Results 21 to 30 of about 91,068 (301)
Coumarin: An emerging antiviral agent
Heliyon, 2020 Viral infections are responsible for many illnesses, and recent outbreaks have raised public health concerns. Despite the availability of many antiviral drugs, they are often unsuccessful due to the generation of viral mutants and less effective against ...
Shruti Mishra +2 more
semanticscholar +1 more source
Coumarin – benzimidazole hybrids: A review on diverse synthetic strategies
Results in Chemistry, 2022 Benzimidazole and coumarin are highly significant pharmacophores in medicinal chemistry due to their numerous and compelling biological activities. It has been found that combining two or more pharmacophores in a single moiety can improve the efficiency ...
C.G. Arya +6 more
doaj +1 more source
Trending Topics on Coumarin and Its Derivatives in 2020
Molecules, 2021 Coumarins are naturally occurring molecules with a versatile range of activities. Their structural and physicochemical characteristics make them a privileged scaffold in medicinal chemistry and chemical biology. Many research articles and reviews compile
Aitor Carneiro +3 more
semanticscholar +1 more source
Coumarin-Induced Hepatotoxicity: A Narrative Review
Molecules, 2022 Coumarin is an effective treatment for primary lymphoedema, as well as lymphoedema related to breast cancer radiotherapy or surgery. However, its clinical use is limited in several countries due to the possible occurrence of hepatotoxicity, mainly in the
Michele Pitaro +5 more
semanticscholar +1 more source
MYB72-dependent coumarin exudation shapes root microbiome assembly to promote plant health
Proceedings of the National Academy of Sciences of the United States of America, 2018 Significance Plant roots nurture a large diversity of soil microbes via exudation of chemical compounds into the rhizosphere. In turn, beneficial root microbiota promote plant growth and immunity.
Ioannis A. Stringlis +9 more
semanticscholar +1 more source
Coumarin Derivatives Inhibit ADP-Induced Platelet Activation and Aggregation
Molecules, 2022 Coumarin was first discovered in Tonka bean and then widely in other plants. Coumarin has an anticoagulant effect, and its derivative, warfarin, is a vitamin K analogue that inhibits the synthesis of clotting factors and is more widely used in the ...
Ping-Hsun Lu +8 more
doaj +1 more source
The antitumor effects of mitochondria-targeted 6-(nicotinamide) methyl coumarin
Open Life Sciences, 2016 Cancer is the second leading cause of death worldwide. Traditional antitumor drugs exhibit severe cytotoxic and side effects. Lung cancer needs new and more effective treatment approaches. Coumarin derivatives can act on various tumor cells and show anti-
Wang Huanan, Yao Ming, Xu Wenqing
doaj +1 more source
Anti-biofilm activities of coumarin as quorum sensing inhibitor for Porphyromonas gingivalis
Journal of Oral Microbiology, 2022 Porphyromonas gingivalis is a keystone pathogen in periodontitis, a biofilm-mediated infection disease. This research aimed to investigate the effect of coumarin on P. gingivalis biofilm formation. We detected the antimicrobial effect on P.
Zhiyan He +6 more
doaj +1 more source
Anabolic metabolism of autotoxic substance coumarins in plants [PDF]
PeerJ, 2023 Background Autotoxicity is an intraspecific manifestation of allelopathy in plant species. The specialized metabolites and their derivatives that cause intraspecific allelopathic inhibition in the plant are known as autotoxic substances.
Bei Wu +5 more
doaj +2 more sources
Coumarin: A Natural, Privileged and Versatile Scaffold for Bioactive Compounds
Molecules, 2018 Many naturally occurring substances, traditionally used in popular medicines around the world, contain the coumarin moiety. Coumarin represents a privileged scaffold for medicinal chemists, because of its peculiar physicochemical features, and the ...
A. Stefanachi +4 more
semanticscholar +1 more source