz Jakub, Yahya, Bokhari
core   +1 more source