Results 61 to 70 of about 6,026,414 (311)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Cost of Living/Cost of Smoking:A Demonstration Study of Cooperative Action Learning to Understand and Address Smoking in Deprived Communities Within the Cost-of-Living Crisis [PDF]

Smoking is responsible for over 8 million deaths globally per annum. While socially disadvantaged communities are disproportionately affected, few interventions effectively reach these groups.
Innocent, Wendy, Cost of Living/Cost of Smoking Learning Partnership, Stephen, Amanda, Stephens, Amanda, Marathia, Effie, ?, ?, Cost of Living/Cost of Smoking Learning Partnership,, Littlejohn, Chris, Duffy, Sheila, D'Ambruoso, Lucia, Littlejohn, Christopher, Cowan, Eilidh, Marathia, Eftychia   +12 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Cost-utility analysis: Incremental cost-effectiveness ratio (ICER)—base case.

, 2019
Cost-utility analysis: Incremental cost-effectiveness ratio (ICER)—base case.
Frauke Becker (2836922), Denise Howel (16468), Catherine Haighton (2157001), Martin White (16466), Andrew Bryant (5704967), Terry Aspray (6194804), Luke Vale (3435356), Elaine McColl (533649), Suzanne Moffatt (16467), Sarah Lawson (6194801), Melanie Steer (6194798), Eugene M. G. Milne (2215138)   +11 more
core   +1 more source

Cost‐effectiveness of asthma clinic approach in the management of chronic asthma in Australia

Australian and New Zealand Journal of Public Health, 2013
Objectives: To compare cost‐effectiveness of an asthma clinic that would provide education, promotion of self‐monitoring of symptoms, regular review of treatment by a medical practitioner and a written asthma action plan to current practice in Australia.
Vittal Mogasale, Theo Vos
doaj   +1 more source

The Role of Marketplace Policy on Welcome Mat Effects for Children Eligible for Medicaid or the Children’s Health Insurance Program

Inquiry: The Journal of Health Care Organization, Provision, and Financing, 2020
The Affordable Care Act (ACA) required coordination between Marketplaces, Medicaid, and the Children’s Health Insurance Program (CHIP) in an effort to streamline application processes and improve enrollment.
Julie L. Hudson PhD, Asako S. Moriya PhD
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Coronary revascularization (Examples from the world and Turkey)

Türk Kardiyoloji Derneği Arşivi, 2014
Objectives: In this article, our aims were to analyze and assess the data related to coronary revascularization rates, particularly in recent years.
Yücel Balbay, Selim Bener, Taner Kaygusuz, Serkan Çay, Erdoğan İlkay   +4 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source