Results 71 to 80 of about 194,869 (207)

Comprehensive omics‐based classification system in adult patients with B‐cell acute lymphoblastic leukemia

Molecular Oncology, EarlyView.
The COMBAT classification system, developed through multi‐omics integration, stratifies adult patients with B‐cell acute lymphoblastic leukemia(B‐ALL) into three molecular subtypes with distinct surface antigen patterns, immune landscape, methylation patterns, biological pathways and prognosis.
Yang Song, Ting Liu, Qishan Hao, Qiuyun Fang, Xiaoyuan Gong, Yan Li, Zheng Tian, Hui Wei, Min Wang, Jianxiang Wang, Tao Cheng, Yingchang Mi   +11 more
wiley   +1 more source

Mutational profiles of marker genes of cervical carcinoma in Bangladeshi patients

BMC Cancer, 2021
Background Cervical cancer is a gynecologic cancer type that develops in the cervix, accounting for 8% mortality of all female cancer patients. Infection with specific human papillomavirus (HPV) types is considered the most severe risk factor for ...
Shahana Sharmin, Fatima Tuj Zohura, Md. Sajedul Islam, Anika Shimonty, Md. Abdullah-Al-Kamran Khan, Rehana Parveen, Foujia Sharmin, Chowdhury Rafiqul Ahsan, Abul Bashar Mir Md. Khademul Islam, Mahmuda Yasmin   +9 more
doaj   +1 more source

Challenges in identifying cancer genes by analysis of exome sequencing data. [PDF]

, 2016
Massively parallel sequencing has permitted an unprecedented examination of the cancer exome, leading to predictions that all genes important to cancer will soon be identified by genetic analysis of tumours.
Bandyopadhyay, Sourav, Carter, Hannah, Friend, Stephen, Hofree, Matan, Ideker, Trey, Kreisberg, Jason F, Mischel, Paul S   +6 more
core   +1 more source

Analysis and Interpretation of the Impact of Missense Variants in Cancer

International Journal of Molecular Sciences, 2021
Large scale genome sequencing allowed the identification of a massive number of genetic variations, whose impact on human health is still unknown. In this review we analyze, by an in silico-based strategy, the impact of missense variants on cancer ...
M. Petrosino, L. Novak, A. Pasquo, R. Chiaraluce, P. Turina, E. Capriotti, V. Consalvi   +6 more
semanticscholar   +1 more source

Association of high‐dose radioactive iodine therapy with PPM1D‐mutated clonal hematopoiesis in older individuals

Molecular Oncology, EarlyView.
In thyroid cancer patients, high‐dose (≥7.4 GBq) radioactive iodine therapy (RAIT) was associated with a higher prevalence of clonal hematopoiesis (variant allele frequency >2%) in individuals aged ≥50 years (OR = 2.44). In silico analyses showed that truncating PPM1D mutations conferred a selective advantage under these conditions.
Jaeryuk Kim, Sungwoo Bae, Jaeyong Choi, Sun‐Wha Im, Bukyoung Cha, Gyeongseo Jung, Sun Wook Cho, Eul‐Ju Seo, Young Ah Lee, Jin Chul Paeng, Young Joo Park, Jong‐Il Kim   +11 more
wiley   +1 more source

Identification of differential DNA methylation alterations of ovarian cancer in peripheral whole blood based on within-sample relative methylation orderings

Epigenetics, 2022
Leukocyte cell proportion changes affect the detection of cancer-associated aberrant DNA methylation alterations in peripheral blood samples. We aimed to detect cellular DNA methylation changes in ovarian cancer (OVC) blood samples avoiding the above ...
Hongdong Li, Fengle Jiang, Yuhui Du, Na Li, Zhihong Chen, Hao Cai, You Guo, Guini Hong   +7 more
doaj   +1 more source

Unique Performance Considerations for Printable Organic Semiconductor and Perovskite Radiation Detectors: Toward Consensus on Best Practice Evaluation

Advanced Functional Materials, EarlyView.
A lack of standard approaches for testing and reporting the performance of metal halide perovskites and organic semiconductor radiation detectors has resulted in inconsistent interpretation of performance parameters, impeding progress in the field. This Perspective recommends key metrics and experimental details, which are suggested for reporting in ...
Jessie A. Posar, Matthew Large, Andrea Ciavatti, Laura Basiricò, Beatrice Fraboni, Paul J. Sellin, Attila J. Mozer, Marco Petasecca, Matthew J. Griffith   +8 more
wiley   +1 more source

Whole-exome mutational landscape of neuroendocrine carcinomas of the gallbladder

Signal Transduction and Targeted Therapy, 2021
Neuroendocrine carcinoma (NEC) of the gallbladder (GB-NEC) is a rare but extremely malignant subtype of gallbladder cancer (GBC). The genetic and molecular signatures of GB-NEC are poorly understood; thus, molecular targeting is currently unavailable. In
Fatao Liu, Yongsheng Li, Dongjian Ying, Shimei Qiu, Yong He, Maolan Li, Yun Liu, Yijian Zhang, Qin Zhu, Yunping Hu, Liguo Liu, Guoqiang Li, Weihua Pan, Wei Jin, Jiasheng Mu, Yang Cao, Yingbin Liu   +16 more
doaj   +1 more source

Atmospheric Consequences of Cosmic Ray Variability in the Extragalactic Shock Model II: Revised ionization levels and their consequences

, 2010
It has been suggested that galactic shock asymmetry induced by our galaxy's infall toward the Virgo Cluster may be a source of periodicity in cosmic ray exposure as the solar system oscillates perpendicular to the galactic plane.
Adrian L. Melott, Aguirre, Alpen, Atri, Bancroft, Binney, Björn, Blaustein, Boucher, Brian C. Thomas, Cornette, Davidson, Dimitra Atri, Djemil, Ejzak, Foukal, Gehrels, Gies, Graham W. Wilson, Harfoot, Hatch, Häder, Jagger, Juckett, Juckett, Kiesecker, Lieberman, Lockwood, Madronich, McCallum, Medvedev, Melott, Melott, Melott, Melott, Melott, Michael J. Murray, Mikhail V. Medvedev, Natarajan, Overholt, Pukkala, Rohde, Ruderman, Scherer, Shaffer, Solanki, Svensmark, Tevini, Thomas, Thomas, Thomas   +50 more
core   +1 more source

Complex-based analysis of dysregulated cellular processes in cancer [PDF]

, 2014
Background: Differential expression analysis of (individual) genes is often used to study their roles in diseases. However, diseases such as cancer are a result of the combined effect of multiple genes.
Khanna, Kum Kum, Liu, Chao, Madhamshettiwar, Piyush B., Ragan, Mark A., Simpson, Peter T., Song, Sarah, Srihari, Sriganesh   +6 more
core   +1 more source