Somatic Variations in Cervical Cancers in Indian Patients. [PDF]
PLoS ONE, 2016 There are very few reports that describe the mutational landscape of cervical cancer, one of the leading cancers in Indian women. The aim of the present study was to investigate the somatic mutations that occur in cervical cancer.
Poulami Das +7 more
doaj +1 more source
SomInaClust: detection of cancer genes based on somatic mutation patterns of inactivation and clustering [PDF]
, 2015 Background: With the advances in high throughput technologies, increasing amounts of cancer somatic mutation data are being generated and made available.
Fierro Gutierrez, Ana Carolina Elisa +3 more
core +2 more sources
Utilizing Protein Structure to Identify Non-Random Somatic Mutations [PDF]
, 2013 Motivation: Human cancer is caused by the accumulation of somatic mutations in tumor suppressors and oncogenes within the genome. In the case of oncogenes, recent theory suggests that there are only a few key "driver" mutations responsible for ...
Cheng, Yuwei +4 more
core +2 more sources
Profiling the interactome of protein kinase C ζ by proteomics and bioinformatics
Proteome Science, 2018 Background Protein kinase C ζ (PKCζ), an isoform of the atypical protein kinase C, is a pivotal regulator in cancer. However, the molecular and cellular mechanisms whereby PKCζ regulates tumorigenesis and metastasis are still not fully understood.
Chunyu Hou +6 more
doaj +1 more source
Frontiers in Oncology, 2023 BackgroundNext-generation sequencing (NGS) panels for mature B-cell neoplasms (MBNs) are widely applied clinically but have yet to be routinely used in a manner that is suitable for subtype differential diagnosis.
Yafei Mu +27 more
doaj +1 more source
Comparative study of the evolution of human cancer gene duplications across fish [PDF]
arXiv, 2021 Comparative studies of cancer-related genes allow us to gain novel information about the evolution and function of these genes, but also to understand cancer as a driving force in biological systems and species life histories. So far, comparative studies of cancer genes have focused on mammals.
arxiv
Identification of novel therapeutic targets in the PI3K/AKT/mTOR pathway in hepatocellular carcinoma using targeted next generation sequencing. [PDF]
, 2014 Understanding genetic aberrations in cancer leads to discovery of new targets for cancer therapies. The genomic landscape of hepatocellular carcinoma (HCC) has not been fully described. Therefore, patients with refractory advanced/metastatic HCC referred
Janku, Filip +4 more
core +3 more sources
Human Genomics, 2023 Mitogen-activated protein kinases 1 and 3 (MAPK1 and MAPK3), also called extracellular regulated kinases (ERK2 and ERK1), are serine/threonine kinase activated downstream by the Ras/Raf/MEK/ERK signal transduction cascade that regulates a variety of ...
Maria Petrosino +7 more
semanticscholar +1 more source
Sensor technologies in cancer research for new directions in diagnosis and treatment: and exploratory analysis [PDF]
arXiv, 2022 The goal of this study is an exploratory analysis concerning main sensor technologies applied in cancer research to detect new directions in diagnosis and treatments. The study focused on types of cancer having a high incidence and mortality worldwide: breast, lung, colorectal and prostate.
arxiv
Pockets as structural descriptors of EGFR kinase conformations [PDF]
, 2017 Epidermal Growth Factor Receptor (EGFR), a tyrosine kinase receptor, is one of the main tumor markers in different types of cancers. The kinase native state is mainly composed of two populations of conformers: active and inactive.
Barletta Roldan, Patricio German +4 more
core +1 more source