Results 61 to 70 of about 205,622 (234)

Mutant p53R270H drives altered metabolism and increased invasion in pancreatic ductal adenocarcinoma [PDF]

, 2018
Pancreatic cancer is characterized by nearly universal activating mutations in KRAS. Among other somatic mutations, TP53 is mutated in more than 75% of human pancreatic tumors.
Daylan, Ayse Ece Cali, Del Vecchio, Annachiara, Espinoza, Carlos, Fabo, Tania, Fearon, Eric R., Feng, Ying, Galbán, Stefanie, Halbrook, Christopher J., Karim, Saadia A., Kovalenko, Ilya, Kremer, Daniel M., Kumar-Sinha, Chandan, Lee, Ho-Joon, Ljungman, Mats, Lyssiotis, Costas A., Magnuson, Brian, Morton, Jennifer P., Pasca di Magliano, Marina, Schofield, Heather K., Yan, Wei, Zeller, Jörg   +20 more
core   +1 more source

Protein Tyrosine Phosphatase Non-Receptor 11 (PTPN11/Shp2) as a Driver Oncogene and a Novel Therapeutic Target in Non-Small Cell Lung Cancer (NSCLC)

International Journal of Molecular Sciences, 2023
PTPN11 encodes the SHP2 protein tyrosine phosphatase that activates the mitogen-activated protein kinase (MAPK) pathway upstream of KRAS and MEK. PTPN11/Shp2 somatic mutations occur frequently in Juvenile myelomonocytic leukaemia (JMML); however, the ...
Cathy E. Richards, Yasir Y. Elamin, A. Carr, K. Gately, S. Rafee, M. Cremona, E. Hanrahan, Robert Smyth, Daniel J Ryan, R. Morgan, Susan A. Kennedy, L. Hudson, J. Fay, K. O'Byrne, B. Hennessy, S. Toomey   +15 more
semanticscholar   +1 more source

Mutational landscape differences between young-onset and older-onset breast cancer patients

BMC Cancer, 2020
Background The incidence of breast cancer among young women (aged ≤40 years) has increased in North America and Europe. Fewer than 10% of cases among young women are attributable to inherited BRCA1 or BRCA2 mutations, suggesting an important role for ...
Nicole E. Mealey, Dylan E. O’Sullivan, Joy Pader, Yibing Ruan, Edwin Wang, May Lynn Quan, Darren R. Brenner   +6 more
doaj   +1 more source

Atmospheric Consequences of Cosmic Ray Variability in the Extragalactic Shock Model II: Revised ionization levels and their consequences

, 2010
It has been suggested that galactic shock asymmetry induced by our galaxy's infall toward the Virgo Cluster may be a source of periodicity in cosmic ray exposure as the solar system oscillates perpendicular to the galactic plane.
Adrian L. Melott, Aguirre, Alpen, Atri, Bancroft, Binney, Björn, Blaustein, Boucher, Brian C. Thomas, Cornette, Davidson, Dimitra Atri, Djemil, Ejzak, Foukal, Gehrels, Gies, Graham W. Wilson, Harfoot, Hatch, Häder, Jagger, Juckett, Juckett, Kiesecker, Lieberman, Lockwood, Madronich, McCallum, Medvedev, Melott, Melott, Melott, Melott, Melott, Michael J. Murray, Mikhail V. Medvedev, Natarajan, Overholt, Pukkala, Rohde, Ruderman, Scherer, Shaffer, Solanki, Svensmark, Tevini, Thomas, Thomas, Thomas   +50 more
core   +1 more source

The Landscape of Long Non-Coding RNA Dysregulation and Clinical Relevance in Muscle Invasive Bladder Urothelial Carcinoma. [PDF]

, 2019
Bladder cancer is one of the most common cancers in the United States, but few advancements in treatment options have occurred in the past few decades.
Chang, Eric Y, Chu, Megan, High, Rachel A, Li, Wei Tse, Ongkeko, Weg M, Shen, Haotian, Wang-Rodriguez, Jessica, Wong, Lindsay M   +7 more
core   +1 more source

The complex impact of cancer-related missense mutations on the stability and on the biophysical and biochemical properties of MAPK1 and MAPK3 somatic variants

Human Genomics, 2023
Mitogen-activated protein kinases 1 and 3 (MAPK1 and MAPK3), also called extracellular regulated kinases (ERK2 and ERK1), are serine/threonine kinase activated downstream by the Ras/Raf/MEK/ERK signal transduction cascade that regulates a variety of ...
Maria Petrosino, L. Novak, A. Pasquo, Paola Turina, E. Capriotti, V. Minicozzi, V. Consalvi, R. Chiaraluce   +7 more
semanticscholar   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

New Lung Cancer Panel for High-Throughput Targeted Resequencing [PDF]

Genomics & Informatics, 2014
We present a new next-generation sequencing-based method to identify somatic mutations of lung cancer. It is a comprehensive mutation profiling protocol to detect somatic mutations in 30 genes found frequently in lung adenocarcinoma.
Eun-Hye Kim, Sunghoon Lee, Jongsun Park, Kyusang Lee, Jong Bhak, Byung Chul Kim   +5 more
doaj   +1 more source

Biological implications of high-energy cosmic ray induced muon flux in the extragalactic shock model

, 2011
A ~ 62 My periodicity in fossil biodiversity has been observed in independent studies of paleontology databases over ~0.5Gy. The period and phase of this biodiversity cycle coincides with the oscillation of our solar system normal to the galactic disk ...
Adrian L. Melott, Alpen, Arens, Atri, Atri, Bailer-Jones, Chen, Cornette, Cucinotta, Dimitra Atri, Ferrari, Feulner, Gies, Groom, Hebbeker, Karam, Kirkby, Lieberman, McNulty, Medvedev, Melott, Melott, Melott, Melott, Melott, O'Brien, Pelliccioni, Rohde, Simonsen, Usoskin   +29 more
core   +1 more source

Clinicopathological and targeted exome gene features of a patient with metastatic acinic cell carcinoma of the parotid gland harboring an ARID2 nonsense mutation and CDKN2A/B deletion [PDF]

, 2015
We describe the presentation, treatment, clinical outcome, and targeted genome analysis of a metastatic salivary acinic cell carcinoma (AciCC). A 71-year-old male presented with a 3 cm right tail of a parotid lesion, first detected as a nodule by the ...
Momand, Jamil, Palma-Diaz, Fernando, Shibuya, Terry Y, Warner, Wayne A, Wong, Deborah J   +4 more
core   +4 more sources