Results 71 to 80 of about 184,107 (180)

Severity of effect considerations regarding the use of mutation as a toxicological endpoint for risk assessment: A report from the 8th International Workshop on Genotoxicity Testing (IWGT)

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Exposure levels without appreciable human health risk may be determined by dividing a point of departure on a dose–response curve (e.g., benchmark dose) by a composite adjustment factor (AF). An “effect severity” AF (ESAF) is employed in some regulatory contexts.
Barbara L. Parsons, Marc A. Beal, Kerry L. Dearfield, George R. Douglas, Min Gi, B. Bhaskar Gollapudi, Robert H. Heflich, Katsuyoshi Horibata, Michelle Kenyon, Alexandra S. Long, David P. Lovell, Anthony M. Lynch, Meagan B. Myers, Stefan Pfuhler, Alisa Vespa, Andreas Zeller, George E. Johnson, Paul A. White   +17 more
wiley   +1 more source

Adverse Outcome Pathways Applied to Space Radiation Research

Environmental and Molecular Mutagenesis, EarlyView.
ABSTRACT Long‐duration spaceflight exposes astronauts to various stressors that can alter human physiology, potentially causing immediate and long‐term health effects. These stressors can damage biomolecules, cells, tissues, and organs, leading to adverse outcomes.
Vinita Chauhan, Veronica S. Grybas, Devyn Hoopfer, Casey Higginson, Elizabeth A. Ainsbury, Omid Azimzadeh, Afshin Beheshti, Steve Blattnig, Marjan Boerma, Sylvain V. Costes, Stephen Doty, Christelle Adam‐Guillermin, Nobuyuki Hamada, Patricia Hinton, Janice L. Huff, Robert Reynolds, Ruth C. Wilkins, Scott Wood, Carole L. Yauk   +18 more
wiley   +1 more source

Low Input Whole-Exome Sequencing to Determine the Representation of the Tumor Exome in Circulating DNA of Non-Small Cell Lung Cancer Patients. [PDF]

PLoS ONE, 2016
Circulating cell-free DNA (cfDNA) released from cancerous tissues has been found to harbor tumor-associated alterations and to represent the molecular composition of the tumor.
Steffen Dietz, Uwe Schirmer, Clémentine Mercé, Nikolas von Bubnoff, Edgar Dahl, Michael Meister, Thomas Muley, Michael Thomas, Holger Sültmann   +8 more
doaj   +1 more source

Molecular analysis of the evolutionary history of endometrial and ovarian carcinoma in Lynch syndrome

International Journal of Cancer, EarlyView.
What's New? Lynch syndrome is a prevalent cause of hereditary gynecological cancers, but the timeline of molecular alterations preceding malignancy remains unclear. By studying consecutive surveillance specimens for up to 15 years before cancer diagnosis, the authors found that atypical endometrial hyperplasia was indistinguishable from endometrial and
Anni K. Kauppinen, Alisa P. Olkinuora, Jukka‐Pekka Mecklin, Päivi T. Peltomäki   +3 more
wiley   +1 more source

Effect of PTGES3 on the Prognosis and Immune Regulation in Lung Adenocarcinoma

Analytical Cellular Pathology, 2023
Background. PTGES3 is upregulated in multiple cancer types and promotes tumorigenesis and progression. However, the clinical outcome and immune regulation of PTGES3 in lung adenocarcinoma (LUAD) are not fully understood.
Wenyan Jiang, Qiong Wei, Haiqin Xie, Dandan Wu, Haiyan He, Xuedong Lv   +5 more
doaj   +1 more source

Clinical and genetic features of multiple primary tumours cohorts with a renal cell carcinoma: Implications for molecular genetic investigations

International Journal of Cancer, EarlyView.
What's New? Current knowledge of the genetic architecture underlying the development of renal cell carcinoma‐related multiple primary tumours is limited. The authors comprehensively analysed the results of exome/genome sequencing cohorts including 534 patients to better define genotype–phenotype correlations.
Huairen Zhang, Bryndis Yngvadottir, Avgi Andreou, Yasemin Cole, Emma R. Woodward, James Whitworth, Eamonn R. Maher   +6 more
wiley   +1 more source

Detecting protein variants by mass spectrometry: a comprehensive study in cancer cell-lines

Genome Medicine, 2017
Background Onco-proteogenomics aims to understand how changes in a cancer’s genome influences its proteome. One challenge in integrating these molecular data is the identification of aberrant protein products from mass-spectrometry (MS) datasets, as ...
Javier A. Alfaro, Alexandr Ignatchenko, Vladimir Ignatchenko, Ankit Sinha, Paul C. Boutros, Thomas Kislinger   +5 more
doaj   +1 more source

Polygenic risk score and prostate specific antigen predict death from prostate cancer in men with intermediate aggressive cancer

International Journal of Cancer, EarlyView.
What's New? Using 21 SNPs, two novel PRS were constructed and used to develop two new machine‐learning classifiers, one for the detection of prostate cancer and the other for the prediction of its aggressiveness and subsequent mortality. The classifier for disease detection is built using the PRS as the sole feature, whereas the one for disease ...
Leandro Rodrigues Santiago, Efthymios Ladoukakis, Dorota Scibior‐Bentkowska, Belinda Nedjai   +3 more
wiley   +1 more source

Expanding the Spectrum of Canine Diffuse Large B-Cell Lymphoma Genetic Aberrations Through Whole Genome Sequencing Analysis. [PDF]

Vet Comp Oncol
ABSTRACT Diffuse large B‐cell lymphoma (DLBCL) is one of the most prevalent haematological malignancies in both humans and dogs, characterised in both species by significant clinical heterogeneity and limited prognostic predictability. With the introduction of next‐generation sequencing (NGS) technologies in veterinary medicine over the past decade ...
Fanelli A, Mazzone E, Giannuzzi D, Marconato L, Aresu L.   +4 more
europepmc   +2 more sources

Probing the Stability of Convolution Neural Networks and Support Vector Machines With Transmission Low Wavenumber Raman Spectroscopic Data

Journal of Raman Spectroscopy, EarlyView.
No spectral dataset is perfect, but how severely will imperfection cost you? This study finds that CNNs are more robust against spectral errors than SVMs, particularly with data that exhibits day‐to‐day calibration‐type errors. However, when no artefacts are present, the SVM produces the best model.
Mitchell Chalmers, Keith C. Gordon, Brendan McCane, Sara J. Fraser‐Miller   +3 more
wiley   +1 more source