Results 101 to 110 of about 186,949 (193)

Machine Learning–Driven Integration of Cancer Cell Phenotypes Predicts Cisplatin Sensitivity

Cancer Medicine, Volume 14, Issue 22, November 2025.
The CSP26G model, a predictor of cisplatin sensitivity, was developed using machine learning to integrate cancer cell phenotypes. This model accurately predicted sensitivity in vitro and the prognosis of patients with non‐small cell lung cancer. ABSTRACT Background Precision medicine has personalized anticancer therapies and has been considered ...
Haruki Ujiie, Tomoko Sakyo, Konomi Oya, Yuto Sugawara, Miyu Ota, Honami Yonezawa, Naoyuki Nishiya   +6 more
wiley   +1 more source

Organoid‐based two‐step drug screening for rapid identification of chemotherapy‐resistant oesophageal squamous cell carcinoma and alternative therapies

Clinical and Translational Medicine, Volume 15, Issue 11, November 2025.
Organoid‐based two‐step drug screening method can dynamically identify alternative sensitive drugs for resistant patients, providing theoretical support for the ‘repositioning’ of these drugs. This method addresses a critical unmet need for patients refractory to first‐line therapies by enabling timely identification of effective treatment alternatives.
Chen‐Ye Shao, Sheng Ju, Xin Tong, Kang Hu, Yu Li, Yi‐xian Zhu, Jian Yang, Chang Li, Yu‐feng Xie, Yuan Cui, Wei‐jun Deng, Cheng Ding, Song‐bing Qin, Jun Zhao   +13 more
wiley   +1 more source

Genetic variants linked to type 2 diabetes in CDKN1B and TCF7L2 influence survival outcomes in metastatic colorectal cancer

International Journal of Cancer, Volume 157, Issue 9, Page 1853-1863, 1 November 2025.
What's new? Multiple genetic polymorphisms characteristic of type 2 diabetes (T2D) have been associated with unfavorable prognostic outcomes in individuals with both T2D and metastatic colorectal cancer. This study evaluated the impact of T2D genetic polymorphisms on metastatic colon cancer prognosis in a cohort of non‐diabetic patients.
Raffaella Ruggiero, Alessandro Ottaiano, Madhura Tathode, Roberto Sirica, Annabella Di Mauro, Monica Ianniello, Nadia Petrillo, Massimiliano Berretta, Silvia Zappavigna, Amalia Luce, Michele Caraglia, Giovanni Savarese   +11 more
wiley   +1 more source

Chromosomal instability and genomic alterations in cholangiocarcinoma from Northeastern Thailand

The Journal of Pathology, Volume 267, Issue 3, Page 261-274, November 2025.
Abstract Cholangiocarcinoma (CCA) is a lethal cancer of the bile duct and is a major health concern in several parts of the world, including northeastern Thailand, where CCA incidence is the highest due to the endemic liver fluke Opisthorchis viverrini.
Raksawan Deenonpoe, Molly A Guscott, Sasithorn Watcharadetwittaya, Isabel L McNeill, Daniela Moralli, Nadeem Shaikh, Sarah E McClelland   +6 more
wiley   +1 more source

Tracing metastatic spread in pediatric solid tumors using copy number and targeted deep sequencing

The Journal of Pathology, Volume 267, Issue 3, Page 347-365, November 2025.
Abstract The most common cause of death in pediatric cancer patients is a treatment‐resistant tumor, compounded by metastatic spread, making surgery, radiation therapy, and chemotherapy unfeasible as curative treatment options. However, the mechanisms behind metastatic spread in pediatric tumors remain largely unexplored. We conducted whole‐genome copy
Natalie Andersson, Michele Ferro, Caroline Jansson, Subhayan Chattopadhyay, Jenny Karlsson, David Gisselsson   +5 more
wiley   +1 more source

Correlation Patterns of Muon Flux With Vertical Atmospheric Profiles: Insights From Monte Carlo Simulations

Journal of Geophysical Research: Space Physics, Volume 130, Issue 11, November 2025.
Abstract The production, attenuation, and absorption of secondary cosmic rays (SCR) are influenced by atmospheric parameters such as air pressure and temperature. To reliably correlate SCR flux measurements with atmospheric ionization driven by energetic particle precipitation, these dependencies must be quantified.
A. Al‐Qaaod, V. Pierrard, A. Winant, U. Stolzenberg, I. Ambrozova, M. Sommer, J. Slegl, J. Solc, A. Gkikoudi, A. G. Georgakilas, A. Papayannis, F. S. Krasniqi   +11 more
wiley   +1 more source

Sam-Sam Association Between EphA2 and SASH1: In Silico Studies of Cancer-Linked Mutations

Molecules
Recently, SASH1 has emerged as a novel protein interactor of a few Eph tyrosine kinase receptors like EphA2. These interactions involve the first N-terminal Sam (sterile alpha motif) domain of SASH1 (SASH1-Sam1) and the Sam domain of Eph receptors ...
Marian Vincenzi, Flavia Anna Mercurio, Ida Autiero, Marilisa Leone   +3 more
doaj   +1 more source

Genome‐Wide Screening in Haploid Stem Cells Reveals Synthetic Lethality Targeting MLH1 and TP53 Deficient Tumours

Cell Proliferation, Volume 58, Issue 11, November 2025.
To identify genetic events that can lead to tumour death once either MLH1 or TP53 is mutated, a genome‐wide genetic screening was performed, uncovering a list of putative hits. Synthetic lethal interactions were validated either genetically or chemically by using small molecules that inhibit these genes either in vitro and in vivo.
Rivki Cashman, Guy Haim‐Abadi, Elyad Lezmi, Hagit Philip, Jonathan Nissenbaum, Ruth Viner‐Breuer, Chen Kozulin, Tamar Golan‐Lev, Aseel Gadban, Shiri Spinner‐Potesky, Ofra Yanuka, Oded Kopper, Nissim Benvenisty   +12 more
wiley   +1 more source

A somatic multiple myeloma mutation unravels a mechanism of oligomerization‐mediated product inhibition in GGPPS

The FEBS Journal, Volume 292, Issue 21, Page 5802-5817, November 2025.
Geranylgeranyl diphosphate synthase (GGPPS) plays a key role in multiple myeloma biology. Using crystallography, mass spectrometry, and fluorescence spectroscopy, this study shows that a somatic multiple myeloma cell line mutation destabilizes inter‐dimer interactions, resulting in increased GGPPS activity by facilitating product releas.
Ruba Yehia, Jasmína Mária Portašiková, Rut Mor Yosef, Benny Da'adoosh, Alan Kádek, Petr Man, Moshe Giladi, Yoni Haitin   +7 more
wiley   +1 more source

MYC Point Mutations in Cancer: A Reboot and a Sequel. [PDF]

Clin Cancer Res
De Luca D, Munafò C, Lorenzi L, Cucco F.   +3 more
europepmc   +1 more source