Results 111 to 120 of about 102,505 (175)

A first RDF implementation of the COSMIC database on mutations in cancer

, 2012
Achille Zappa, Paolo Romano
openalex   +3 more sources

Circulating Tumour DNA in Patients With EGFR‐Mutated Non‐Small‐Cell Lung Cancer and Early Disease Progression After First‐Line Osimertinib Treatment: The ELUCIDATOR Multicentre Prospective Observational Study

Cancer Medicine, Volume 14, Issue 7, April 2025.
ABSTRACT Background Osimertinib is the standard therapy for patients with chemotherapy‐naive advanced non‐small‐cell lung cancer (NSCLC) harbouring sensitising epidermal growth factor receptor (EGFR) mutations. However, some patients treated with osimertinib experience progressive disease (PD).
Akihiro Tamiya, Yasuyuki Mizumori, Mitsuo Osuga, Shun‐ichi Isa, Yoshihiko Taniguchi, Keiichi Nakamura, Daijiro Harada, Tsutomu Shinohara, Hidetoshi Yanai, Katsumi Nakatomi, Masahide Oki, Masahide Mori, Tomohito Kuwako, Koji Yamazaki, Atsuhisa Tamura, Masahiko Ando, Yasuhiro Koh   +16 more
wiley   +1 more source

The Phenolic Signature of Psidium cattleianum Fruits and Leaves Modulates TRPV1 and TRPA1 Transient Receptor Potential Channels: A Metabolomics, In Vitro, and In Silico Study

Food Science &Nutrition, Volume 13, Issue 4, April 2025.
An untargeted metabolomics study was performed to find the encompassed phytochemicals in the fruit and leaf extract of Psidium cattleianum. This enabled the annotation of 469 compounds belonging to different phenolic subclasses, with a predominance of flavonoids and phenolics.
Leilei Zhang, Fabio Arturo Iannotti, Fatema R. Saber, Reem K. Arafa, Aniello Schiano Moriello, Rasha A. Rasle, Anton Soria‐Lopez, Sara G. Abd EL‐Gawwad, Gabriele Rocchetti, Paz Otero, Łukasz Kulinowski, Krystyna Skalicka‐Woźniak, Luigi Lucini, Jesus Simal‐Gandara   +13 more
wiley   +1 more source

TP53 deletion as an MRD‐dependent risk factor in childhood B‐ALL: A post hoc analysis from a prospective cohort

HemaSphere, Volume 9, Issue 4, April 2025.
Abstract The effect of TP53 alterations on childhood B‐cell acute lymphoblastic leukemia (B‐ALL) remains unclear. To investigate the prognostic value of TP53 deletion (TP53del) and TP53 mutation (TP53mut), this post hoc study used fluorescence in situ hybridization test to detect TP53del in 907 newly diagnosed B‐ALL patients from a prospective cohort ...
Yangyang Gao, Jun Li, Ning Wang, Wenbin An, Zixi Yin, Junxia Wang, Xia Chen, Yumei Chen, Ye Guo, Wenyu Yang, Li Zhang, Yao Zou, Xiaojuan Chen, Xiaofan Zhu   +13 more
wiley   +1 more source

Long non-coding RNA FAM87A is associated with overall survival and promotes cell migration and invasion in gastric cancer

Frontiers in Oncology
BackgroundThe role of long non-coding RNAs (lncRNAs) in the invasion and metastasis of gastric cancer remains largely unclear.MethodsIntegrating transcriptome data from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases ...
Xue Jiang, Xue Jiang, Xiaobin Wu, Manjiao Lu, Wenna Fan, Jing Song, Fangzhou Song   +6 more
doaj   +1 more source

Exploiting NRF2‐ARE pathway activation in papillary renal cell carcinoma

International Journal of Cancer, Volume 156, Issue 7, Page 1457-1469, 1 April 2025.
What's new? There are no targeted treatments available yet for papillary renal cell carcinoma (pRCC). Here, the authors investigate the NRF2‐ARE pathway as a possible source of therapeutic targets. The NRF2‐ARE pathway helps the cell detect and respond to increases in oxidative stress.
Silvia Angori, Harini Lakshminarayanan, Amir Banaei‐Esfahani, Katharina Mühlbauer, Hella Anna Bolck, Olli Kallioniemi, Vilja Pietiäinen, Peter Schraml, Holger Moch   +8 more
wiley   +1 more source

Role of TP53 Mutations and EGFR Amplification in Risk Stratification of Early‐Stage EGFR‐Mutated Non‐Small Cell Lung Cancer With Immunohistochemistry as a Surrogate Marker

Thoracic Cancer, Volume 16, Issue 7, April 2025.
Specific TP53 mutations and epidermal growth factor receptor (EGFR) amplification are associated with worse prognosis in early‐stage EGFR‐mutated non‐small cell lung cancer (NSCLC). Immunohistochemistry (IHC) (p53, EGFR) correlates with genetic alterations, providing a practical surrogate marker for risk stratification.
Meejeong Kim, Gyeong Sin Park, Kyo Young Lee, Seok Whan Moon, Yeoun Eun Sung   +4 more
wiley   +1 more source

Genetic profiling of rat gliomas and cardiac schwannomas from life-time radiofrequency radiation exposure study using a targeted next-generation sequencing gene panel.

PLoS ONE
The cancer hazard associated with lifetime exposure to radiofrequency radiation (RFR) was examined in Sprague Dawley (SD) rats at the Ramazzini Institute (RI), Italy. There were increased incidences of gliomas and cardiac schwannomas.
Ashley M Brooks, Andrea Vornoli, Ramesh C Kovi, Thai Vu T Ton, Miaofei Xu, Ahmed Mashal, Eva Tibaldi, Federica Gnudi, Jian-Liang Li, Robert C Sills, John R Bucher, Daniele Mandrioli, Fiorella Belpoggi, Arun R Pandiri   +13 more
doaj   +1 more source

EpigenPlot: An interactive web platform for DNA methylation‐based biomarker and drug target discovery in colorectal cancer

British Journal of Pharmacology, Volume 182, Issue 7, Page 1452-1465, April 2025.
Abstract Background and Purpose Genome‐wide methylation studies have significantly advanced our understanding of colorectal adenocarcinoma progression and biomarker discovery. Aberrant DNA methylation plays a crucial role in gene expression regulation during cancer transformation, highlighting the need to identify differentially methylated regions ...
Dalma Müller, Balázs Győrffy
wiley   +1 more source

Predictive Modeling of Novel Somatic Mutation Impacts on Cancer Prognosis: A Machine Learning Approach Using the COSMIC Database [PDF]

Masab Mansoor
openalex   +1 more source