Results 61 to 70 of about 277,677 (243)

Computational Identification and Validation of Non-Synonymous SNPs in Progesterone Receptor Membrane Complex 1 Linked to Lung Cancer

International journal of experimental research and review, 2023
Numerous gene polymorphisms have been attributed to Lung cancer, but PGRMC1 (Progesterone receptor membrane component 1) is a lesser-known candidate among them.
Solaipriya Solairaja, Habeeb Shaik Mohideen, Sivaramakrishnan Venkatabalasubramanian   +2 more
semanticscholar   +1 more source

Whole-exome sequencing and bioinformatic analyses revealed differences in gene mutation profiles in papillary thyroid cancer patients with and without benign thyroid goitre background

Frontiers in Endocrinology, 2023
BackgroundPapillary thyroid cancer (PTC) is the most common thyroid malignancy. Concurrent presence of cytomorphological benign thyroid goitre (BTG) and PTC lesion is often detected. Aberrant protein profiles were previously reported in patients with and
Zing Hong Eng, Mardiaty Iryani Abdullah, Mardiaty Iryani Abdullah, Khoon Leong Ng, Azlina Abdul Aziz, Nurul Hannis Arba’ie, Nurullainy Mat Rashid, Sarni Mat Junit   +7 more
doaj   +1 more source

Modular organization of cancer signaling networks is associated with patient survivability [PDF]

Biosystems 113, 149-154 (2013), 2013
Molecular signaling networks are believed to determine cancer robustness. Although cancer patient survivability was reported to correlate with the heterogeneous connectivity of the signaling networks inspired by theoretical studies on the increase of network robustness due to the heterogeneous connectivity, other theoretical and data analytic studies ...
arxiv   +1 more source

Protein Tyrosine Phosphatase Non-Receptor 11 (PTPN11/Shp2) as a Driver Oncogene and a Novel Therapeutic Target in Non-Small Cell Lung Cancer (NSCLC)

International Journal of Molecular Sciences, 2023
PTPN11 encodes the SHP2 protein tyrosine phosphatase that activates the mitogen-activated protein kinase (MAPK) pathway upstream of KRAS and MEK. PTPN11/Shp2 somatic mutations occur frequently in Juvenile myelomonocytic leukaemia (JMML); however, the ...
Cathy E. Richards, Yasir Y. Elamin, A. Carr, K. Gately, S. Rafee, M. Cremona, E. Hanrahan, Robert Smyth, Daniel J Ryan, R. Morgan, Susan A. Kennedy, L. Hudson, J. Fay, K. O'Byrne, B. Hennessy, S. Toomey   +15 more
semanticscholar   +1 more source

A Spatial Simulation Approach to Account for Protein Structure When Identifying Non-Random Somatic Mutations [PDF]

, 2013
Background: Current research suggests that a small set of "driver" mutations are responsible for tumorigenesis while a larger body of "passenger" mutations occurs in the tumor but does not progress the disease.
Bjornson, Robert, Cheng, Yuwei, Cheung, Kei-Hoi, Modis, Yorgo, Ryslik, Gregory, Zelterman, Daniel, Zhao, Hongyu   +6 more
core   +2 more sources

COSMIC: somatic cancer genetics at high-resolution

Nucleic Acids Res., 2016
COSMIC, the Catalogue of Somatic Mutations in Cancer (http://cancer.sanger.ac.uk) is a high-resolution resource for exploring targets and trends in the genetics of human cancer.
S. Forbes, D. Beare, Harry Boutselakis, S. Bamford, Nidhi Bindal, J. Tate, C. Cole, Sari Ward, E. Dawson, Laura Ponting, R. Stefancsik, Bhavana Harsha, C. Kok, Mingming Jia, Harry C Jubb, Zbyslaw Sondka, Sam L. Thompson, Tisham De, P. Campbell   +18 more
semanticscholar   +1 more source

CDMPred: a tool for predicting cancer driver missense mutations with high-quality passenger mutations [PDF]

PeerJ
Most computational methods for predicting driver mutations have been trained using positive samples, while negative samples are typically derived from statistical methods or putative samples.
Lihua Wang, Haiyang Sun, Zhenyu Yue, Junfeng Xia, Xiaoyan Li   +4 more
doaj   +2 more sources

TNFAIP3 mutation may be associated with favorable overall survival for patients with T-cell lymphoma

Cancer Cell International, 2021
Background T-cell lymphoma (TCL) is highly aggressive and has a poor prognosis; thus, it is worth exploring biomarkers that may predict clinical outcomes and investigate their potential role in developing targeted therapies.
Cunte Chen, Zheng Chen, Ling Huang, Lingling Zhou, Lihua Zhu, Sichu Liu, Gengxin Luo, Wenyu Li, Chengwu Zeng, Yangqiu Li   +9 more
doaj   +1 more source

Target enrichment using parallel nanoliter quantitative PCR amplification [PDF]

, 2014
Background: Next generation targeted resequencing is replacing Sanger sequencing at high pace in routine genetic diagnosis. The need for well validated, high quality enrichment platforms to complement the bench-top next generation sequencing devices is ...
De Wilde, Bram, Derveaux, Stefaan, Dong, Wes, Dunne, Jude, Hellemans, Jan, Husain, Syed, Lefever, Steve, Vandesompele, Jo   +7 more
core   +2 more sources

Loss-of-function cancer-linked mutations in the EIF4G2 non-canonical translation initiation factor

Life Science Alliance, 2023
This work identifies missense mutations in the translation initiation factor EIF4G2 gene in cancer, showing loss-of-function effects on binding to interacting proteins and translational activity.
Sara Meril, Marcela Bahlsen, Miriam Eisenstein, A. Savidor, Y. Levin, S. Bialik, S. Pietrokovski, Adi Kimchi   +7 more
semanticscholar   +1 more source