Results 111 to 120 of about 184,107 (180)

Analysis of IDH1 and IDH2 mutations as causes of the hypermethylator phenotype in colorectal cancer

The Journal of Pathology, Volume 267, Issue 1, Page 40-55, September 2025.
Abstract The CpG island methylator phenotype (CIMP) occurs in many colorectal cancers (CRCs). CIMP is closely associated with global hypermethylation and tends to occur in proximal tumours with microsatellite instability (MSI), but its origins have been obscure.
Joseph C Ward, Melissa Morgan, James Wood, Connor Woolley, Albert Antao Nobre de Menezes, Alina Finch, Kitty Sherwood, Qiwen Huang, Chloe S Henry, Juan Fernández‐Tajes, Ignacio Soriano, Steve Thorn, Isabelle Legge, James McCullagh, David Kerr, Rachel Kerr, Rahul K Hejmadi, Mark J Arends, The S:CORT Consortium, Richard Adams, Simon Bach, Andrew Beggs, Louise Brown, Francesca Buffa, Jean‐Baptiste Cazier, Enric Domingo, Andrew Blake, Che‐Hsi Wu, Ekaterina Chatzpili, Susan Richman, Philip Dunne, Paul Harkin, Geoff Higgins, Jim Hill, Chris Holmes, Denis Horgan, Rick Kaplan, Richard Kennedy, Mark Lawler, Simon Leedham, Ultan McDermott, Gillies McKenna, Gary Middleton, Dion Morton, Graeme Murray, Philip Quirke, Manuel Salto‐Tellez, Les Samuel, Anna Schuh, David Sebag‐Montefiore, Matt Seymour, Ricky Sharma, Richard Sullivan, Ian Tomlinson, Nicholas West, Richard Wilson, Enric Domingo, Timothy Maughan, Chiara Bardella, Ian Tomlinson   +59 more
wiley   +1 more source

Revolutionizing Veterinary Medicine: The Role of Nanoparticles in Advancing Animal Health, Nutrition and Disease Management

Veterinary Medicine and Science, Volume 11, Issue 5, September 2025.
Nanoparticles are transforming animal care by enhancing nutrition, drug delivery and disease prevention. This study highlights their role in improving nutrient absorption in livestock, facilitating targeted drug delivery and boosting vaccine efficacy. Additionally, nanoparticles effectively reduce harmful mycotoxins in animal feeds, promoting overall ...
Mohsen Kazemi
wiley   +1 more source

Polarity Gene PARD6B Promotes Tumor Growth of Colorectal Cancer via Increasing MYC Expression

Cancer Science, Volume 116, Issue 9, Page 2507-2522, September 2025.
Partitioning Defective 6B (PARD6B), a polarity gene, functions as a scaffold node for the Par protein complex. In this study, we showed that highly expressed PARD6B could promote CRC growth by upregulating MYC expression while suppressing miR‐34c expression.
Kosuke Hirose, Takaaki Masuda, Hajime Otsu, Taro Tobo, Kiyotaka Hosoda, Tadashi Abe, Yusuke Nakano, Masahiro Hashimoto, Takanari Tatsumi, Tomohiko Ikehara, Takashi Ofuchi, Shinsaku Itoyama, Yuki Ando, Yasuo Tsuda, Yusuke Yonemura, Keishi Sugimachi, Eiji Oki, Tomoharu Yoshizumi, Koshi Mimori   +18 more
wiley   +1 more source

Unusual Morphologic Presentation of Perineural Spread From Cutaneous Squamous Cell Carcinoma: Diagnosis Aided by Comprehensive Molecular Analysis and Machine Learning

Journal of Cutaneous Pathology, Volume 52, Issue 9, Page 568-573, September 2025.
ABSTRACT Neoplasms of unknown primary frequently pose a diagnostic challenge due to their nonspecific morphological and immunohistochemical features. Definitive classification of these neoplasms has a profound impact on treatment decisions. Mutational and gene expression profiling can provide diagnostic and prognostic information in these challenging ...
Madhurya Ramineni, Hassan Ghani, Bruce R. Smoller, Rajnish Bharadwaj   +3 more
wiley   +1 more source

Current Evidences and Future Perspectives in the Management of Metastatic Non‐Clear Cell Renal Cell Carcinoma

International Journal of Urology, Volume 32, Issue 9, Page 1118-1128, September 2025.
ABSTRACT Renal cell carcinoma is a heterogeneous disease with diverse phenotypes. Renal cell carcinoma classification is based on morphological and molecular characteristics and falls into 2 main categories: clear cell renal cell carcinoma and non‐clear cell renal cell carcinoma.
Shotaro Nakanishi, Junichi Inokuchi
wiley   +1 more source

Evaluating Malignant Potential of Gastric Adenomas: The Role of Endoscopic Features and Genetic Alterations

Journal of Gastroenterology and Hepatology, Volume 40, Issue 9, Page 2282-2289, September 2025.
ABSTRACT Background and Aim There is no “gold standard” treatment for gastric adenomas due to uncertainty about their malignant potential. We wanted to understand better the factors contributing to their transformation into malignant tumors by analyzing their long‐term development, including endoscopic observations and genetic abnormalities.
Takeshi Ishida, Tatsuya Yamaguchi, Takashi Yoshida, Shoji Kobayashi, Toru Kuno, Shinya Takaoka, Yuko Aonuma, Satoshi Kawakami, Masaru Muraoka, Yuichiro Suzuki, Mitsuaki Sato, Shinichi Takano, Shinya Maekawa, Nobuyuki Enomoto   +13 more
wiley   +1 more source

COSMIC Database and Structural Modeling Analysis of CYP2D6 Mutations in Human Cancers [PDF]

Kennedy Kuchinski, N. W. King, Julia Driggers, Kylie Lawson, Martin Vo, Shayne Skrtic, Connor Slattery, Rebecca Lane, Emma Simone, Stephen A. Mills, Wilber Escorcia, Hanna N. Wetzel   +11 more
openalex   +1 more source

Regulation of DNA repair gene expression by PRMT5. [PDF]

MicroPubl Biol
Bliss H, Bouley RA, Petreaca RC.
europepmc   +1 more source

Prevalence and impact of molecular variation in the three-prime repair exonuclease 1 TREX1 and its implications for oncology. [PDF]

Hum Genomics
Shekfeh M, Konaté MM, Krushkal J.
europepmc   +1 more source

Whole genome sequencing revealed esophageal squamous cell carcinoma related biomarkers. [PDF]

PLoS One
Li M, Li L, Wang X, Zhao Y, Du P, Wang W, Wang Z, Wang Y, Sheng Y, Gu M, Jia X.   +10 more
europepmc   +1 more source