Results 81 to 90 of about 186,949 (193)

Uncovering the Role of DNA Repair Impairment in UVA-Induced Mutagenesis in Human Xeroderma Pigmentosum Variant Cells. [PDF]

Mol Carcinog
ABSTRACT Ultraviolet A (UVA) radiation induces DNA damage both directly, by forming cyclobutane pyrimidine dimers (CPDs), and indirectly, by generating oxidative stress. Cells rely on nucleotide excision repair (NER) and translesion synthesis (TLS) to tolerate these lesions.
Corradi C, Moreno NC, Quintero-Ruiz N, Silva Leandro GD, Teatin Latancia M, de Souza TA, Munford V, Menck CFM.   +7 more
europepmc   +2 more sources

Papillary renal cell carcinoma with high‐ABCC2 shows an immune‐evasive profile associated with favorable response to immunotherapy

The Journal of Pathology, EarlyView.
Abstract The use of immune checkpoint inhibitors is a promising therapeutic strategy for metastatic papillary renal cell carcinoma (PRCC); however, predictive biomarkers remain limited. PRCCs with high ABCC2 expression represent an aggressive subset frequently associated with metastasis.
Vincent Francis Castillo, Abraam Zakhary, Fabio Rotondo, Caterina Di Ciano‐Oliveira, Malek Hamdani, Emelyn Adona, Theodorus van der Kwast, Kiril Trpkov, Rola Saleeb   +8 more
wiley   +1 more source

Jasmonates enhance plants tolerance grown in Cd‐contaminated environments: A comprehensive overview

Annals of Applied Biology, EarlyView.
Jasmonates (JAs) enhance plant tolerance to cadmium (Cd) stress by activating antioxidant defences but may reduce Cd uptake, limiting their effectiveness for phytoremediation. This review compiles studies that evaluated the effects of JA application on plants grown in Cd‐contaminated environments. Abstract Cadmium (Cd) is a toxic heavy metal and one of
Raja Yamma Rodrigues Souza, Cristiano Soares, Daniel Baron   +2 more
wiley   +1 more source

The Competitive Mechanism Of Ezh1 And Ezh2 In Promoting Oscc

International Dental Journal
Aim or purpose: To elucidate the roles and competitive interplay of Enhancer of Zeste Homolog 1 (EZH1) and Enhancer of Zeste Homolog 2 (EZH2) in promoting oral squamous cell carcinoma (OSCC) progression. Materials and methods: Bioinformatics analysis was
Kan Li, Shanshan Tang, Hong Jiang, Guiqing Liao, Yujie Liang, Jianghai Chen, Qiuhan Zheng   +6 more
doaj   +1 more source

Comparative Analysis of a Dual DNA–RNA Panel and a DNA‐Only Panel for Sarcoma: Real‐World Data From a Nationwide Genomic Database

Cancer Science, EarlyView.
Dual DNA–RNA panel with matched tumor–normal testing may improve diagnostic accuracy and inform treatment decisions in the routine clinical management of sarcoma. ABSTRACT Next‐generation sequencing‐based comprehensive cancer genomic profiling is promising in cancer management; however, most studies rely on tumor‐only DNA panels from single ...
Eiji Nakata, Kiichiro Ninomiya, Tatsunori Osone, Daisuke Ennishi, Shuta Tomida, Tomohiro Fujiwara, Toshiyuki Kunisada, Mashu Futagawa, Akira Hirasawa, Shinichi Toyooka, Toshifumi Ozaki   +10 more
wiley   +1 more source

Trends and Outcomes of Anticoagulation for Post‐Operative Atrial Fibrillation After Coronary Artery Bypass Graft

Pacing and Clinical Electrophysiology, EarlyView.
ABSTRACT Background The benefit of oral anticoagulation (OAC) in patients with new‐onset postoperative atrial fibrillation (POAF) after coronary bypass grafting remains uncertain. The 2023 American Heart Association (AHA) and the American College of Cardiology (ACC) guidelines recommend 60 days of anticoagulation for POAF, whereas management was ...
Daniel S. Cheah, Kathryn Tsai, Krishna Prasad Kurpad, Yousra Khalid, Sanjay S. Mehta   +4 more
wiley   +1 more source

Exploring somatic mutations in cancer with the COSMIC database and analysis tools

, 2022

openalex   +1 more source

Whole Genome Sequencing Analysis of Model Organisms Elucidates the Association Between Environmental Factors and Human Cancer Development

International Journal of Molecular Sciences
Determining a novel etiology and mechanism of human cancer requires extraction of characteristic mutational signatures derived from chemical substances.
Shinya Hasegawa, Yutaka Shoji, M. Kato, Asmaa Elzawahry, M. Nagai, Min Gi, Shugo Suzuki, Hideki Wanibuchi, S. Mimaki, K. Tsuchihara, Y. Totsuka   +10 more
semanticscholar   +1 more source

Cosmovision as Cognitive Technology: The Case of Mesoamerican Medicinal Knowledge

Topics in Cognitive Science, EarlyView.
Abstract We examine the use of cognitive technologies in the acquisition and retention of botanical and medicinal knowledge. We focus on the Cruz‐Badianus codex, a 16th‐century Nahua (Aztec) herbarium which discusses the use of plants for a range of illnesses.
Johan De Smedt, Helen De Cruz
wiley   +1 more source

Women in space: A review of known physiological adaptations and health perspectives

Experimental Physiology, EarlyView.
Abstract Exposure to the spaceflight environment causes adaptations in most human physiological systems, many of which are thought to affect women differently from men. Since only 11.5% of astronauts worldwide have been female, these issues are largely understudied.
Millie Hughes‐Fulford, Danielle J. Carroll, Heather C. M. Allaway, Bonnie J. Dunbar, Aenor J. Sawyer   +4 more
wiley   +1 more source