Results 111 to 120 of about 280,610 (238)
Network-based stratification of tumor mutations. [PDF]
, 2013 Many forms of cancer have multiple subtypes with different causes and clinical outcomes. Somatic tumor genome sequences provide a rich new source of data for uncovering these subtypes but have proven difficult to compare, as two tumors rarely share the ...
Carter, Hannah +4 more
core +3 more sources
Detecting protein variants by mass spectrometry: a comprehensive study in cancer cell-lines
Genome Medicine, 2017 Background Onco-proteogenomics aims to understand how changes in a cancer’s genome influences its proteome. One challenge in integrating these molecular data is the identification of aberrant protein products from mass-spectrometry (MS) datasets, as ...
Javier A. Alfaro +5 more
doaj +1 more source
Influence of different factors on survival of patients with colorectal cancer [PDF]
arXiv, 2022 Colorectal cancer refers to the cancer from the dentate line to the junction of rectosigmoid colon, which is one of the most common malignant tumors of the digestive tract. The treatment of colorectal cancer is controversial, so understanding the risk factors and survival factors of colorectal cancer is of great significance for the diagnosis of ...
arxiv
Prediction of Hereditary Cancers Using Neural Networks [PDF]
arXiv, 2021 Family history is a major risk factor for many types of cancer. Mendelian risk prediction models translate family histories into cancer risk predictions based on knowledge of cancer susceptibility genes. These models are widely used in clinical practice to help identify high-risk individuals.
arxiv
A Cancer Biotherapy Resource [PDF]
arXiv, 2015 Cancer Biotherapy (CB), as opposed to cancer chemotherapy, is the use of macromolecular, biological agents instead of organic chemicals or drugs to treat cancer. Biological agents usually have higher selectivity and have less toxic side effects than chemical agents. The I.S.B.T.C., being the only major information database for CB, seems lacking in some
arxiv
Prediction of cancer driver genes and mutations: the potential of integrative computational frameworks [PDF]
arXiv, 2023 The vast amount of sequencing data presently available allow the scientific community to explore a range of genetic variables that may drive and progress cancer. A myriad of predictive tools has been proposed, allowing researchers and clinicians to compare and prioritize driver genes and mutations and their relative pathogenicity.
arxiv
Mutant p53R270H drives altered metabolism and increased invasion in pancreatic ductal adenocarcinoma [PDF]
, 2018 Pancreatic cancer is characterized by nearly universal activating mutations in KRAS. Among other somatic mutations, TP53 is mutated in more than 75% of human pancreatic tumors.
Daylan, Ayse Ece Cali +20 more
core +1 more source
ChemBioChem, EarlyView.This work deals with intracellular effects of cell‐permeable CaaX‐peptides, designed to influence prenylated proteins like KRas. The results show that after CaaX‐1 treatment, not only KRas expression and signaling are specifically altered in mutated pancreatic cancer cells, but also plasma membrane localization of KRas is affected.
Merlin Klußmann +2 more
wiley +1 more source
Using data mining techniques for diagnosis and prognosis of cancer disease [PDF]
arXiv, 2012 Breast cancer is one of the leading cancers for women in developed countries including India. It is the second most common cause of cancer death in women. The high incidence of breast cancer in women has increased significantly in the last years. In this paper we have discussed various data mining approaches that have been utilized for breast cancer ...
arxiv
Effect of bet missense mutations on bromodomain function, inhibitor binding and stability [PDF]
, 2016 Lysine acetylation is an important epigenetic mark regulating gene transcription and chromatin structure. Acetylated lysine residues are specifically recognized by bromodomains, small protein interaction modules that read these modification in a ...
Alessandra, Pasquo +7 more
core +2 more sources