Results 91 to 100 of about 186,949 (193)

Spaceborne and spaceborn: Physiological aspects of pregnancy and birth during interplanetary flight

Experimental Physiology, EarlyView.
Abstract Crewed interplanetary return missions that are on the planning horizon will take years, more than enough time for initiation and completion of a pregnancy. Pregnancy is viewed as a sequence of processes – fertilization, blastocyst formation, implantation, gastrulation, placentation, organogenesis, gross morphogenesis, birth and neonatal ...
Arun V. Holden
wiley   +1 more source

Germline genetic variants were interactively associated with somatic alterations in gastric cancer

Cancer Medicine, 2018
Genome‐wide association studies have identified several germline variants in gastric cancer. Meanwhile, sequencing studies have characterized extensive somatic alterations that arise during gastric carcinogenesis.
Xu Zhang, Yuzhuo Wang, Tian Tian, Gangqiao Zhou, Guangfu Jin   +4 more
doaj   +1 more source

Clinical and genetic features of multiple primary tumours cohorts with a renal cell carcinoma: Implications for molecular genetic investigations

International Journal of Cancer, Volume 157, Issue 12, Page 2532-2543, 15 December 2025.
What's New? Current knowledge of the genetic architecture underlying the development of renal cell carcinoma‐related multiple primary tumours is limited. The authors comprehensively analysed the results of exome/genome sequencing cohorts including 534 patients to better define genotype–phenotype correlations.
Huairen Zhang, Bryndis Yngvadottir, Avgi Andreou, Yasemin Cole, Emma R. Woodward, James Whitworth, Eamonn R. Maher   +6 more
wiley   +1 more source

Predicting the functional impact of protein mutations: application to cancer genomics

Nucleic Acids Research, 2011
As large-scale re-sequencing of genomes reveals many protein mutations, especially in human cancer tissues, prediction of their likely functional impact becomes important practical goal.
B. Reva, Yevgeniy Antipin, C. Sander
semanticscholar   +1 more source

Genomic Evaluation of Canine Prostatic Carcinomas as a Model for the Human Disease: or ‘UC or not UC – that is the question’

Veterinary and Comparative Oncology, Volume 23, Issue 4, Page 528-548, December 2025.
ABSTRACT Spontaneous canine prostate cancer (PC) is widely considered a pertinent clinical model for the human disease. While over 95% of PC in men are adenocarcinomas, arising from prostatic glandular epithelium, it is increasingly recognised that many canine PC are of urothelial origin, arising within the prostatic urethra or ducts, or through ...
Rachael Thomas, Jennifer A. Luff, Allison N. Dickey, Megan N. Dillon, Isabella G. Livingston, Carter A. Schrag, Steven E. Suter, Matthew Breen   +7 more
wiley   +1 more source

Immunophenotyping and Mutation Analysis of Canine Intestinal T‐Cell Lymphoma: A Comparative Pathological Study of Human Enteropathy‐Associated T‐Cell Lymphoma

Veterinary and Comparative Oncology, Volume 23, Issue 4, Page 567-579, December 2025.
ABSTRACT Human enteropathy‐associated T‐cell lymphoma (EATL) is a rare primary aggressive intestinal T‐cell lymphoma associated with celiac disease and is considered to be a neoplasm of intraepithelial lymphocytes (IELs) with an innate lymphoid cell (ILC)‐like immunophenotype. The lack of an animal model has delayed the elucidation of its pathogenesis.
Kazuhiro Kojima, James K. Chambers, Ko Nakashima, Kazumi Nibe, Kazuyuki Uchida   +4 more
wiley   +1 more source

Statistical method on nonrandom clustering with application to somatic mutations in cancer

BMC Bioinformatics, 2010
Background Human cancer is caused by the accumulation of tumor-specific mutations in oncogenes and tumor suppressors that confer a selective growth advantage to cells.
Rejto Paul A, Lunney Elizabeth A, Pavlicek Adam, Ye Jingjing, Teng Chi-Hse   +4 more
doaj   +1 more source

Association of high‐dose radioactive iodine therapy with PPM1D‐mutated clonal hematopoiesis in older individuals

Molecular Oncology, Volume 19, Issue 11, Page 3079-3095, November 2025.
In thyroid cancer patients, high‐dose (≥7.4 GBq) radioactive iodine therapy (RAIT) was associated with a higher prevalence of clonal hematopoiesis (variant allele frequency >2%) in individuals aged ≥50 years (OR = 2.44). In silico analyses showed that truncating PPM1D mutations conferred a selective advantage under these conditions.
Jaeryuk Kim, Sungwoo Bae, Jaeyong Choi, Sun‐Wha Im, Bukyoung Cha, Gyeongseo Jung, Sun Wook Cho, Eul‐Ju Seo, Young Ah Lee, Jin Chul Paeng, Young Joo Park, Jong‐Il Kim   +11 more
wiley   +1 more source

EETs Reduction Contributes to Granulosa Cell Senescence and Endometriosis‐Associated Infertility via the PI3K/AKT/mTOR Signaling Pathway

Advanced Science, Volume 12, Issue 42, November 13, 2025.
1) 14, 15‐EET levels were decreased in ovarian granulosa cells, follicular fluid, peritoneal fluid from endometriosis patients. 2) EETs reduction in endometriosis follicular fluid aggravated granulosa cell senescence. 3) ROS reduced 14, 15‐EET levels by upregulating EPHX2 through a mechanism involving histone methylation modification.
Xiang Lin, Weijia Gu, Xiaomei Tong, Mengru Lai, Yi Zhang, Na Liu, Xiaoying Jin, Chao Li, Dong Huang, Feng Zhou, Yongdong Dai, Songying Zhang   +11 more
wiley   +1 more source

Genome-wide somatic mutation analysis of sinonasal adenocarcinoma with and without wood dust exposure

Genes and Environment
Background Sinonasal adenocarcinoma is a rare cancer, encompassing two different entities, the intestinal-type sinonasal adenocarcinoma (ITAC) and the non-intestinal-type sinonasal adenocarcinoma (non-ITAC). Occurrence of ITAC is strongly associated with
Lauri J. Sipilä, Riku Katainen, Mervi Aavikko, Janne Ravantti, Iikki Donner, Rainer Lehtonen, Ilmo Leivo, Henrik Wolff, Reetta Holmila, Kirsti Husgafvel-Pursiainen, Lauri A. Aaltonen   +10 more
doaj   +1 more source