Results 91 to 100 of about 184,107 (180)

Predicting the functional impact of protein mutations: application to cancer genomics

Nucleic Acids Research, 2011
As large-scale re-sequencing of genomes reveals many protein mutations, especially in human cancer tissues, prediction of their likely functional impact becomes important practical goal.
B. Reva, Yevgeniy Antipin, C. Sander
semanticscholar   +1 more source

Mosaic variants of neurodevelopmental and mitochondrial genes in postmortem paraventricular thalamus in bipolar disorder detected by deep exome sequencing

Psychiatry and Clinical Neurosciences, EarlyView.
Aim The genetic architecture of bipolar disorder (BD) remains incompletely understood despite extensive genomic studies. Postzygotic mosaic variants have emerged as promising contributors to BD; however, the landscape of such variants in the BD brain has yet to be elucidated.
Masaki Nishioka, Zen‐ichi Tanei, Yuko Saito, Maho Morishima, Mizuki Hino, Kanako Mori, Atsuko Nagaoka, Risa Shishido, Rie Saito, Hideaki Kitamura, Akito Nagakura, Araki Kimura, Shuji Iritani, Kenichi Oshima, Akiyoshi Kakita, Yasuto Kunii, Shigeo Murayama, Tadafumi Kato   +17 more
wiley   +1 more source

Cosmovision as Cognitive Technology: The Case of Mesoamerican Medicinal Knowledge

Topics in Cognitive Science, EarlyView.
Abstract We examine the use of cognitive technologies in the acquisition and retention of botanical and medicinal knowledge. We focus on the Cruz‐Badianus codex, a 16th‐century Nahua (Aztec) herbarium which discusses the use of plants for a range of illnesses.
Johan De Smedt, Helen De Cruz
wiley   +1 more source

Genomic Evaluation of Canine Prostatic Carcinomas as a Model for the Human Disease: or ‘UC or not UC – that is the question’

Veterinary and Comparative Oncology, EarlyView.
ABSTRACT Spontaneous canine prostate cancer (PC) is widely considered a pertinent clinical model for the human disease. While over 95% of PC in men are adenocarcinomas, arising from prostatic glandular epithelium, it is increasingly recognised that many canine PC are of urothelial origin, arising within the prostatic urethra or ducts, or through ...
Rachael Thomas, Jennifer A. Luff, Allison N. Dickey, Megan N. Dillon, Isabella G. Livingston, Carter A. Schrag, Steven E. Suter, Matthew Breen   +7 more
wiley   +1 more source

Statistical method on nonrandom clustering with application to somatic mutations in cancer

BMC Bioinformatics, 2010
Background Human cancer is caused by the accumulation of tumor-specific mutations in oncogenes and tumor suppressors that confer a selective growth advantage to cells.
Rejto Paul A, Lunney Elizabeth A, Pavlicek Adam, Ye Jingjing, Teng Chi-Hse   +4 more
doaj   +1 more source

Exploring somatic mutations in cancer with the COSMIC database and analysis tools

, 2022

openalex   +1 more source

Immunophenotyping and Mutation Analysis of Canine Intestinal T‐Cell Lymphoma: A Comparative Pathological Study of Human Enteropathy‐Associated T‐Cell Lymphoma

Veterinary and Comparative Oncology, EarlyView.
ABSTRACT Human enteropathy‐associated T‐cell lymphoma (EATL) is a rare primary aggressive intestinal T‐cell lymphoma associated with celiac disease and is considered to be a neoplasm of intraepithelial lymphocytes (IELs) with an innate lymphoid cell (ILC)‐like immunophenotype. The lack of an animal model has delayed the elucidation of its pathogenesis.
Kazuhiro Kojima, James K. Chambers, Ko Nakashima, Kazumi Nibe, Kazuyuki Uchida   +4 more
wiley   +1 more source

Women in space: A review of known physiological adaptations and health perspectives

Experimental Physiology, EarlyView.
Abstract Exposure to the spaceflight environment causes adaptations in most human physiological systems, many of which are thought to affect women differently from men. Since only 11.5% of astronauts worldwide have been female, these issues are largely understudied.
Millie Hughes‐Fulford, Danielle J. Carroll, Heather C. M. Allaway, Bonnie J. Dunbar, Aenor J. Sawyer   +4 more
wiley   +1 more source

Genome-wide somatic mutation analysis of sinonasal adenocarcinoma with and without wood dust exposure

Genes and Environment
Background Sinonasal adenocarcinoma is a rare cancer, encompassing two different entities, the intestinal-type sinonasal adenocarcinoma (ITAC) and the non-intestinal-type sinonasal adenocarcinoma (non-ITAC). Occurrence of ITAC is strongly associated with
Lauri J. Sipilä, Riku Katainen, Mervi Aavikko, Janne Ravantti, Iikki Donner, Rainer Lehtonen, Ilmo Leivo, Henrik Wolff, Reetta Holmila, Kirsti Husgafvel-Pursiainen, Lauri A. Aaltonen   +10 more
doaj   +1 more source

Spaceborne and spaceborn: Physiological aspects of pregnancy and birth during interplanetary flight

Experimental Physiology, EarlyView.
Abstract Crewed interplanetary return missions that are on the planning horizon will take years, more than enough time for initiation and completion of a pregnancy. Pregnancy is viewed as a sequence of processes – fertilization, blastocyst formation, implantation, gastrulation, placentation, organogenesis, gross morphogenesis, birth and neonatal ...
Arun V. Holden
wiley   +1 more source