Results 81 to 90 of about 184,107 (180)

Multi‐site research using electronic health record data: Lessons learned from a case study

Learning Health Systems, EarlyView.
Abstract Introduction Multi‐site research collaboration is necessary to increase generalizability, diversity, and innovation; however, there are complexities and challenges surrounding research processes, including regulatory oversight, data management, and data sharing activities.
Brittany Garcia, Michael Hogarth, Yu Wang, Xi Zhu, Shin‐Ping Tu   +4 more
wiley   +1 more source

Uncovering the Role of DNA Repair Impairment in UVA‐Induced Mutagenesis in Human Xeroderma Pigmentosum Variant Cells

Molecular Carcinogenesis, EarlyView.
ABSTRACT Ultraviolet A (UVA) radiation induces DNA damage both directly, by forming cyclobutane pyrimidine dimers (CPDs), and indirectly, by generating oxidative stress. Cells rely on nucleotide excision repair (NER) and translesion synthesis (TLS) to tolerate these lesions.
Camila Corradi, Natália Cestari Moreno, Nathalia Quintero‐Ruiz, Giovana da Silva Leandro, Marcela Teatin Latancia, Tiago Antonio de Souza, Veridiana Munford, Carlos Frederico Martins Menck   +7 more
wiley   +1 more source

Chromosomal instability and genomic alterations in cholangiocarcinoma from Northeastern Thailand

The Journal of Pathology, EarlyView.
Abstract Cholangiocarcinoma (CCA) is a lethal cancer of the bile duct and is a major health concern in several parts of the world, including northeastern Thailand, where CCA incidence is the highest due to the endemic liver fluke Opisthorchis viverrini.
Raksawan Deenonpoe, Molly A Guscott, Sasithorn Watcharadetwittaya, Isabel L McNeill, Daniela Moralli, Nadeem Shaikh, Sarah E McClelland   +6 more
wiley   +1 more source

Tracing metastatic spread in pediatric solid tumors using copy number and targeted deep sequencing

The Journal of Pathology, EarlyView.
Abstract The most common cause of death in pediatric cancer patients is a treatment‐resistant tumor, compounded by metastatic spread, making surgery, radiation therapy, and chemotherapy unfeasible as curative treatment options. However, the mechanisms behind metastatic spread in pediatric tumors remain largely unexplored. We conducted whole‐genome copy
Natalie Andersson, Michele Ferro, Caroline Jansson, Subhayan Chattopadhyay, Jenny Karlsson, David Gisselsson   +5 more
wiley   +1 more source

Jasmonates enhance plants tolerance grown in Cd‐contaminated environments: A comprehensive overview

Annals of Applied Biology, EarlyView.
Jasmonates (JAs) enhance plant tolerance to cadmium (Cd) stress by activating antioxidant defences but may reduce Cd uptake, limiting their effectiveness for phytoremediation. This review compiles studies that evaluated the effects of JA application on plants grown in Cd‐contaminated environments. Abstract Cadmium (Cd) is a toxic heavy metal and one of
Raja Yamma Rodrigues Souza, Cristiano Soares, Daniel Baron   +2 more
wiley   +1 more source

Allelic Imbalance and Chromothripsis Lead to Diversity in Japanese Tumor Genomes With Whole‐Genome Duplication

Cancer Science, EarlyView.
Japanese tumor genomes with whole‐genome duplication are diversified by allele imbalance and chromothripsis. These structural abnormalities are linked to a poor prognosis for cancer patients. ABSTRACT Whole‐genome analyses have revealed that large‐scale structural variations (SVs) such as whole‐genome duplication (WGD) occur early in the development of
Keiichi Hatakeyama, Takeshi Nagashima, Sumiko Ohnami, Shumpei Ohnami, Koji Maruyama, Keiichi Ohshima, Yuji Shimoda, Akane Naruoka, Hirotsugu Kenmotsu, Kenichi Urakami, Yasuto Akiyama, Ken Yamaguchi   +11 more
wiley   +1 more source

Whole Genome Sequencing Analysis of Model Organisms Elucidates the Association Between Environmental Factors and Human Cancer Development

International Journal of Molecular Sciences
Determining a novel etiology and mechanism of human cancer requires extraction of characteristic mutational signatures derived from chemical substances.
Shinya Hasegawa, Yutaka Shoji, M. Kato, Asmaa Elzawahry, M. Nagai, Min Gi, Shugo Suzuki, Hideki Wanibuchi, S. Mimaki, K. Tsuchihara, Y. Totsuka   +10 more
semanticscholar   +1 more source

Genome‐Wide Screening in Haploid Stem Cells Reveals Synthetic Lethality Targeting MLH1 and TP53 Deficient Tumours

Cell Proliferation, EarlyView.
To identify genetic events that can lead to tumour death once either MLH1 or TP53 is mutated, a genome‐wide genetic screening was performed, uncovering a list of putative hits. Synthetic lethal interactions were validated either genetically or chemically by using small molecules that inhibit these genes either in vitro and in vivo.
Rivki Cashman, Guy Haim‐Abadi, Elyad Lezmi, Hagit Philip, Jonathan Nissenbaum, Ruth Viner‐Breuer, Chen Kozulin, Tamar Golan‐Lev, Aseel Gadban, Shiri Spinner‐Potesky, Ofra Yanuka, Oded Kopper, Nissim Benvenisty   +12 more
wiley   +1 more source

Germline genetic variants were interactively associated with somatic alterations in gastric cancer

Cancer Medicine, 2018
Genome‐wide association studies have identified several germline variants in gastric cancer. Meanwhile, sequencing studies have characterized extensive somatic alterations that arise during gastric carcinogenesis.
Xu Zhang, Yuzhuo Wang, Tian Tian, Gangqiao Zhou, Guangfu Jin   +4 more
doaj   +1 more source

A somatic multiple myeloma mutation unravels a mechanism of oligomerization‐mediated product inhibition in GGPPS

The FEBS Journal, EarlyView.
Geranylgeranyl diphosphate synthase (GGPPS) plays a key role in multiple myeloma biology. Using crystallography, mass spectrometry, and fluorescence spectroscopy, this study shows that a somatic multiple myeloma cell line mutation destabilizes inter‐dimer interactions, resulting in increased GGPPS activity by facilitating product releas.
Ruba Yehia, Jasmína Mária Portašiková, Rut Mor Yosef, Benny Da'adoosh, Alan Kádek, Petr Man, Moshe Giladi, Yoni Haitin   +7 more
wiley   +1 more source