Results 111 to 120 of about 194,869 (207)

Current Evidences and Future Perspectives in the Management of Metastatic Non‐Clear Cell Renal Cell Carcinoma

International Journal of Urology, EarlyView.
ABSTRACT Renal cell carcinoma is a heterogeneous disease with diverse phenotypes. Renal cell carcinoma classification is based on morphological and molecular characteristics and falls into 2 main categories: clear cell renal cell carcinoma and non‐clear cell renal cell carcinoma.
Shotaro Nakanishi, Junichi Inokuchi
wiley   +1 more source

Predicting the functional impact of protein mutations: application to cancer genomics

Nucleic Acids Research, 2011
As large-scale re-sequencing of genomes reveals many protein mutations, especially in human cancer tissues, prediction of their likely functional impact becomes important practical goal.
B. Reva, Yevgeniy Antipin, C. Sander
semanticscholar   +1 more source

Evaluating Malignant Potential of Gastric Adenomas: The Role of Endoscopic Features and Genetic Alterations

Journal of Gastroenterology and Hepatology, EarlyView.
ABSTRACT Background and Aim There is no “gold standard” treatment for gastric adenomas due to uncertainty about their malignant potential. We wanted to understand better the factors contributing to their transformation into malignant tumors by analyzing their long‐term development, including endoscopic observations and genetic abnormalities.
Takeshi Ishida, Tatsuya Yamaguchi, Takashi Yoshida, Shoji Kobayashi, Toru Kuno, Shinya Takaoka, Yuko Aonuma, Satoshi Kawakami, Masaru Muraoka, Yuichiro Suzuki, Mitsuaki Sato, Shinichi Takano, Shinya Maekawa, Nobuyuki Enomoto   +13 more
wiley   +1 more source

Cosmovision as Cognitive Technology: The Case of Mesoamerican Medicinal Knowledge

Topics in Cognitive Science, EarlyView.
Abstract We examine the use of cognitive technologies in the acquisition and retention of botanical and medicinal knowledge. We focus on the Cruz‐Badianus codex, a 16th‐century Nahua (Aztec) herbarium which discusses the use of plants for a range of illnesses.
Johan De Smedt, Helen De Cruz
wiley   +1 more source

Expanding the Spectrum of Canine Diffuse Large B‐Cell Lymphoma Genetic Aberrations Through Whole Genome Sequencing Analysis

Veterinary and Comparative Oncology, EarlyView.
ABSTRACT Diffuse large B‐cell lymphoma (DLBCL) is one of the most prevalent haematological malignancies in both humans and dogs, characterised in both species by significant clinical heterogeneity and limited prognostic predictability. With the introduction of next‐generation sequencing (NGS) technologies in veterinary medicine over the past decade ...
Antonella Fanelli, Eugenio Mazzone, Diana Giannuzzi, Laura Marconato, Luca Aresu   +4 more
wiley   +1 more source

Statistical method on nonrandom clustering with application to somatic mutations in cancer

BMC Bioinformatics, 2010
Background Human cancer is caused by the accumulation of tumor-specific mutations in oncogenes and tumor suppressors that confer a selective growth advantage to cells.
Rejto Paul A, Lunney Elizabeth A, Pavlicek Adam, Ye Jingjing, Teng Chi-Hse   +4 more
doaj   +1 more source

Women in space: A review of known physiological adaptations and health perspectives

Experimental Physiology, EarlyView.
Abstract Exposure to the spaceflight environment causes adaptations in most human physiological systems, many of which are thought to affect women differently from men. Since only 11.5% of astronauts worldwide have been female, these issues are largely understudied.
Millie Hughes‐Fulford, Danielle J. Carroll, Heather C. M. Allaway, Bonnie J. Dunbar, Aenor J. Sawyer   +4 more
wiley   +1 more source

Spaceborne and spaceborn: Physiological aspects of pregnancy and birth during interplanetary flight

Experimental Physiology, EarlyView.
Abstract Crewed interplanetary return missions that are on the planning horizon will take years, more than enough time for initiation and completion of a pregnancy. Pregnancy is viewed as a sequence of processes – fertilization, blastocyst formation, implantation, gastrulation, placentation, organogenesis, gross morphogenesis, birth and neonatal ...
Arun V. Holden
wiley   +1 more source

Systematic analysis of the Hippo pathway organization and oncogenic alteration in evolution. [PDF]

, 2020
The Hippo pathway is a central regulator of organ size and a key tumor suppressor via coordinating cell proliferation and death. Initially discovered in Drosophila, the Hippo pathway has been implicated as an evolutionarily conserved pathway in mammals ...
Chen, Yuxuan, Chuc, Kimberly, Han, Han, Seo, Gayoung, Vargas, Rebecca Elizabeth, Wang, Wenqi, Yang, Bing, Zhao, Huabin   +7 more
core  

Integrated genomic and transcriptomic analyses of radiation-induced malignancies [PDF]

, 2016
Cancer is a genetic disease caused by an unregulated expansion of a clone of cells (Sompayrac, 2004). The genetic abnormalities in cancer are the consequences of defective DNA replication, repair, maintenance, and modification, genetic background, and ...
Lee, Yong Eun
core   +1 more source