Results 81 to 90 of about 14,211 (155)

Genome-wide somatic mutation analysis of sinonasal adenocarcinoma with and without wood dust exposure

Genes and Environment
Background Sinonasal adenocarcinoma is a rare cancer, encompassing two different entities, the intestinal-type sinonasal adenocarcinoma (ITAC) and the non-intestinal-type sinonasal adenocarcinoma (non-ITAC). Occurrence of ITAC is strongly associated with
Lauri J. Sipilä, Riku Katainen, Mervi Aavikko, Janne Ravantti, Iikki Donner, Rainer Lehtonen, Ilmo Leivo, Henrik Wolff, Reetta Holmila, Kirsti Husgafvel-Pursiainen, Lauri A. Aaltonen   +10 more
doaj   +1 more source

Papillary renal cell carcinoma with high‐ABCC2 shows an immune‐evasive profile associated with favorable response to immunotherapy

The Journal of Pathology, Volume 268, Issue 2, Page 188-199, February 2026.
Abstract The use of immune checkpoint inhibitors is a promising therapeutic strategy for metastatic papillary renal cell carcinoma (PRCC); however, predictive biomarkers remain limited. PRCCs with high ABCC2 expression represent an aggressive subset frequently associated with metastasis.
Vincent Francis Castillo, Abraam Zakhary, Fabio Rotondo, Caterina Di Ciano‐Oliveira, Malek Hamdani, Emelyn Adona, Theodorus van der Kwast, Kiril Trpkov, Rola Saleeb   +8 more
wiley   +1 more source

AI and Big Data in Oncology: A Physician‐Centered Perspective on Emerging Clinical and Research Applications [PDF]

Cancer Innov
Artificial intelligence and big data platforms are transforming oncology clinical practice. This review proposes a physician‐centered framework to integrate AI tools with real‐world data, supporting more precise diagnosis, individualized treatment, and improved patient outcomes.
Liu B, Shang Q, Li J, Yao S, Ouyang M, Wang Y, Luo S, Ouyang Q.   +7 more
europepmc   +2 more sources

Sam-Sam Association Between EphA2 and SASH1: In Silico Studies of Cancer-Linked Mutations

Molecules
Recently, SASH1 has emerged as a novel protein interactor of a few Eph tyrosine kinase receptors like EphA2. These interactions involve the first N-terminal Sam (sterile alpha motif) domain of SASH1 (SASH1-Sam1) and the Sam domain of Eph receptors ...
Marian Vincenzi, Flavia Anna Mercurio, Ida Autiero, Marilisa Leone   +3 more
doaj   +1 more source

Mathematical Constraints on Cancer Mutations: Validation of Prime-Fibonacci-Square Framework Across 30 Cancer Types in the COSMIC Database

Mary MacDiarmid
openalex   +2 more sources

Predicting high confidence ctDNA somatic variants with ensemble machine learning models

Scientific Reports
Circulating tumour DNA (ctDNA) is a minimally invasive cancer biomarker that can be used to inform treatment of cancer patients. The utility of ctDNA as a cancer biomarker depends on the ability to accurately detect somatic variants associated with ...
Rugare Maruzani, Liam Brierley, Andrea Jorgensen, Anna Fowler   +3 more
doaj   +1 more source

Long non-coding RNA FAM87A is associated with overall survival and promotes cell migration and invasion in gastric cancer

Frontiers in Oncology
BackgroundThe role of long non-coding RNAs (lncRNAs) in the invasion and metastasis of gastric cancer remains largely unclear.MethodsIntegrating transcriptome data from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases ...
Xue Jiang, Xue Jiang, Xiaobin Wu, Manjiao Lu, Wenna Fan, Jing Song, Fangzhou Song   +6 more
doaj   +1 more source

Database of recurrent mutations, an unbiased web resource to browse recurrent mutations in cancers. [PDF]

iScience
Chakroborty D, Vaparanta K, Ghimire B, Paatero I, Kurppa KJ, Elenius K.   +5 more
europepmc   +1 more source

Synonymous and non-synonymous variants at splice junctions can disrupt splicing and are frequently linked to disease associated loss of function genes. [PDF]

BMC Genomics
Srinivasan S, Subramanian S, Zhou H, Hoppmann A, Metzger P, Boerries M, Ramamoorthy S.   +6 more
europepmc   +1 more source

The genetic landscape of primary malignant melanoma of the cervix using integrated bioinformatics analysis and whole-exome sequencing. [PDF]

Front Oncol
Zhou J, Xu T, Chen C, Ping Y.
europepmc   +1 more source